Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rajaratnam Premraj"'
Autor:
Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, Hanna E. Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R. Betley, Andrew P. G. Beevers, Richard A. G. Smith, Jason A. Roberts, David L. Paterson, Matthew A. Cooper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in viv
Externí odkaz:
https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490
Akademický článek
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Targeting Bacterial Cell Wall Peptidoglycan Synthesis by Inhibition of Glycosyltransferase Activity.
Autor:
Mesleh, Michael F.1, Rajaratnam, Premraj2, Conrad, Mary1, Chandrasekaran, Vasu1, Liu, Christopher M.1, Pandya, Bhaumik A.1, Hwang, You Seok1, Rye, Peter T.3, Muldoon, Craig2, Becker, Bernd2, Zuegg, Johannes2, Meutermans, Wim2, Moy, Terence I.1
Publikováno v:
Chemical Biology & Drug Design. Feb2016, Vol. 87 Issue 2, p190-199. 10p.
Autor:
Hanna E. Sidjabat, David Edwards, Andrew P. G. Beevers, Ruby Pelingon, Zyta M. Ziora, Karl A. Hansford, Fredrik Lindahl, Noor Huda Daud, Sefetogi Ramaologa, Tanya A. Bradford, Jason A. Roberts, Mark E. Cooper, Angela M. Kavanagh, June C. Lee, Yujing Gong, David L. Paterson, Soumya Ramu, Maite Amado, Wanida Phetsang, Tomislav Karoli, Johannes Zuegg, Alberto B. Silva, Johnny X. Huang, Alysha G. Elliott, Mark S. Butler, Richard A. G. Smith, Rajaratnam Premraj, Craig Muldoon, Mark A. T. Blaskovich, Mu Cheng, Johan E. Deecke, Jason Betley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
The public health threat posed by a looming ‘post-antibiotic’ era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature’s control of biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7366661a67b35b8ed35840cfd588645
https://doi.org/10.1038/s41467-017-02123-w
https://doi.org/10.1038/s41467-017-02123-w
Akademický článek
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Autor:
Giang Le Thanh, Tony Rossetti, Rajaratnam Premraj, Craig Muldoon, Maretta Mann, Matthias Grathwohl, Michael West, Jennifer Waanders, Ligong Liu, Norbert Wimmer, Frank Vari, Giovanni Abbenante, Sébastien Blanc, Johannes Zuegg, Karl Schafer, Graeme Fraser, Geraldine Verquin, Annika Yau, Judy Halliday, Bernd Becker, Glenn Condie, Ann Lam, Senka Henderson, Gerald Tometzki, Andrew G. Pearson, Tracie Elizabeth Ramsdale, Christopher T. Clark, Wim Meutermans
Publikováno v:
Journal of Medicinal Chemistry. 53:5576-5586
Success in discovering bioactive peptide mimetics is often limited by the difficulties in correctly transposing known binding elements of the active peptide onto a small and metabolically more stable scaffold while maintaining bioactivity. Here we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2bdfa9a1b7acf04b17ce5bd3c508f8
https://doi.org/10.1021/jm1002777
https://doi.org/10.1021/jm1002777
Publikováno v:
Scopus-Elsevier
A formal total synthesis of the polyketide herboxidiene (1) has been achieved by Horner-Wittig coupling of the side-chain fragment 12-epi-(2) with the tetrahydropyran-2-acetic acid derivative (3) followed by desilylation of the resulting triene (19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c8c2c0fdf838d9cd162780d5533bf6
https://doi.org/10.1351/pac200072091631
https://doi.org/10.1351/pac200072091631
Publikováno v:
Tetrahedron Letters. 49:4854-4856
A rapid synthetic access to ACL 21269 was established in 12 steps starting from thiogylcoside 9 utilizing synthons 8 and 6 to introduce the pharmacophores at positions 1 and 2. The functional groups decorating the glucosamine scaffold were introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80fbd9880c5a14c9317eacc3073b2b7
https://doi.org/10.1016/j.tetlet.2008.06.009
https://doi.org/10.1016/j.tetlet.2008.06.009
Publikováno v:
ChemInform. 44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d77397e09a24b35527c62283640304af
https://doi.org/10.1002/chin.201315197
https://doi.org/10.1002/chin.201315197