Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rajashree Rana"'
Autor:
Rajashree Rana, Thomas A. Natoli, Puneet Khandelwal, Pavlos Pissios, Abdul Bari Muhammad, Vaja Chipashvili, Krista P. Farrington, Wen Zhou, Gang Zheng, Nikolay O. Bukanov, Alessandro Pocai, Maria Chiara Magnone
Publikováno v:
Physiological Reports, Vol 12, Iss 18, Pp n/a-n/a (2024)
Abstract Diabetic kidney disease (DKD) is the leading cause of end‐stage kidney disease. DKD is a heterogeneous disease with complex pathophysiology where early endothelial dysfunction is associated with disease progression. The Tie2 receptor and A
Externí odkaz:
https://doaj.org/article/42c002e16cb240158a278466fc3c5a88
Autor:
Rajashree Rana, Andrew M. Shearer, Elizabeth K. Fletcher, Nga Nguyen, Srijoy Guha, Daniel H. Cox, Manal Abdelmalek, Ying Wang, James D. Baleja, Lidija Covic, Athan Kuliopulos
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 99-113 (2019)
Objective: Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role in
Externí odkaz:
https://doaj.org/article/c69cc31ef2c14202b3177a40d35cc47e
Autor:
Andrew M. Shearer, Yanling Wang, Elizabeth K. Fletcher, Rajashree Rana, Emily S. Michael, Nga Nguyen, Manal F. Abdelmalek, Lidija Covic, Athan Kuliopulos
Publikováno v:
Hepatology (Baltimore, Md.). 76(6)
Insulin resistance and poor glycemic control are key drivers of the development of NAFLD and have recently been shown to be associated with fibrosis progression in NASH. However, the underlying mechanisms involving dysfunctional glucose metabolism an
Autor:
Elizabeth K. Fletcher, Athan Kuliopulos, Nga Nguyen, Srijoy Guha, Andrew Shearer, Daniel H. Cox, James D. Baleja, Ying Wang, Manal F. Abdelmalek, Lidija Covic, Rajashree Rana
Publikováno v:
Molecular Metabolism, Vol 29, Iss, Pp 99-113 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role in c
Autor:
Georgios Koukos, Andrew Shearer, Athan Kuliopulos, Susan E. Turner, Jeffrey J. Rade, Elizabeth K. Fletcher, Tianfang Huang, Rajashree Rana, Carey Kimmelstiel, Kevin P. Bliden, Lidija Covic, Paul A. Gurbel
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1368-1380
Objective— Protease-activated receptor-1 (PAR1) is classically activated by thrombin and is critical in controlling the balance of hemostasis and thrombosis. More recently, it has been shown that noncanonical activation of PAR1 by matrix metallopro
Autor:
Karyn M. Austin, Nga Nguyen, James D. Baleja, Athan Kuliopulos, Lidija Covic, Andrew Bohm, Andrew Shearer, Rajashree Rana
Publikováno v:
Journal of Biological Chemistry. 291:23188-23198
Chronic liver inflammation and fibrosis in nonalcoholic steatohepatitis can lead to cirrhosis and liver failure for which there are currently no approved treatments. Protease-activated receptor-2 (PAR2) is an emerging new target expressed on liver st
Autor:
Tiffany Corlin, Nga Nguyen, Rajashree Rana, James D. Baleja, Andrew J. Leger, Ping Zhang, Georgios Koukos, Andrew Bohm, Athan Kuliopulos, Lidija Covic
Publikováno v:
Journal of Biological Chemistry. 290:15785-15798
G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the cell. However, the inside surface of the receptors that couple to G proteins has not yet b
Autor:
Candace E. Carroll, Suresh Marada, Ju Bao, Christy R. Grace, Rajashree Rana, Cristina D. Guibao, Ho-Jin Lee, Stacey K. Ogden, Jie Zheng
Publikováno v:
Nature communications
Nature communications, vol 4, iss 1
Nature communications, vol 4, iss 1
Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway. Smo has an extracellular cysteine-rich domain (CRD), indispensable for its f