Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception

Autor: Aron H. Lichtman, Lamont Booker, Anu Mahadevan, Raj K. Razdan, Pattipati S. Naidu

Publikováno v: Drug and Alcohol Dependence. 105:42-47

Considerable preclinical research has demonstrated the efficacy of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of animal models of pain, but few studies have examined other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9864c2d63a934b6f3cb98ae506bc5ae
https://doi.org/10.1016/j.drugalcdep.2009.06.009

The role of fluorine substitution in the structure–activity relationships (SAR) of classical cannabinoids

Autor: Jenny L. Wiley, Anu Mahadevan, Peter J. Crocker, Raj K. Razdan, Billy R. Martin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:1504-1507

Fluorine’s high electronegativity and small size are among the special properties that contribute to its importance in medicinal chemistry.1 The effects of fluorine substitution on the biological behaviour of biologically active molecules have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2835740e26c0d63c4c25b3f5c26b2004
https://doi.org/10.1016/j.bmcl.2007.01.006

Cannabidiol displays unexpectedly high potency as an antagonist of CB1and CB2receptor agonistsin vitro

Autor: Roger G. Pertwee, Ruth A. Ross, A. M. Phillips, Raj K. Razdan, Gemma L. Baillie, Adèle Thomas

Publikováno v: British Journal of Pharmacology. 150:613-623

Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid CB1 and CB2 receptors. We have shown previously that cannabidiol can enhance electrically evoked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fb3e6cc1420abc973f78a7d5f83e1cc
https://doi.org/10.1038/sj.bjp.0707133

Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice

Autor: Billy R. Martin, Jenny L. Wiley, Raj K. Razdan

Publikováno v: Life Sciences. 80:24-35

The pharmacological profiles of the endocannabinoid anandamide and exogenous cannabinoids (e.g., Delta9-tetrahydrocannabinol) are similar, but not exactly the same. One notable difference is that anandamide's in vivo effects in mice are not blocked b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35253f87c6ba2825cf8a63b79ffe3a94
https://doi.org/10.1016/j.lfs.2006.08.017

New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis

Autor: Alessia Ligresti, David Baker, Jenny L. Wiley, Raj K. Razdan, Gareth Pryce, Maria Grazia Cascio, Cristina Visintin, Luciano De Petrocellis, Sanjitha Kulasegram, Irina Beletskaya, Bijali Saha, Billy R. Martin, Vincenzo Di Marzo, Anu Mahadevan

Publikováno v: British journal of pharmacology 147 (2006): 83–91. doi:10.1038/sj.bjp.0706418
info:cnr-pdr/source/autori:Ligresti A; Cascio MG; Pryce G; Kulasegram S; Beletskaya I; De Petrocellis L; SahaB; Mahadevan A; Visentin C; Wiley JL; Baker D; Martin BR; Razdan RK; Di Marzo V/titolo:New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis/doi:10.1038%2Fsj.bjp.0706418/rivista:British journal of pharmacology/anno:2006/pagina_da:83/pagina_a:91/intervallo_pagine:83–91/volume:147

We previously reported that the compound O-2093 is a selective inhibitor of the reuptake of the endocannabinoid anandamide (AEA). We have now re-examined the activity of O-2093 in vivo and synthesized four structural analogs (O-2247, O-2248, O-3246,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf404a14584e20d250b30ac7ce5d4738
https://doi.org/10.1038/sj.bjp.0706418