Výsledky vyhledávání - "Rajagopal V Sekhar"

Akademický článek

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging

Autor: Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 12, Iss 5, p 1042 (2023)

Cognitive decline frequently occurs with increasing age, but mechanisms contributing to age-associated cognitive decline (ACD) are not well understood and solutions are lacking. Understanding and reversing mechanisms contributing to ACD are important

Externí odkaz: https://doaj.org/article/47a92a2a55f149c7ba6fe1743ed569df

Zobrazit plný text záznamu

Akademický článek

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

Autor: Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal V. Sekhar

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)

Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammat

Externí odkaz: https://doaj.org/article/c0f273d8e34c47f1be8231c38abb59db

Zobrazit plný text záznamu

Akademický článek

GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study

Autor: Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 11, Iss 1, p 154 (2022)

Patients with type 2 diabetes (T2D) are known to have mitochondrial dysfunction and increased insulin resistance (IR), but the underlying mechanisms are not well understood. We reported previously that (a) adequacy of the antioxidant glutathione (GSH

Externí odkaz: https://doaj.org/article/1b40ef204a964496a620fcecc449f362

Zobrazit plný text záznamu

Akademický článek

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation

Autor: Premranjan Kumar, Ob Osahon, David B. Vides, Nicola Hanania, Charles G. Minard, Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 11, Iss 1, p 50 (2021)

Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves that continually challenge healthcare systems globally. Therefore, there is an u

Externí odkaz: https://doaj.org/article/252b2622c0704a5f919943741438ca52

Zobrazit plný text záznamu

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

Autor: Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Publikováno v: The Journals of Gerontology: Series A. 78:75-89

Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f629d89ecb82dfad5abc97130b2867
https://doi.org/10.1093/gerona/glac135

Zobrazit plný text záznamu

Akademický článek

Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial

Autor: Premranjan Kumar, Chun Liu, James W. Suliburk, Charles G. Minard, Raja Muthupillai, Shaji Chacko, Jean W. Hsu, Farook Jahoor, Rajagopal V. Sekhar

Publikováno v: Biomedicines, Vol 8, Iss 10, p 390 (2020)

Background: Patients with HIV (PWH) develop geriatric comorbidities, including functional and cognitive decline at a younger age. However, contributing mechanisms are unclear and interventions are lacking. We hypothesized that deficiency of the antio

Externí odkaz: https://doaj.org/article/27516905e0c64d6fb9a2f67c97be8419

Zobrazit plný text záznamu

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage

Autor: Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar

Publikováno v: Nutrients; Volume 14; Issue 5; Pages: 1114

Determinants of length of life are not well understood, and therefore increasing lifespan is a challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2447b90a6dfb7a3b51a2da8dce25b8c
https://pubmed.ncbi.nlm.nih.gov/35268089

Zobrazit plný text záznamu

GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging

Autor: Rajagopal V. Sekhar

Publikováno v: The Journal of nutrition. 151(12)

Cellular increases in oxidative stress (OxS) and decline in mitochondrial function are identified as key defects in aging, but underlying mechanisms are poorly understood and interventions are lacking. Defects linked to OxS and impaired mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a03502d48eb0def9a102a3e9d220ba6
https://pubmed.ncbi.nlm.nih.gov/34587244

Zobrazit plný text záznamu

Autor: Rajagopal V. Sekhar, Farook Jahoor, Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles G. Minard

Publikováno v: Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)

Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammation, endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd0390be59ec9dda604727f05029be9
https://doi.org/10.1002/ctm2.372

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání