Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Rajasekar reddy Annapureddy"'
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Silver‐Catalyzed Enantioselective Sulfimidation Mediated by Hydrogen Bonding Interactions
Autor: Stefan M. Huber, Rajasekar Reddy Annapureddy, Christian Merten, Tino P. Golub, Finn Burg, Thorsten Bach, Johannes Gramüller
Publikováno v: Angewandte Chemie (International Ed. in English)
An enantioselective sulfimidation of 3‐thiosubstituted 2‐quinolones and 2‐pyridones was achieved with a stoichiometric nitrene source (PhI=NNs) and a silver‐based catalyst system. Key to the success of the reaction is the use of a chiral phen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a1f17038f4785cc9c71f45f2a29afd
https://doi.org/10.1002/ange.202016561
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3
Novel small-molecule MRGPRX2 antagonists inhibit the murine model of allergic reactions
Autor: Mukesh Kumar, Karthi Duraisamy, Rajasekar Reddy Annapureddy, Chi Bun Chan, Billy K.C. Chow
Publikováno v: The Journal of allergy and clinical immunology.
Activation of Mas-related G protein-coupled receptor X2 (MRGPRX2) is a crucial non-IgE pathway for mast cell activation associated with allergic reactions and inflammation. Only a few peptides and small compounds targeting MRGPRX2 have been reported,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d97e559ea7bd3bbc7e1e27b3abc88ac
https://pubmed.ncbi.nlm.nih.gov/36581009
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5
A Chiral Phenanthroline Ligand with a Hydrogen-Bonding Site: Application to the Enantioselective Amination of Methylene Groups
Autor: Thorsten Bach, Christian Jandl, Rajasekar Reddy Annapureddy
Publikováno v: Journal of the American Chemical Society. 142:7374-7378
A silver-catalyzed amination is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones. The C-H amination reaction proceeded with high site- and enantioselectivity (14 examples, 83-97% ee). The key to its success is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cba42d42cbfd45e3ed4c9c68cd791a6
https://doi.org/10.1021/jacs.0c02803
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6
Continuous Flow Preparation of Benzylic Sodium Organometallics
Autor: Johannes H. Harenberg, Rajasekar Reddy Annapureddy, Konstantin Karaghiosoff, Paul Knochel
Publikováno v: Angewandte Chemie (International ed. in English). 61(30)
We report a lateral sodiation of alkyl(hetero)arenes using on-demand generated hexane-soluble (2-ethylhexyl)sodium (1) in the presence of TMEDA. (2-Ethylhexyl)sodium (1) is prepared via a sodium packed-bed reactor and used for metalations at ambient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5003dc201248eba4242ba22f76652466
https://pubmed.ncbi.nlm.nih.gov/35416397
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8
Discovery of small-molecule modulators of the secretin receptor: Purmorphamine as novel anti-hypertensive agent
Autor: Kailash Singh, Shaik Abdullah Nawabjan, Li Zhang, Hani El-Nezami, Rajasekar reddy Annapureddy, Billy KC. Chow
Publikováno v: European Journal of Medicinal Chemistry. 242:114642
The Secretin/Secretin receptor (SCTR) axis is well-known for its important role in water/salt homeostasis and blood pressure control. Recent studies revealed that absence of Secretin could lead to hypertension in animals and the administration of ext
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0a40f946c0aba215dbb63d1070ce8b
https://doi.org/10.1016/j.ejmech.2022.114642
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