Nucleolin Rescues TDP-43 Toxicity in Yeast and Human Cell Models

Autor: Caterina Peggion, Maria Lina Massimino, Roberto Stella, Raissa Bortolotto, Jessica Agostini, Arianna Maldi, Geppo Sartori, Fiorella Tonello, Alessandro Bertoli, Raffaele Lopreiato

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

TDP-43 is a nuclear protein involved in pivotal processes, extensively studied for its implication in neurodegenerative disorders. TDP-43 cytosolic inclusions are a common neuropathologic hallmark in amyotrophic lateral sclerosis (ALS) and related di

Externí odkaz: https://doaj.org/article/7141b76667ba49b8bcdd2988f374db35

The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor

Autor: Silvio C. E. Tosatto, Maria Pennuto, Geppo Sartori, Raffaele Lopreiato, Giovanni Minervini, Damiano Piovesan, Raissa Bortolotto, Antonella Falconieri

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Mutations of the von Hippel-Lindau (pVHL) tumor suppressor are causative of a familiar predisposition to develop different types of cancer. pVHL is mainly known for its role in regulating hypoxia-inducible factor 1-α (HIF-1α) degradation, thus modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f65e16981187b9b62d6269726015ec
https://doi.org/10.1101/2020.04.28.066084

A novel PMCA3 mutation in an ataxic patient with hypomorphic phosphomannomutase 2 (PMM2) heterozygote mutations: Biochemical characterization of the pump defect

Autor: Marta Nardella, Alessia Micalizzi, Raissa Bortolotto, Ginevra Zanni, Domenico Cieri, Francesca Vallese, Enrico Bertini, Raffaele Lopreiato, Ernesto Carafoli, Tito Calì, Giuseppe Zanotti, Mattia Vicario, Francesco Zonta, Dirk Lefeber, Enza Maria Valente, Marisa Brini

Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease, 1863, 3303-3312
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1863, 12, pp. 3303-3312

Item does not contain fulltext The neuron-restricted isoform 3 of the plasma membrane Ca(2+) ATPase plays a major role in the regulation of Ca(2+) homeostasis in the brain, where the precise control of Ca(2+) signaling is a necessity. Several functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078f287d2c332fc55901242a9a927494
http://hdl.handle.net/2066/182493