Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Rajappa Vaidyanathan"'
Autor:
Vijayagopal Gopalsamuthiram, Dang Binh Ho, Cheryl L. Peck, Vasudevan Natarajan, Toolika Agrawal, Justina M. Burns, John Bachert, Daniel W. Cook, Rodger W. Stringham, Ryan Nelson, Saeed Ahmad, B. Frank Gupton, David R. Snead, D. Tyler McQuade, Rajappa Vaidyanathan, Kai Donsbach, Joshua D. Sieber
Publikováno v:
ACS Omega, Vol 7, Iss 8, Pp 7223-7228 (2022)
Externí odkaz:
https://doaj.org/article/5891606ae57846d2920a0e4a94cd083d
Autor:
Souvik Rakshit, Shunmugaraj Sathasivam, Raghurami Reddy, Saladi V. Rao, Vijaykumar Shekarappa, Moorthy Kandasamy, Mohamed Jaleel, Saravanan Murugan, Anuradha Bhat, Tamilarasan Subramani, Thirumalai Lakshminarasimhan, Aravind Gangu, Steven R. Wisniewski, Nathaniel Kopp, Ian Hale, Jason M. Stevens, Victor W. Rosso, Martin D. Eastgate, Rajappa Vaidyanathan
Publikováno v:
Organic Process Research & Development. 27:707-722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e26ec4f546571fe262dc12c4d2e2454f
https://doi.org/10.1021/acs.oprd.3c00007
https://doi.org/10.1021/acs.oprd.3c00007
Autor:
Arun Vinodini, Saravanan Murugan, William P. Gallagher, Sankar Kuppusamy, Rajappa Vaidyanathan, Martin D. Eastgate, Kishore Ghanta, Sivasankar Bondigela, Aravind S. Gangu, Abhishek Shrikant, Shunmugaraj Sathasivam, Srinivas Kalidindi, Vijaykumar Shekarappa, Francisco González-Bobes, Moorthy Kandasamy, Nathaniel Kopp, Ravikumar Ramachandran
Publikováno v:
Organic Process Research & Development. 25:1556-1572
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d21860e3ebf0d8dd4438293818df38f
https://doi.org/10.1021/acs.oprd.1c00125
https://doi.org/10.1021/acs.oprd.1c00125
Autor:
John R. Coombs, Francisco González-Bobes, Boguslaw Mudryk, Arun Vinodini, Sankar Kuppusamy, Candice L. Joe, Senthil Palani, Muthukrishnan Ponnusamy, Vedhachalam Nagappan, Rajappa Vaidyanathan, William P. Gallagher, Aravind S. Gangu, Martin D. Eastgate, Sanjeewa Rupasinghe, Alla Venu, Nathaniel Kopp, Srinivas Kalidindi, Shankar Tendulkar
Publikováno v:
Organic Process Research & Development. 25:1547-1555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5d45a55c301e242d68690ce145b08c
https://doi.org/10.1021/acs.oprd.1c00124
https://doi.org/10.1021/acs.oprd.1c00124
Autor:
Manjunath Gujjar, Subha Mukherjee, Souvik Rakshit, Jamison Christopher Robert, Matthew W. Haley, Chris Sfouggatakis, Matthew J. Goldfogel, Rajappa Vaidyanathan, Scott A. Savage, Jayaraj Mohan
Publikováno v:
Organic Process Research & Development. 26:624-634
The development and implementation of two process syntheses to provide BMS-986224, an agonist of the APJ receptor, are reported. The first-generation synthesis of BMS-986224 relied on a key enamine...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e782f36b4ae63b9def61dec67ea0348
https://doi.org/10.1021/acs.oprd.1c00088
https://doi.org/10.1021/acs.oprd.1c00088
Autor:
Michael A. Schmidt, Chunshan Xie, Naidu S. Chowdari, Ankita G. Niyogi, David R. Langley, Heng Cheng, Gregory D. Vite, Sivakrishna Guturi, Rajappa Vaidyanathan, Sanjeev Gangwar, Ivar M. McDonald, Kishorekumar Kanagavel, Yichen Tan, Prasanna Sivaprakasam, Souvik Rakshit, Chin Pan, Umamaheswararao Kanusu, Martin D. Eastgate, Madhura Deshpande, Somprabha Sidhar, Bin Zheng, Christiana I. Iwuagwu, Michael R. Luzung, Ganapathy Sarma, Kevin M. Peese, Thirumalai Lakshminarasimhan, Patrick G. Holder, Pina M. Cardarelli, Patricia Cho, Srikanth Kotapati, Chetana Rao
Publikováno v:
ACS Med Chem Lett
[Image: see text] A new series with the tetrahydroisoquinoline-fused benzodiazepine (TBD) ring system combined with the surrogates of (1-methyl-1H-pyrrol-3-yl)benzene (“MPB”) payloads were designed and executed for conjugation with a monoclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebc8e44bdde09da681c8a7885776a0f
https://doi.org/10.1021/acsmedchemlett.0c00578
https://doi.org/10.1021/acsmedchemlett.0c00578
Autor:
David K. Leahy, Martin D. Eastgate, Arvind Mathur, Richard Rampulla, Varadharajan Subramanian, Upender Velaparthi, Sathishkumar Chandrasekaran, Karthikeyan Chinnakalai, Arun Kumar Gupta, Antony Savarimuthu, Thirumalai Lakshminarasimhan, Souvik Rakshit, Indasi Gopikumar, Jayakumar Sankara Warrier, Chetan Padmakar Darne, Robert M. Borzilleri, Rajappa Vaidyanathan, Anuradha Gupta, Ananta Karmakar, Vignesh Radhakrishnan, Muthalagu Vetrichelvan, Dyamanna Doddalingappa, Senthil Palani
Publikováno v:
Organic Process Research & Development. 24:1310-1320
A scalable route to the small molecule TGFβR1 inhibitor BMS-986260 (1) was developed. This alternative approach circumvented the purification of intermediates by column chromatography and provided ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1479cf30ab1db39b487237c60ba0c40
https://doi.org/10.1021/acs.oprd.0c00232
https://doi.org/10.1021/acs.oprd.0c00232
Autor:
Debottam Dasgupta, Siva Sankar Bondigela, Arun Vinodini, Srinivas Kalidindi, Selin Aytar, Rajappa Vaidyanathan, Satish Korapati, Francisco González-Bobes, Prantik Maity, Aravind S. Gangu, Alla Venu, William P. Gallagher, Sri Krishna Nimmagadda, Noormohamed Abdul Malik
Publikováno v:
Organic Process Research & Development. 24:1141-1148
We describe the development and scale-up of a nickel-catalyzed reductive cross-electrophile coupling reaction between a substituted 2-chloropyridine and ethyl 3-chloropropanoate using manganese dus...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca6ee2e61a65e8ccbb306ffbca2dbfc
https://doi.org/10.1021/acs.oprd.0c00134
https://doi.org/10.1021/acs.oprd.0c00134
Autor:
Sundaramurthy Rangaswamy, Kathryn Camacho, Rajappa Vaidyanathan, Siva Krishna Guturi, Martin D. Eastgate, Durgarao Bandaru, Rajaram Ayothiraman, Kishorekumar Kanagavel, Cuniere Nicolas, Serge Zaretsky, Mohamed Jaleel, Thirumalai Lakshminarasimhan, Aravind S. Gangu
Publikováno v:
Organic Process Research & Development. 24:207-215
Two approaches to a 1-aryl-4-trifluoromethyltriazole are described. Initially, a late-stage trifluoromethylation of the corresponding 1-aryl-4-iodotriazole using methyl fluorosulfonyldifluoroacetat...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::746dc3518850e9887c08700e4cffb679
https://doi.org/10.1021/acs.oprd.9b00492
https://doi.org/10.1021/acs.oprd.9b00492
Autor:
Prantik Maity, Rajappa Vaidyanathan
Publikováno v:
Practical Synthetic Organic Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d23328bdd3a476d364427d424e26965
https://doi.org/10.1002/9781119448914.ch2
https://doi.org/10.1002/9781119448914.ch2