Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Raj K Kurupati"'
Autor:
Douglas V Dolfi, Kathleen D Mansfield, Raj K Kurupati, Senthil Kannan, Susan A Doyle, Hildegund C J Ertl, Kenneth E Schmader, E John Wherry
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77164 (2013)
Current yearly influenza virus vaccines induce strain-specific neutralizing antibody (NAb) responses providing protective immunity to closely matched viruses. However, these vaccines are often poorly effective in high-risk groups such as the elderly
Externí odkaz:
https://doaj.org/article/f6e91471e32d431baab54f6c858f932d
Autor:
Ramin Sedaghat Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100262- (2021)
Summary: Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key
Externí odkaz:
https://doaj.org/article/0fb65846491c44cdad749990a1c0edc9
Autor:
Ramin Sedaghat Herati, David A. Knorr, Laura A. Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A. Apostolidis, Alexander C. Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P. Staupe, Sharon A. Adamski, Senthil Kannan, Raj K. Kurupati, Hildegund C. J. Ertl, Jeffrey L. Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M. Schuchter, Ritesh R. Kotecha, Samuel A. Funt, Martin H. Voss, Robert J. Motzer, Chung-Han Lee, Dean F. Bajorin, Tara C. Mitchell, Jeffrey V. Ravetch, E. John Wherry
Publikováno v:
Nature Immunology. 23:1183-1192
Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells, including follicular helper CD4 T cells (Tfh) which are involved in germinal centre respons
Autor:
Yan Li, Hildegund C.J. Ertl, Xiangyang Zhou, Katherine A. High, Klaudia Kuranda, Zhiquan Xiang, Raj K. Kurupati, Federico Mingozzi
Publikováno v:
Molecular Therapy. 28:771-783
Transfer of genes by adeno-associated virus (AAV) vectors is benefiting patients with particular genetic defects. Challenges remain by rejection of AAV-transduced cells, which may be caused by CD8+ T lymphocytes directed to AAV capsid antigens. Reduc
Autor:
Raj K. Kurupati, Atul Pathak, Yogendra Singh, Soma Patnaik, Anita Aggarwal, K.C. Gupta, Pradeep Kumar, Suresh P. Vyas, Archana Swami
Publikováno v:
Pharmaceutical Research. 37
Cationic polymers (i.e. polyallylamine, poly-L-lysine) having primary amino groups are poor transfection agents and possess high cytotoxicity index when used without any chemical modification and usually entail specific receptor mediated endocytosis
Autor:
Susan A. Doyle, Divyansh Agarwal, Hildegund C.J. Ertl, Kenneth E. Schmader, Andrew V. Kossenkov, Raj K. Kurupati
Publikováno v:
Immunity & Ageing, Vol 15, Iss 1, Pp 1-13 (2018)
Immunity & Ageing : I & A
Immunity & Ageing : I & A
Background The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studies have demonstrated that commo
Publikováno v:
Cancer Immunology, Immunotherapy
Human immunotherapy with checkpoint blockades has achieved significant breakthroughs in recent years. In this study, a checkpoint blockade vaccine for canine melanoma was tested for safety and immunogenicity. Five healthy adult dogs received a mixtur
Autor:
Zhiquan Xiang, Steven E. Bosinger, Mark G. Lewis, Tiffany M. Styles, Malte Zopfs, Xiangyang Zhou, James M. Billingsley, Yan Li, Steven Tuyishime, Larissa H. Haut, Qin Liu, Diane G. Carnathan, Sailaja Gangahara, Hildegund C.J. Ertl, Rama Rao Amara, Raj K. Kurupati, Guido Silvestri
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 25-35 (2018)
We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)mac239 tested in HAdV-seropositive rhesus macaques (RMs) r
Autor:
Xiangfan Yin, S. Kannan, Larissa H. Haut, Louise C. Showe, Raj K. Kurupati, Andrew Kossenkoff, Qin Liu, Hildegund C.J. Ertl, Kenneth E. Schmader, Susan A. Doyle
Publikováno v:
Vaccine. 35:3700-3708
Antibody responses, B cell subset distribution in blood and the blood transcriptome were analyzed in younger and aged human subjects before and after vaccination with the inactivated influenza vaccine. In the aged, but not the younger, individuals we
Autor:
S. Kannan, Luisa Victoria Silva, Bertram Bengsch, E. J. Wherry, David H. Canaday, Andrew V. Kossenkov, A. Muselman, Kenneth E. Schmader, Cécile Alanio, Sasi K. Manne, Ramin S. Herati, Susan A. Doyle, Laura A. Vella, Raj K. Kurupati, Hildegund C.J. Ertl
Humoral immune responses are dysregulated with aging but details remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the subset that provides critical help to B cells for e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b5289a9033c67774d9ab398d2518b0
https://doi.org/10.1101/711911
https://doi.org/10.1101/711911