Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria (CAN KNOW): an open-label randomized controlled trial

Autor: Grigg, MJ, William, T, Barber, BE, Rajahram, GS, Menon, J, Schimann, E, Wilkes, CS, Patel, K, Chandna, A, Price, RN, Yeo, TW, Anstey, NM

Publikováno v: Clinical Infectious Diseases. 66(2)

Plasmodium knowlesi is reported increasingly across Southeast Asia, and is the commonest cause of malaria in Malaysia. No randomized trials have assessed comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria.A randomized-controlle

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Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats.

Autor: Klim H; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK. hannah.klim@ndm.ox.ac.uk., William T; Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Gleneagles Hospital, Kota Kinabalu, Malaysia.; Clinical Research Centre, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia., Mellors J; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Brady C; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Rajahram GS; Clinical Research Centre, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia., Chua TH; Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; EduLife Berhad, Penampang, Sabah, Malaysia., Brazal Monzó H; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., John JL; Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia., da Costa K; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Medway, Kent, UK., Jeffree MS; Department of Public Health Medicine, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia., Temperton NJ; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Medway, Kent, UK., Tipton T; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Thompson CP; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK., Ahmed K; Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, University of Malaysia Sabah, Kota Kinabalu, Malaysia.; Research Center for Global and Local Infectious Disease, Oita University, Oita, Japan., Drakeley CJ; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Carroll MW; Nuffield Department of Medicine, Centre for Human Genetics and Pandemic Sciences Institute, University of Oxford, Oxford, UK., Fornace KM; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. kfornace@nus.edu.sg.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. kfornace@nus.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 17; Vol. 15 (1), pp. 8863. Date of Electronic Publication: 2024 Oct 17.

Neutrophil activation, acute lung injury and disease severity in Plasmodium knowlesi malaria.

Autor: Tan AF; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Sakam SSB; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Piera K; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia., Rajahram GS; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia.; Queen Elizabeth Hospital II, Ministry of Health Malaysia, Kota Kinabalu, Malaysia.; School of Medicine and Health Sciences, Monash University Malaysia, Kuala Lumpur, Malaysia., William T; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia., Barber BE; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Anstey NM; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Grigg MJ; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah - Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Kho S; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Aug 16; Vol. 18 (8), pp. e0012424. Date of Electronic Publication: 2024 Aug 16 (Print Publication: 2024).

Longitudinal changes in iron homeostasis in human experimental and clinical malaria.

Autor: Woolley SD; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Academic Department of Military Medicine, Royal Centre for Defence Medicine, Birmingham, United Kingdom., Grigg MJ; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Marquart L; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Public Health, University of Queensland, Brisbane, Australia., Gower JSE; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Piera K; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia., Nair AS; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Amante FM; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Rajahram GS; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia; Department of Medicine, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia., William T; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia; Subang Jaya Medical Centre, Subang Jaya, Malaysia., Frazer DM; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Chalon S; Medicines for Malaria Venture, Geneva, Switzerland., McCarthy JS; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Victorian Infectious Diseases Institute, Peter Doherty Institute, University of Melbourne, Melbourne, Australia., Anstey NM; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Barber BE; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia; Infectious Diseases Department, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address: bridget.barber@qimrberghofer.edu.au.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Jul; Vol. 105, pp. 105189. Date of Electronic Publication: 2024 Jun 07.

The Rapid Emergence of Hypervirulent Klebsiella Species and Burkholderia pseudomallei as Major Health Threats in Southeast Asia: The Urgent Need for Recognition as Neglected Tropical Diseases.

Autor: Kain MJW; Institute of Naval Medicine, Alverstoke, Hampshire PO12 2DL, UK., Reece NL; Headquarters Army Medical Services, Camberley GU15 4NP, UK., Parry CM; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 2JD, UK., Rajahram GS; Department of Medicine, Queen Elizabeth II Hospital, Kota Kinabalu 88300, Malaysia.; Infectious Diseases Society, Kota Kinabalu Sabah-Menzies School of Health Research, Clinical Research Unit, Kota Kinabalu 88994, Malaysia., Paterson DL; ADVANCE-ID Network, Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore.; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Woolley SD; Institute of Naval Medicine, Alverstoke, Hampshire PO12 2DL, UK.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.; Tropical and Infectious Diseases Unit, Liverpool University Hospitals Foundation NHS Trust, Liverpool L7 8YE, UK.

Publikováno v: Tropical medicine and infectious disease [Trop Med Infect Dis] 2024 Apr 08; Vol. 9 (4). Date of Electronic Publication: 2024 Apr 08.