Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Raj D. Ghai"'
Autor:
S. Chen, Motilal B. Pamnani, Francis J. Haddy, Raj D. Ghai, James F. Schooley, Howard J. Bryant
Publikováno v:
Clinical and Experimental Hypertension. 22:45-62
Thiorphan, a neutral endoprotease (NEP) enzyme inhibitor, has been shown to enhance the effects of atrial natriuretic peptide (ANP) in vivo. In this study, we examined the effects of an intravenous (iv) infusion of thiorphan on cardiovascular hemodyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089949cfcd3cb49f2ead62542bf7e7bd
https://doi.org/10.1081/ceh-100100061
https://doi.org/10.1081/ceh-100100061
α-Mercaptoacyl dipeptides that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11
Autor:
Ying Qiao, Carol Berry, Kenneth Chan, Shripad S. Bhagwat, Raj D. Ghai, Cynthia A. Fink, Candido Gude, Yumi Sakane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:735-738
α-Mercaptoacyl dipeptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c94547c0193c741aeaa45b096b9807
https://doi.org/10.1016/0960-894x(95)00105-3
https://doi.org/10.1016/0960-894x(95)00105-3
Autor:
Ying Qiao, Shripad S. Bhagwat, Raj D. Ghai, Cynthia A. Fink, Kenneth Chan, Candido Gude, Yumi Sakane, Carol Berry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2673-2676
Analogs of captopril and enalapril with a thiorphan-like substituent at the 4-position of the proline ring were synthesized and found to be dual inhibitors of angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15e2bcf39f4148fba0a734e393733aa
https://doi.org/10.1016/s0960-894x(01)80694-6
https://doi.org/10.1016/s0960-894x(01)80694-6
Autor:
D. Cote, James L. Stanton, Angelo J. Trapani, Yumi Sakane, Carol Berry, Donald M. Sperbeck, Raj D. Ghai
Publikováno v:
Journal of Medicinal Chemistry. 36:3829-3833
A series of 13- and 14-membered ring lactam derivatives 9a,b, 10, 11, and 12a-c was prepared from L-cysteine. Compounds 9a,b and 12a,b were tested in vitro for inhibition of neutral endopeptidase 24.11 (NEP) and angiotensin converting enzyme (ACE) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfc486579b1196242601725b169a82e
https://doi.org/10.1021/jm00076a010
https://doi.org/10.1021/jm00076a010
Autor:
James L. Stanton, Raj D. Ghai, Carol Berry, Angelo J. Trapani, D. Cote, Yumi Sakane, Donald M. Sperbeck
Publikováno v:
ChemInform. 25
A series of 13- and 14-membered ring lactam derivatives 9a,b, 10, 11, and 12a-c was prepared from L-cysteine. Compounds 9a,b and 12a,b were tested in vitro for inhibition of neutral endopeptidase 24.11 (NEP) and angiotensin converting enzyme (ACE) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d645b086cb7a3403c4f8417375cb0fd
https://doi.org/10.1002/chin.199425166
https://doi.org/10.1002/chin.199425166
Autor:
Carol Berry, Yumi Sakane, Angelo J. Trapani, Clive G. Diefenbacher, Andrew M. Yuan, Gary Michael Ksander, Raj D. Ghai, Reynalda deJesus
Publikováno v:
Journal of medicinal chemistry. 38(10)
The synthesis of three series of dicarboxylic acid dipeptide neutral endopeptidase 24.11 (NEP) inhibitors is described. In particular, the amino butyramide 21a exhibited potent NEP inhibitory activity (IC50 = 5.0 nM) in vitro and in vivo. Blood level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfde49b64635626fda420705aa8ab574
https://pubmed.ncbi.nlm.nih.gov/7752193
https://pubmed.ncbi.nlm.nih.gov/7752193