Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Raja Mazumder"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The human gastrointestinal (gut) microbiome plays a critical role in maintaining host health and has been increasingly recognized as an important factor in precision medicine. High-throughput sequencing technologies have revolutionized -omics data ge
Externí odkaz:
https://doaj.org/article/a2c6972e87d84d5aa0d883cdfcd3993e
Autor:
Maria Dahlin, Stephanie S. Singleton, John A. David, Atin Basuchoudhary, Ronny Wickström, Raja Mazumder, Stefanie Prast-Nielsen
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104061- (2022)
Summary: Background: Recently, studies have suggested a role for the gut microbiota in epilepsy. Gut microbial changes during ketogenic diet (KD) treatment of drug-resistant epilepsy have been described. Inflammation is associated with certain types
Externí odkaz:
https://doaj.org/article/a1caa7fca9c247488ec9a4520ba1ee73
Autor:
Bhavna Hora, Naila Gulzar, Yue Chen, Konstantinos Karagiannis, Fangping Cai, Chang Su, Krista Smith, Vahan Simonyan, Sharaf Ali Shah, Manzoor Ahmed, Ana M. Sanchez, Mars Stone, Myron S. Cohen, Thomas N. Denny, Raja Mazumder, Feng Gao
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT High-throughput sequencing (HTS) has been widely used to characterize HIV-1 genome sequences. There are no algorithms currently that can directly determine genotype and quasispecies population using short HTS reads generated from long genome
Externí odkaz:
https://doaj.org/article/ad53339e65e5434399222e31b258226c
Autor:
Ting-Chia Chang, Santosh Goud, John Torcivia-Rodriguez, Yu Hu, Qing Pan, Robel Kahsay, Jonas Blomberg, Raja Mazumder
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0213770 (2019)
Human endogenous retroviruses (HERVs) have been investigated for potential links with human cancer. However, the distribution of somatic nucleotide variations in HERV elements has not been explored in detail. This study aims to identify HERV elements
Externí odkaz:
https://doaj.org/article/41855cbe578143a297082b317b4bb9dc
Autor:
Charles H King, Hiral Desai, Allison C Sylvetsky, Jonathan LoTempio, Shant Ayanyan, Jill Carrie, Keith A Crandall, Brian C Fochtman, Lusine Gasparyan, Naila Gulzar, Paul Howell, Najy Issa, Konstantinos Krampis, Lopa Mishra, Hiroki Morizono, Joseph R Pisegna, Shuyun Rao, Yao Ren, Vahan Simonyan, Krista Smith, Sharanjit VedBrat, Michael D Yao, Raja Mazumder
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0206484 (2019)
A comprehensive knowledge of the types and ratios of microbes that inhabit the healthy human gut is necessary before any kind of pre-clinical or clinical study can be performed that attempts to alter the microbiome to treat a condition or improve the
Externí odkaz:
https://doaj.org/article/f1404c71905a4888a51f757bd3a82748
Autor:
Gil Alterovitz, Dennis Dean, Carole Goble, Michael R Crusoe, Stian Soiland-Reyes, Amanda Bell, Anais Hayes, Anita Suresh, Anjan Purkayastha, Charles H King, Dan Taylor, Elaine Johanson, Elaine E Thompson, Eric Donaldson, Hiroki Morizono, Hsinyi Tsang, Jeet K Vora, Jeremy Goecks, Jianchao Yao, Jonas S Almeida, Jonathon Keeney, KanakaDurga Addepalli, Konstantinos Krampis, Krista M Smith, Lydia Guo, Mark Walderhaug, Marco Schito, Matthew Ezewudo, Nuria Guimera, Paul Walsh, Robel Kahsay, Srikanth Gottipati, Timothy C Rodwell, Toby Bloom, Yuching Lai, Vahan Simonyan, Raja Mazumder
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e3000099 (2018)
A personalized approach based on a patient's or pathogen's unique genomic sequence is the foundation of precision medicine. Genomic findings must be robust and reproducible, and experimental data capture should adhere to findable, accessible, interop
Externí odkaz:
https://doaj.org/article/bbd794c3af23484fb3a78d9a677097d5
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152725 (2016)
The number of published articles describing associations between mutations and diseases is increasing at a fast pace. There is a pressing need to gather such mutation-disease associations into public knowledge bases, but manual curation slows down th
Externí odkaz:
https://doaj.org/article/c1e0e9aa3bbb4d628d1e50dbe6e2326c
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99033 (2014)
Due to the size of Next-Generation Sequencing data, the computational challenge of sequence alignment has been vast. Inexact alignments can take up to 90% of total CPU time in bioinformatics pipelines. High-performance Integrated Virtual Environment
Externí odkaz:
https://doaj.org/article/e7de2d783bab47bfbb46948cd3a2722e
Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genes.
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36212 (2012)
N-linked glycosylation is one of the most frequent post-translational modifications of proteins with a profound impact on their biological function. Besides other functions, N-linked glycosylation assists in protein folding, determines protein orient
Externí odkaz:
https://doaj.org/article/da40f953626d4ed899d175b99d09eb46
Autor:
Chuming Chen, Darren A Natale, Robert D Finn, Hongzhan Huang, Jian Zhang, Cathy H Wu, Raja Mazumder
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18910 (2011)
The accelerating growth in the number of protein sequences taxes both the computational and manual resources needed to analyze them. One approach to dealing with this problem is to minimize the number of proteins subjected to such analysis in a way t
Externí odkaz:
https://doaj.org/article/91325256431f471fb895dc45c1093642