Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Rajan M. Thomas"'
Autor:
Matthew C Pahl, Prabhat Sharma, Rajan M Thomas, Zachary Thompson, Zachary Mount, James A Pippin, Peter A Morawski, Peng Sun, Chun Su, Daniel Campbell, Struan FA Grant, Andrew D Wells
Publikováno v:
eLife, Vol 13 (2024)
Genome-wide association studies (GWAS) have identified hundreds of genetic signals associated with autoimmune disease. The majority of these signals are located in non-coding regions and likely impact cis-regulatory elements (cRE). Because cRE functi
Externí odkaz:
https://doaj.org/article/48b8e3b4f93d4805a83e4df3a71693d2
Autor:
Rajan M Thomas, Matthew C Pahl, Liqing Wang, Struan FA Grant, Wayne W Hancock, Andrew D Wells
Publikováno v:
eLife, Vol 12 (2024)
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To det
Externí odkaz:
https://doaj.org/article/ba76a93665e24702a7a850571913d233
Autor:
Matthew C. Pahl, Carole Le Coz, Chun Su, Prabhat Sharma, Rajan M. Thomas, James A. Pippin, Emylette Cruz Cabrera, Matthew E. Johnson, Michelle E. Leonard, Sumei Lu, Alessandra Chesi, Kathleen E. Sullivan, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background SARS-CoV-2 infection results in a broad spectrum of COVID-19 disease, from mild or no symptoms to hospitalization and death. COVID-19 disease severity has been associated with some pre-existing conditions and the magnitude of the
Externí odkaz:
https://doaj.org/article/8df9b6167b7e4c4c861156596c1735c6
Autor:
Chun Su, Matthew E. Johnson, Annabel Torres, Rajan M. Thomas, Elisabetta Manduchi, Prabhat Sharma, Parul Mehra, Carole Le Coz, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, James Pippin, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the
Externí odkaz:
https://doaj.org/article/e8bc69a5fa22479099c81e256d349a2f
Autor:
Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Tregcell IL-4 production and metab
Externí odkaz:
https://doaj.org/article/89da5cb9551e485e8433cc421115f741
Autor:
Rajan M. Thomas, Matthew C. Pahl, Liqing Wang, Struan F. A. Grant, Wayne W. Hancock, Andrew D. Wells
Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios and Eos have defined roles in regulatory T cells (Treg), a role for Ikaros has not been established. To det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa238fb2735fc4eb4edfe5d0d15fdbee
https://doi.org/10.1101/2023.05.23.541951
https://doi.org/10.1101/2023.05.23.541951
Autor:
James A. Bibb, Wei Li, Rajan M. Thomas, Ayanabha Chakraborti, Florian Plattner, Susan S. Taylor, Tan C, Lucas Pozzo-Miller, Adán Hernández, David R. Benavides
Publikováno v:
Journal of Biological Chemistry. 298:102245
Cortical glutamate and midbrain dopamine neurotransmission converge to mediate striatum-dependent behaviors, while maladaptations in striatal circuitry contribute to mental disorders. However, the crosstalk between glutamate and dopamine signaling ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32172cebeb12302c858304cbd47cc959
https://doi.org/10.1016/j.jbc.2022.102245
https://doi.org/10.1016/j.jbc.2022.102245
Autor:
Rajan M. Thomas, Michael A. Wise, Victor Ye. Zagorsky, William B. Simmons, Peter M. Ihlen, Ana Margarida R. Neiva, Encarnación Roda-Robles, Hartmut Beurlen, Axel H. E. Müller
Publikováno v:
Canadian Mineralogist
This study represents the precursor and complementary study for the new classification of granitic pegmatites by Wise et al. (this issue) and provides a detailed analysis of existing classifications of granitic pegmatites in terms of applied classifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cdf580b5fb31085cfa4720bf13e2eb
https://doi.org/10.3749/canmin.1700088
https://doi.org/10.3749/canmin.1700088
Autor:
Michelle E. Leonard, Carole Le Coz, Annabel Torres, Struan F.A. Grant, Rajan M. Thomas, Chun Su, Kenyaita M. Hodge, Elisabetta Manduchi, Neil Romberg, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Sumei Lu, Parul Mehra, Prabhat K. Sharma, James A. Pippin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown. We generated h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20daf8f18d9fe7569e1dc0a99fb61a81
https://doi.org/10.1038/s41467-020-17089-5
https://doi.org/10.1038/s41467-020-17089-5
Autor:
Annabel Torres, Rajan M. Thomas, Matthew E. Johnson, Neil Romberg, Kenyaita M. Hodge, Michelle E. Leonard, Carole Le Coz, Struan F.A. Grant, Andrew D. Wells, Alessandra Chesi, James A. Pippin, Prabhat K. Sharma, Chun Su, Elisabetta Manduchi, Sumei Lu
Systemic lupus erythematosus (SLE) is a complex inflammatory disease mediated by autoreactive antibodies that damages multiple tissues in children and adults. Genome-wide association studies (GWAS) have statistically implicated hundreds of loci in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628e5305a6da9ee349a95198409f3f53
https://doi.org/10.1101/2019.12.20.885426
https://doi.org/10.1101/2019.12.20.885426