Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rajalakshmi Balakrishna"'
Autor:
Lakshmi Ganapathi, Simon Van Haren, David J Dowling, Ilana Bergelson, Nikunj M Shukla, Subbalakshmi S Malladi, Rajalakshmi Balakrishna, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu, Sunil A David, Ofer Levy
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134640 (2015)
Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TL
Externí odkaz:
https://doaj.org/article/696380fd21fe44ccb21fccde2a8a3ea0
Autor:
Nikunj M Shukla, Deepak B Salunke, Rajalakshmi Balakrishna, Cole A Mutz, Subbalakshmi S Malladi, Sunil A David
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43612 (2012)
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunity and can be exploited as powerful vaccine adjuvants for eliciting both primary and anamnestic immune responses. TLR7 agonists are highly immunostimul
Externí odkaz:
https://doaj.org/article/bc1538427b5e4053a59df0b610153f5e
Autor:
Manoj Kumar, Xiaoqiang Guo, Euna Yoo, Alex C. D. Salyer, Toshiyuki Shimizu, Umeharu Ohto, Rajalakshmi Balakrishna, Diptesh Sil, Deepak B. Salunke, Subbalakshmi S. Malladi, Alec R. Hermanson, Ward H. Thompson, Sunil A. David, H. Tanji
Publikováno v:
Journal of Medicinal Chemistry
Toll-like receptor (TLR) 7 and 8 agonists are potential vaccine adjuvants, since they directly activate APCs and enhance Th1-driven immune responses. Previous SAR investigations in several scaffolds of small molecule TLR7/8 activators pointed to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff7bc8b28c5f720edcc59e8934bb93e
http://europepmc.org/articles/PMC4191598
http://europepmc.org/articles/PMC4191598
Autor:
Subbalakshmi S. Malladi, Sunil A. David, Katelyn J. Serafin, Rajalakshmi Balakrishna, Xinkun Wang, Victor W. Day, Euna Yoo, Nikunj M. Shukla, Deepak B. Salunke
Publikováno v:
Journal of Medicinal Chemistry. 55:8137-8151
In our ongoing search toward identifying novel and synthetically simpler candidate vaccine adjuvants, we hypothesized that the imidazo[1,2-a]pyrazines, readily accessible via the Groebke-Blackburn-Bienaymé multicomponent reaction, would possess suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4990a481362f3393485f99f0ed502c10
https://doi.org/10.1021/jm301066h
https://doi.org/10.1021/jm301066h
Autor:
Tyler C. Lewis, Rajalakshmi Balakrishna, Hemamali J. Warshakoon, Geetanjali Agnihotri, Breanna M. Crall, Timothy P. Day, Subbalakshmi S. Malladi, Sunil A. David
Publikováno v:
Journal of Medicinal Chemistry. 54:8148-8160
Toll-like receptor 2-agonistic lipopeptides typified by S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-R-cysteinyl-S-serine (PAM(2)CS) compounds are potential vaccine adjuvants. In continuation of previously reported structure-activity relationships on this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdda1cdd3e1e686d17dccd9375430a7f
https://doi.org/10.1021/jm201071e
https://doi.org/10.1021/jm201071e
Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide
Autor:
Thuan B. Nguyen, E. V. K. Suresh Kumar, Rajalakshmi Balakrishna, Sunil A. David, Matthew R. Kimbrell, Apurba Datta, Kelly A. Miller, Ashok Kumar Adisechan
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5694-5709
Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. The only therapeutic option aimed at limiting downstream systemic inflammatory processes by targeting lipopolysac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a5bbe9498deba6aaa8b9f8010b1873
https://doi.org/10.1016/j.bmc.2007.06.015
https://doi.org/10.1016/j.bmc.2007.06.015
Autor:
Shravan Arora, Diptesh Sil, Apurba Datta, Matthew R. Kimbrell, Shannon Short, Sunil A. David, Jens R. Cromer, Anurupa Shrestha, Benjamin G. Abbo, Thuan B. Nguyen, Kelly A. Miller, Subbalakshmi S. Malladi, Ashok Kumar Adisechan, Rajalakshmi Balakrishna
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2811-2819
Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to multiple-system organ failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65aeee5d3070b439764e6f63eff6ba0
https://doi.org/10.1128/aac.00200-07
https://doi.org/10.1128/aac.00200-07
Autor:
Umeharu Ohto, Sunil A. David, Simon D. van Haren, David J. Dowling, Toshiyuki Shimizu, Rajalakshmi Balakrishna, H. Tanji, Lakshmi Ganapathi, Ilana Bergelson, Ofer Levy, Subbalakshmi S. Malladi, Nikunj M. Shukla
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134640 (2015)
PLoS ONE
PLoS ONE
Background Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12cd5fd541fb0f58dc5d61db294eeaa
http://europepmc.org/articles/PMC4537157?pdf=render
http://europepmc.org/articles/PMC4537157?pdf=render
Autor:
Breanna M. Crall, Subbalakshmi S. Malladi, Lauren M. Fox, Alec R. Hermanson, Euna Yoo, Rajalakshmi Balakrishna, Sunil A. David
Publikováno v:
Organicbiomolecular chemistry. 11(38)
Engagement of TLR7 in plasmacytoid dendritic cells leads to the induction of IFN-α/β which plays essential functions in the control of adaptive immunity. We had previously examined structure-activity relationships (SAR) in TLR7/8-agonistic imidazoq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac988196697686037265dbadd3e877a
https://pubmed.ncbi.nlm.nih.gov/23974333
https://pubmed.ncbi.nlm.nih.gov/23974333
Autor:
Rajalakshmi Balakrishna, Alec R. Hermanson, Lauren M. Fox, Subbalakshmi S. Malladi, Diptesh Sil, Xinkun Wang, Sunil A. David, Anshuman Dixit, Hari Prasad Kokatla
Publikováno v:
Journal of medicinal chemistry. 56(17)
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0540cf30c3f85d1d102ff58e8e46af
https://pubmed.ncbi.nlm.nih.gov/23899291
https://pubmed.ncbi.nlm.nih.gov/23899291