Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rajasimhan, Rajagovindan"'
Autor:
Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 362-372 (2022)
Abstract Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory and cognitive function. Dysregulation of the amyloid‐β (Aβ) pathway and amyloid plaque accumulation in the brain are hallmarks of AD. Aducanumab
Externí odkaz:
https://doaj.org/article/7f7bb9c94560451a90a1143017ac5a1c
Autor:
Kumar Kandadi Muralidharan, Kenneth G. Kowalski, Xiao Tong, Samantha Budd Haeberlein, Rajasimhan Rajagovindan, Ivan Nestorov
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 50:45-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca54b16e0d9ecd18d92b8dbb2747d2c5
https://doi.org/10.1007/s10928-022-09839-3
https://doi.org/10.1007/s10928-022-09839-3
Autor:
Spyridon Papapetropoulos, Andrew Marsh, Andreas Meier, Rajasimhan Rajagovindan, Leslie Leahy, Ryan O'Mara, Zbigniew Wszolek
Publikováno v:
Thursday, April 27.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7310337e020406af2a53d553ceccf63d
https://doi.org/10.1212/wnl.0000000000203602
https://doi.org/10.1212/wnl.0000000000203602
Autor:
Spyridon Papapetropoulos, Andreas Meier, Ryan O'Mara, Andrew Marsh, Kelly Neelon, Rajasimhan Rajagovindan, Evan Thackaberry, David Stiles
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29c0e684e025d4724ea7e7c14ad7f27
https://doi.org/10.1212/wnl.0000000000203636
https://doi.org/10.1212/wnl.0000000000203636
Autor:
Rajasimhan Rajagovindan, Ryan O’Mara, Andreas Meier, James MacDougall, Elizabeth Finger, Jennifer Orthmann-Murphy, Daniel Broderick, Zbigniew Wszolek, Spyros Papapetropoulos
Publikováno v:
Tuesday, April 25.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3f70f87bf606e9ac93606f07548f29
https://doi.org/10.1212/wnl.0000000000203119
https://doi.org/10.1212/wnl.0000000000203119
Autor:
Kumar Kandadi Muralidharan, Kenneth G. Kowalski, Xiao Tong, Samantha Budd Haeberlein, Rajasimhan Rajagovindan, Ivan Nestoro
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65aef2f96f1a70b3ccb2697da61a2c85
https://doi.org/10.1007/s10928-023-09852-0
https://doi.org/10.1007/s10928-023-09852-0
Autor:
Karthikeyan Subramanian, David Utriainen, Deepa P. Ramasamy, Sean K. Sethi, Ferdinand Schweser, John Beaver, Jesper Hagemeier, Bianca Weinstock-Guttman, Rajasimhan Rajagovindan, Robert Zivadinov, Ewart Mark Haacke
Publikováno v:
Diagnostics, Vol 10, Iss 11, p 942 (2020)
We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and that quantitative susceptibility mapping (QSM) will help remove false positives seen in
Externí odkaz:
https://doaj.org/article/9a861f730cfd401da7dbb942d2f9b009
Autor:
Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov
Publikováno v:
CPT: pharmacometricssystems pharmacology. 11(3)
Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory and cognitive function. Dysregulation of the amyloid-β (Aβ) pathway and amyloid plaque accumulation in the brain are hallmarks of AD. Aducanumab is a human,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e22d53d7ce50029f5e08a50c56cd13
https://pubmed.ncbi.nlm.nih.gov/35029320
https://pubmed.ncbi.nlm.nih.gov/35029320
Autor:
Kumar Kandadi, Muralidharan, Kenneth G, Kowalski, Xiao, Tong, Samantha Budd, Haeberlein, Rajasimhan, Rajagovindan, Ivan, Nestorov
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics.
Clinical Dementia Rating-Sum of Boxes (CDR-SB) assessments from two Phase 3 studies (ENGAGE and EMERGE) of aducanumab in subjects with early Alzheimer's disease (AD) were pooled to develop an exposure-response (ER) model. A linear model in the logit-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adcecd70f80a3cb0f6805c1340b1f7e8
https://pubmed.ncbi.nlm.nih.gov/36600109
https://pubmed.ncbi.nlm.nih.gov/36600109
Autor:
Deepa P. Ramasamy, Bianca Weinstock-Guttman, Jesper Hagemeier, Karthikeyan Subramanian, Sean K. Sethi, Ewart Mark Haacke, Rajasimhan Rajagovindan, Robert Zivadinov, David Utriainen, Ferdinand Schweser, John D. Beaver
Publikováno v:
Diagnostics, Vol 10, Iss 942, p 942 (2020)
Diagnostics
Volume 10
Issue 11
Diagnostics
Volume 10
Issue 11
We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and that quantitative susceptibility mapping (QSM) will help remove false positives seen in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9e79853a60a2023be7b84ff44b65d3
https://www.mdpi.com/2075-4418/10/11/942
https://www.mdpi.com/2075-4418/10/11/942