Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rajan, Sah"'
Autor:
Zhihui He, Yonghui Zhao, Michael J. Rau, James A. J. Fitzpatrick, Rajan Sah, Hongzhen Hu, Peng Yuan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
The PANX2 channel is involved in skin homeostasis and neuronal development, but the molecular basis of channel function remains largely unknown. Here, the authors provide detailed analysis of the structure, function, and pharmacology of human PANX2.
Externí odkaz:
https://doaj.org/article/a3925cea2fa94b43a3755583b41c6230
Publikováno v:
ASN Neuro, Vol 15 (2023)
Volume-regulated anion channels (VRACs) are a group of ubiquitously expressed outwardly-rectifying anion channels that sense increases in cell volume and act to return cells to baseline volume through an efflux of anions and organic osmolytes, includ
Externí odkaz:
https://doaj.org/article/1826b51ec1f2471e8e008f5b5ccf2a45
Autor:
Mustafa Balkaya, Preeti Dohare, Sophie Chen, Alexandra L. Schober, Antonio M. Fidaleo, Julia W. Nalwalk, Rajan Sah, Alexander A. Mongin
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106669- (2023)
Summary: The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LR
Externí odkaz:
https://doaj.org/article/dfcab3cafa1a457ea2a21fab246b7a9c
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Autor:
Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Healthy expansion of adipose tissue is critical for the maintenance of metabolic health, providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently sto
Externí odkaz:
https://doaj.org/article/14ee9bf53bc94ff0b590de2094e4a81a
Autor:
Daniel Turner, Chen Kang, Pietro Mesirca, Juan Hong, Matteo E. Mangoni, Alexey V. Glukhov, Rajan Sah
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
The understanding of the electrophysiological mechanisms that underlie mechanosensitivity of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the past century. The heart is constantly exposed to a dynamic mechanic
Externí odkaz:
https://doaj.org/article/7ab8744d7c2b453c85ae5fe7ecfac9a0
Autor:
Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William Sivitz, Brian Fink, Gourav Bhardwaj, Brian T. O’Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel Stephens, Timothy King, Laura Jackson, Andrew S. Greenberg, Frederick Anokye-Danso, Rexford S. Ahima, James Ankrum, Yumi Imai
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Perilipin 2 (PLIN2) is a lipid droplet (LD) protein in β cells that increases under nutritional stress. Downregulation of PLIN2 is often sufficient to reduce LD accumulation. To determine whether PLIN2 positively or negatively affects β cell functi
Externí odkaz:
https://doaj.org/article/dd53760c187d4c5581a1bfb6a1837b4d
Autor:
Ahmad F Alghanem, Javier Abello, Joshua M Maurer, Ashutosh Kumar, Chau My Ta, Susheel K Gunasekar, Urooj Fatima, Chen Kang, Litao Xie, Oluwaseun Adeola, Megan Riker, Macaulay Elliot-Hudson, Rachel A Minerath, Chad E Grueter, Robert F Mullins, Amber N Stratman, Rajan Sah
Publikováno v:
eLife, Vol 10 (2021)
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby sense fluid f
Externí odkaz:
https://doaj.org/article/078560485a37441a90c596b50ccc3063
Autor:
Ashutosh Kumar, Litao Xie, Chau My Ta, Antentor O Hinton, Susheel K Gunasekar, Rachel A Minerath, Karen Shen, Joshua M Maurer, Chad E Grueter, E Dale Abel, Gretchen Meyer, Rajan Sah
Publikováno v:
eLife, Vol 9 (2020)
Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show that SWELL1 (
Externí odkaz:
https://doaj.org/article/7f3ff750fcd64addb27a683c2c1e631a
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 223-228 (2019)
Obesity is becoming a global epidemic, predisposing to Type 2 diabetes, cardiovascular disease, fatty liver disease, pulmonary disease, osteoarthritis and cancer. Therefore, understanding the biology of adipocyte expansion in response to overnutritio
Externí odkaz:
https://doaj.org/article/d7bf3a33e18f46e3ac79efeb74d26a2a