The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analysesResearch in context

Autor: Benjamin G. Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn A. Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, Jennifer S. Gregory, Richard M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, Timothy Cootes, Joyce Van Meurs, John P. Kemp, Jonathan H. Tobias

Publikováno v: EBioMedicine, Vol 95, Iss , Pp 104759- (2023)

Summary: Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJ

Externí odkaz: https://doaj.org/article/e65b32b807094d3195f523dc966a7bd4

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults

Autor: Benjamin G. Faber, Monika Frysz, April E. Hartley, Raja Ebsim, Cindy G. Boer, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Lorraine Southam, William Giles, Christine L. Le Maitre, J. Mark Wilkinson, Joyce B.J. van Meurs, Eleftheria Zeggini, Timothy Cootes, Claudia Lindner, John P. Kemp, George Davey Smith, Jonathan H. Tobias

Publikováno v: Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis & rheumatology (Hoboken, N.J.) . https://doi.org/10.1002/art.42451
Faber, B G, Frysz, M, Hartley, A E, Ebsim, R, Boer, C G, Saunders, F R, Gregory, J S, Aspden, R M, Harvey, N C, Southam, L, Giles, W, Le Maitre, C L, Wilkinson, J M, van Meurs, J B J, Zeggini, E, Cootes, T, Lindner, C, Kemp, J P, Davey Smith, G & Tobias, J H 2023, ' A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults ', Arthritis and Rheumatology, vol. 75, no. 6, pp. 900-909 . https://doi.org/10.1002/art.42451
Arthritis and Rheumatology, 75(6), 900-909. John Wiley & Sons Ltd.

Objective: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd8b0936adf27c13378ae0983ce92e5
https://doi.org/10.1002/art.42451

Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank

Autor: Fiona R. Saunders, Richard M. Aspden, Timothy F. Cootes, G Davey Smith, Claudia Lindner, B.G. Faber, Raja Ebsim, Monika Frysz, Nicholas C. Harvey, Jennifer S. Gregory, Jonathan H Tobias

Publikováno v: Faber, B G, Ebsim, R, Saunders, F R, Frysz, M, Gregory, J S, Aspden, R M, Harvey, N, Smith, G D, Cootes, T, Lindner, C & Tobias, J H 2021, ' Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank ', Osteoarthritis and Cartilage, vol. 29, no. 11, pp. 1521-1529 . https://doi.org/10.1016/j.joca.2021.08.002
Faber, B G, Frysz, M R, Davey Smith, G, Tobias, J H & al., E 2021, ' Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip : findings from a cross-sectional study in UK Biobank ', Osteoarthritis and Cartilage, vol. 29, no. 11, pp. 1521-1529 . https://doi.org/10.1016/j.joca.2021.08.002
Osteoarthritis and Cartilage

Objectives To examine whether acetabular dysplasia (AD), cam and/or pincer morphology are associated with radiographic hip osteoarthritis (rHOA) and hip pain in UK Biobank (UKB) and, if so, what distribution of osteophytes is observed.DesignParticipa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfa5ab992a47c9bde72228c251ff680
https://doi.org/10.1016/j.joca.2021.08.002

Automatic Segmentation of Hip Osteophytes in DXA Scans Using U-Nets

Autor: Raja Ebsim, Benjamin G. Faber, Fiona Saunders, Monika Frysz, Jenny Gregory, Nicholas C. Harvey, Jonathan H. Tobias, Claudia Lindner, Timothy F. Cootes

Publikováno v: Lecture Notes in Computer Science ISBN: 9783031164422

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab7a559fc420d012b2f281fc7dd8d7f9
https://doi.org/10.1007/978-3-031-16443-9_1

Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach

Autor: Timothy F. Cootes, Raja Ebsim, Claudia Lindner, George Davey Smith, Monika Frysz, Jonathan H Tobias, Fiona R. Saunders, Benjamin G. Faber

Publikováno v: Wellcome open research. 6

Introduction: Alpha angle (AA) is a widely used imaging measure of hip shape that is commonly used to define cam morphology, a bulging of the lateral aspect of the femoral head. Cam morphology has shown strong associations with hip osteoarthritis (OA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c182ece9d42d9e345fee41965198abed
https://pubmed.ncbi.nlm.nih.gov/36072553