KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis.

Autor: Sigafoos AN; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Tolosa EJ; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Carr RM; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota.; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota., Fernandez-Barrena MG; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Almada LL; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Pease DR; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Hogenson TL; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Raja Arul GL; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Mousavi F; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.; Department of Oncology, University of Western Ontario, London, Canada., Sen S; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Vera RE; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Marks DL; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Flores LF; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., LaRue-Nolan KC; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Wu C; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Bamlet WR; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota., Vrabel AM; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota., Sicotte H; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota., Schenk EL; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota., Smyrk TC; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., Zhang L; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., Rabe KG; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota., Oberg AL; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota., Zaphiropoulos PG; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Chevet E; Université de Rennes, CEDEX, Rennes, France., Graham RP; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., Hagen CE; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., di Magliano MP; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan., Elsawa SF; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota.; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire., Pin CL; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.; Department of Oncology, University of Western Ontario, London, Canada., Mao J; University of Massachusetts Medical School, Worcester, Massachusetts., McWilliams RR; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota., Fernandez-Zapico ME; Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Jul 01; Vol. 4 (7), pp. 1677-1689.

GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.

Autor: Almada LL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Barroso K; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA; INSERM U1242, 'Oncogenesis, Stress, Signaling', Université de Rennes, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France., Sen S; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Toruner M; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Sigafoos AN; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Raja Arul GL; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Pease DR; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Vera RE; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Olson RLO; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Auner HW; Imperial College London, London, UK., Pedeux R; INSERM U1242, 'Oncogenesis, Stress, Signaling', Université de Rennes, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France., Iovanna JL; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France., Chevet E; INSERM U1242, 'Oncogenesis, Stress, Signaling', Université de Rennes, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France. Electronic address: eric.chevet@inserm.fr., Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA. Electronic address: fernandezzapico.martin@mayo.edu.

Publikováno v: Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2023 Jun; Vol. 1866 (2), pp. 194924. Date of Electronic Publication: 2023 Feb 25.

PI3Kα targeting, nipping pancreatic cancer evolution in the bud.

Autor: Raja Arul GL; Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA., Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2021 Jul 07; Vol. 13 (7), pp. e14362. Date of Electronic Publication: 2021 May 31.

Exploring the interplay of natural products and long non-coding RNAs in colorectal cancer: pathogenesis, diagnosis, and overcoming drug resistance.

Autor: Elimam H; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt. Hanan.Elimam@fop.usc.edu.eg., Eldeib MG; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, 11231, Cairo, Egypt.; Department of Biochemistry, Faculty of Pharmacy, Sinai University-Kantara Branch, Ismailia, 41636, Egypt., Kizilaslan EZ; Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Alhamshry NAA; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt., Ashour AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Salman International University, Ras Sudr, South Sinai, Egypt., Elfar N; School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, 11578, Cairo, Egypt.; Egyptian Drug Authority, Ministry of Health and Population, Cairo, 11567, Egypt., Abdel-Wahab MM; Department of Biochemistry, Faculty of Pharmacy, Sinai University-Kantara Branch, Ismailia, 41636, Egypt., Zaki MB; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt., Mohammed OA; Department of Pharmacology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia., Radwan AF; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Cairo, 11829, Egypt., Abdel-Reheim MA; Department of Pharmacology, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia. m.ahmed@su.edu.sa.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62521, Egypt. m.ahmed@su.edu.sa., Moussa R; Faculty of Medicine, Helwan University, Cairo, 11795, Egypt., Doghish AS; Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo, Badr City, 11829, Cairo, Egypt.; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Nasr City, 11231, Cairo, Egypt.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Sep 17. Date of Electronic Publication: 2024 Sep 17.