Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Rajarshi Choudhury"'
2
Akademický článek
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.
Autor: Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
Publikováno v: PLoS Biology, Vol 18, Iss 12, p e3000975 (2020)
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of kno
Externí odkaz: https://doaj.org/article/5996078700384ca5bbd42dde1d166f90
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3
Akademický článek
The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery
Autor: Rajarshi Choudhury, Thomas Bonacci, Xianxi Wang, Andrew Truong, Anthony Arceci, Yanqiong Zhang, Christine A. Mills, Jennifer L. Kernan, Pengda Liu, Michael J. Emanuele
Publikováno v: Cell Reports, Vol 20, Iss 13, Pp 3212-3222 (2017)
The oncogenic AKT kinase is a key regulator of apoptosis, cell growth, and cell-cycle progression. Despite its important role in proliferation, it remains largely unknown how AKT is mechanistically linked to the cell cycle. We show here that cyclin F
Externí odkaz: https://doaj.org/article/fd5cf8abb3c04ee2b1ad1f41c93aed64
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4
Akademický článek
APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
Autor: Rajarshi Choudhury, Thomas Bonacci, Anthony Arceci, Debojyoti Lahiri, Christine A. Mills, Jennifer L. Kernan, Timothy B. Branigan, James A. DeCaprio, Daniel J. Burke, Michael J. Emanuele
Publikováno v: Cell Reports, Vol 16, Iss 12, Pp 3359-3372 (2016)
The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor Cdh1 and APC/CCdh1 plays an important role in restricting S-phase entry an
Externí odkaz: https://doaj.org/article/3fc26f609f7b4e259bca21c4e17e3a52
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5
Akademický článek
Mixed disulfide formation at Cys141 leads to apparent unidirectional attenuation of Aspergillus niger NADP-glutamate dehydrogenase activity.
Autor: Adhish S Walvekar, Rajarshi Choudhury, Narayan S Punekar
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101662 (2014)
NADP-Glutamate dehydrogenase from Aspergillus niger (AnGDH) exhibits sigmoid 2-oxoglutarate saturation. Incubation with 2-hydroxyethyl disulfide (2-HED, the disulfide of 2-mercaptoethanol) resulted in preferential attenuation of AnGDH reductive amina
Externí odkaz: https://doaj.org/article/abcc42949bbf43c09d41b87cb9ff1d94
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6
Abstract 6175: CDK8 inhibition potentiates the efficacy of niraparib in homologous recombination proficient cancer cell lines
Autor: Karen A. Simon-Crevatis, Shailesh R. Metkar, Justin T. Hardcastle, Keith Jansson, Usman Shabon, Rajarshi Choudhury, Euan A. Stronach, Kevin G. Coleman, Asli Muvaffak
Publikováno v: Cancer Research. 83:6175-6175
While cyclin dependent kinases (CDKs) were originally implicated in cell cycle regulation, several CDKs including CDK7, CDK8, and CDK9 play critical roles in transcription through regulation of RNA polymerase II (Pol II) activity. In addition to expe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e5a84d1ec42e305a931c904608fbcac
https://doi.org/10.1158/1538-7445.am2023-6175
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9
The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery
Autor: Michael J. Emanuele, Anthony Arceci, Yanqiong Zhang, Xianxi Wang, Rajarshi Choudhury, Thomas Bonacci, Andrew S. Truong, Jennifer L. Kernan, Christine A. Mills, Pengda Liu
Publikováno v: Cell Reports, Vol 20, Iss 13, Pp 3212-3222 (2017)
The oncogenic AKT kinase is a key regulator of apoptosis, cell growth, and cell-cycle progression. Despite its important role in proliferation, it remains largely unknown how AKT is mechanistically linked to the cell cycle. We show here that cyclin F
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0bb8f2aeee069120ee7879c20aeba1
https://doi.org/10.1016/j.celrep.2017.08.099
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10
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
Autor: Matthew P. Walker, Justin M. Wolter, Michael B. Major, Michael J. Emanuele, Mark J. Zylka, Jason J. Yi, Smita R. Paranjape, Rajarshi Choudhury, Giulia Fragola
Publikováno v: Journal of Biological Chemistry. 292:12503-12515
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3AT485A) that disrupts phosphorylation control of UBE3A activity. Thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859717dd2ceacf9de70bc065153abe59
https://doi.org/10.1074/jbc.m117.788448
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