Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rajasekhar Chekkara"'
Autor:
Rajasekhar Chekkara, Naresh Kandakatla, Venkata Reddy Gorla, Sobha Rani Tenkayala, E Susithra
Publikováno v:
Journal of Saudi Chemical Society, Vol 21, Iss S1, Pp S311-S321 (2017)
Molecular modeling studies were carried out on a series of benzimidazole and imidazo[1,2-a]pyridines as Plk1 inhibitors. Based on the pharmacophore model, we obtained a five-featured hypothesis AADRR, with two hydrogen bond acceptors, one hydrogen bo
Externí odkaz:
https://doaj.org/article/c2065fe1d55f4a47939a11f8f5d9c92d
Autor:
Rajasekhar Chekkara, Mandava Venkata Basaveswara Rao, E. Susithra, Sobha Rani Tenkayala, Venkata Reddy Gorla, Reddymasu Sireesha
Publikováno v:
Chemical Data Collections. 29:100513
A series of 2-Aminopyrimidine linked 7-Azaindzole derivatives were designed, synthesized and evaluated for their anticancer activity against MCF-7, A549 and MDA-MB-231 human cancer cell lines by MTT assay method. The compound 11g showed potent antica
Publikováno v:
Asian Journal of Chemistry. 27:4615-4619
Publikováno v:
Oriental Journal of Chemistry. 30:1083-1098
Tubulin is attractive target for anticancer drug design and their inhibitors are useful in treatment of various cancers. Pharmacophore and Atom based QSAR studies were carried out for series of Chalcone derivatives. Pharmacophore model was developed
Publikováno v:
Frontiers in Biology. 9:410-421
Niemann-Pick disease type C1 (NPC1), caused by mutations of NPC1 gene, is an inherited lysosomal lipid storage disorder. Loss of functional NPC1 causes the accumulation of free cholesterol (FC) in endocytic organelles that comprised the characteristi
Publikováno v:
Combinatorial chemistryhigh throughput screening. 17(10)
Polo-like kinase 1 (Plk1) is a decisive enzyme with its multifunctional activity in cell cycle progression especially mitosis. The over expression of Plk1 in broad spectrum of cancer types turns into a promising therapeutic target against cancer. In
Autor:
Rajasekhar Chekkara, Sobha Rani Tenkayala, Venkata Reddy Gorla, Naresh Kandakatla, E Susithra
Publikováno v:
Journal of Saudi Chemical Society. :S311-S321
Molecular modeling studies were carried out on a series of benzimidazole and imidazo[1,2-a]pyridines as Plk1 inhibitors. Based on the pharmacophore model, we obtained a five-featured hypothesis AADRR, with two hydrogen bond acceptors, one hydrogen bo