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Akademický článek

Advancing understanding of the role of IL-22 in myelination: insights from the Cuprizone mouse model

Autor: Imen Zamali, Ines Elbini, Raja Rekik, Nour-Elhouda Neili, Wafa Ben Hamouda, Ahlem Ben Hmid, Raoudha Doghri, Mélika Ben Ahmed

Publikováno v: Frontiers in Neurology, Vol 15 (2024)

Despite significant advancements in the field, the pathophysiology of multiple sclerosis (MS) remains partially understood, with limited therapeutic options available for this debilitating condition. The precise impact of Interleukin-22 (IL-22) in th

Externí odkaz: https://doaj.org/article/77c666b7fad94b5f93b3812a7745eba3

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Double-negative T cells are increased in HIV-infected patients under antiretroviral therapy

Autor: Fatma, Korbi, Imen, Zamali, Raja, Rekik, Ahlem, Ben Hmid, Mouldi, Hidri, Wafa, Kammoun Rebai, Zeineb, Jelili, Senda, Masmoudi, Souleiman Karim, Rahal, Azza, Ben Ayed, Mélika, Ben Ahmed

Publikováno v: Medicine. 101:e30182

Double-negative T (DNT) cells are a T-cell subset with a CD4-CD8- phenotype. They represent 1% to 5% of circulating lymphocytes, but an increase in this proportion can be found during lymphoproliferative and autoimmune diseases. This increase has als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef39d6a92e12d8b24de08ca89d6420b7
https://doi.org/10.1097/md.0000000000030182

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RORC overexpression as a sign of Th17 lymphocytes accumulation in multiple myeloma bone marrow

Autor: Melika Ben Ahmed, Raja Rekik, Saloua Ladeb, Neila Ben Romdhane, Oumayma Selmi, Imen Zamali, Ahlem Ben Hmid, Hajer Lamari, Ines Safra, Tarek Ben Othman

Publikováno v: Cytokine
Cytokine, Elsevier, 2020, 134, pp.155210. ⟨10.1016/j.cyto.2020.155210⟩

International audience; The role of the bone marrow microenvironment in supporting the proliferation and survival of the abnormal plasma cells in multiple myeloma (MM) is well established. Such microenvironment is rich of cytokines like IL-6, TGF-β,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c897d7a6c90211c54be389720425e000
https://hal-riip.archives-ouvertes.fr/pasteur-02942713

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Impaired TGF-β signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22

Autor: Imen Zamali, Monia Khanfir, Houman Mh, Mohamed-Ridha Barbouche, Skander Mrad, Soumaya Marzouki, Raja Rekik, Asma Beldi-Ferchiou, Melika Ben Ahmed, S. Hamzaoui, T. Larbi, Ons Kammoun

Publikováno v: Cytokine
Cytokine, Elsevier, 2018, 108, pp.182-189. ⟨10.1016/j.cyto.2018.04.011⟩

International audience; The mechanisms leading to the disruption of self-tolerance in systemic lupus erythematosus (SLE) remain elusive. Herein, we aimed to decipher the molecular basis of the impaired response of mononuclear cells to TGF-β1. The Sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6ae064f50621dc9718f15826637edf
https://doi.org/10.1016/j.cyto.2018.04.011

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An endogenous aryl hydrocarbon receptor ligand enhances de novo generation of regulatory T cells in humans

Autor: Nadia Belhadj Hmida, Imen Zamali, Raja Rekik, Ons Kammoun, Ahlem Ben Hmid, Melika Ben Ahmed, Mohamed-Ridha Barbouche

Publikováno v: Journal of Leukocyte Biology
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2018, ⟨10.1002/JLB.2AB0518-205RR⟩

The aromatic hydrocarbons receptor (AhR) is a ligand-dependent transcription factor that plays a role in mediating toxicity to xenobiotics. Its key role in immune regulation has been recently demonstrated. Recent data pointed to the efficacy of ITE (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed375ae88e76228eacba4973237b952e
https://hal-riip.archives-ouvertes.fr/pasteur-01946445

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Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

Autor: Ahlem Ben Hmid, Chayma Lajnef, Raja Rekik, Melika Ben Ahmed, Ines Zaraa, Imen Zamali

Publikováno v: International Journal of Dermatology
International Journal of Dermatology, Wiley-Blackwell, 2017, 56 (12), pp.1509--1512. ⟨10.1111/ijd.13761⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8274839eb6555c96d912d5f4f2cfd177
https://hal.archives-ouvertes.fr/hal-01876296

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Specific immune responses in mice following subchronic exposure to acetamiprid

Autor: Soumaya Marzouki, Melika Ben Ahmed, Jihene Bettaieb, Ines Bini Dhouib, Saloua El Fazaa, Chaouki Benabdessalem, Ammar Maroueni, Mohamed-Ridha Barbouche, Zakaria Bellasfar, Raoudha Doghri, Raja Rekik

Publikováno v: Life Sciences
Life Sciences, Elsevier, 2018, 188, pp.10-16. ⟨10.1016/j.lfs.2017.08.022⟩

Aims Acetamiprid (ACE) is an insecticide of the neonicotinoid family, the most widely used in the world. Herein, we assessed the effect of ACE on either the humoral or cellular immune responses of rodents. We also evaluated the role of curcumin in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cea064f0778b4ffb9975a1fceb9d769
https://pubmed.ncbi.nlm.nih.gov/28843496

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