Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Raj K.S. Badhan"'
Autor:
Raj K.S. Badhan, He Yu
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3507-3519
Gefitinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, is used to treat non-small-cell lung cancer (NSCLC). Lung cancer rates are high in China and are expected to increase over the next decade. CYP 2D6 inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5725618f2112ae0cfb4dd84c1fafc308
https://doi.org/10.1016/j.xphs.2021.05.008
https://doi.org/10.1016/j.xphs.2021.05.008
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:252-262
Background Sertraline is known to undergo changes in pharmacokinetics during pregnancy. CYP 2C19 has been implicated in the inter-individual variation in clinical effect associated with sertraline activity. However, knowledge of suitable dose titrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9fa165055f917bd1dd9a8bede0c255
https://doi.org/10.1002/bdd.2278
https://doi.org/10.1002/bdd.2278
Autor:
Raj K.S. Badhan, Khaled Abduljalil
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 47:319-340
Drugs can have harmful effects on the embryo or the fetus at any point during pregnancy. Not all the damaging effects of intrauterine exposure to drugs are obvious at birth, some may only manifest later in life. Thus, drugs should be prescribed in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbd325f6767a01d615f81b43664b9d7
https://doi.org/10.1007/s10928-020-09698-w
https://doi.org/10.1007/s10928-020-09698-w
Publikováno v:
Journal of liposome research. 32(2)
In recent years, the incidence of skin cancer has increased worldwide, presenting a significant burden on healthcare services. Chemotherapy intervention is often not appropriate for all patients due to localized adverse effects on skin physiology. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81b3dc2ee96b884bc517019530804cc
https://pubmed.ncbi.nlm.nih.gov/34423727
https://pubmed.ncbi.nlm.nih.gov/34423727
Publikováno v:
Drug and Alcohol Dependence. 200:168-180
Background The use of oral methadone in opioid substitution treatment (OST) for the management of opioid use disorder is established clinical practice. Confounding treatment is the increased risks of contracting Mycobacterium tuberculosis, the mainst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac3ecd3d5a43c55785be336af5f7915
https://doi.org/10.1016/j.drugalcdep.2019.03.013
https://doi.org/10.1016/j.drugalcdep.2019.03.013
Publikováno v:
Journal of pharmaceutical sciences. 109(10)
Tuberculosis (TB) is believed to affect around 10 million people worldwide. Treatment for TB includes isoniazid and rifampicin, with fixed-dose combination (FDC) recommended for improved patient compliance. Similarly, orally disintegrating tablets (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed34c49f88d95e3dbf25a08a6caa4d30
https://pubmed.ncbi.nlm.nih.gov/32710905
https://pubmed.ncbi.nlm.nih.gov/32710905
Autor:
Raj K.S. Badhan, Hannah Macfarlane
Objectives The second-generation antipsychotic quetiapine has been demonstrated to undergo gestation-related changes in pharmacokinetics. This study applied pharmacokinetic modelling principles to investigate the mechanism of these changes and to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3a12afea5408f36f8e5a3a97afc8cc
https://publications.aston.ac.uk/id/eprint/41193/1/Quetiapine_dose_optimisation.pdf
https://publications.aston.ac.uk/id/eprint/41193/1/Quetiapine_dose_optimisation.pdf
Autor:
Basma Elbakary, Raj K.S. Badhan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
The blood-brain barrier (BBB) serves to protect and regulate the CNS microenvironment. The development of an in-vitro mimic of the BBB requires recapitulating the correct phenotype of the in-vivo BBB, particularly for drug permeation studies. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05139426bb276852aaadab375a54dd57
https://doi.org/10.1038/s41598-020-60689-w
https://doi.org/10.1038/s41598-020-60689-w
Publikováno v:
The Journal of pharmacy and pharmacologyReferences. 72(8)
Objective Paroxetine has been demonstrated to undergo gestation-related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking. Methods A p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04901cc81fa764d3680779c8fb6791ad
https://pubmed.ncbi.nlm.nih.gov/32346890
https://pubmed.ncbi.nlm.nih.gov/32346890
Autor:
Raj K.S. Badhan, Zaril Zakaria
Publikováno v:
European Journal of Pharmaceutical Sciences. 119:90-101
Lumefantrine is a widely used antimalarial in children in sub-Saharan Africa and is predominantly metabolised by CYP3A4. The concomitant use of lumefantrine with the antiretroviral efavirenz, which is metabolised by CYP2B6 and is an inducer of CYP3A4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fde5324ca6f22aa2735b2091cd73a05
https://doi.org/10.1016/j.ejps.2018.04.012
https://doi.org/10.1016/j.ejps.2018.04.012