CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells.

Autor: Cazzaniga C; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland., Göder A; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland., Rainey MD; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland., Quinlan A; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland., Coughlan S; SFI Centre for Research Training in Genomics Data Science, University of Galway, Ireland., Bernard S; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Ireland., Santocanale C; Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.; SFI Centre for Research Training in Genomics Data Science, University of Galway, Ireland.

Publikováno v: The FEBS journal [FEBS J] 2024 Jul; Vol. 291 (14), pp. 3147-3168. Date of Electronic Publication: 2024 Mar 31.

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.

Autor: Papeo G; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Posteri H; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Borghi D; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Busel AA; Chemical Diversity Research Institute , Rabochaya St. 2 Khimki, Moscow Region 114401, Russia., Caprera F; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Casale E; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Ciomei M; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Cirla A; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Corti E; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., D'Anello M; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Fasolini M; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Forte B; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Galvani A; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Isacchi A; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Khvat A; Chemical Diversity Research Institute , Rabochaya St. 2 Khimki, Moscow Region 114401, Russia., Krasavin MY; Chemical Diversity Research Institute , Rabochaya St. 2 Khimki, Moscow Region 114401, Russia., Lupi R; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Orsini P; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Perego R; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Pesenti E; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Pezzetta D; Accelera Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Rainoldi S; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Riccardi-Sirtori F; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Scolaro A; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Sola F; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Zuccotto F; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Felder ER; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Donati D; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy., Montagnoli A; Oncology, Nerviano Medical Sciences Srl , Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Sep 10; Vol. 58 (17), pp. 6875-98. Date of Electronic Publication: 2015 Aug 26.

Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome.

Autor: Arroyo, Maria, Casas-Delucchi, Corella S, Pabba, Maruthi K, Prorok, Paulina, Pradhan, Sunil K, Rausch, Cathia, Lehmkuhl, Anne, Maiser, Andreas, Buschbeck, Marcus, Pasque, Vincent, Bernstein, Emily, Luck, Katja, Cardoso, M Cristina

Publikováno v: Nucleic Acids Research; 10/28/2024, Vol. 52 Issue 19, p11659-11688, 30p

520 NMS-P118, a Parp-1 selective inhibitor with efficacy in DNA repair deficient tumor models

Autor: Montagnoli, A., Rainoldi, S., Sola, F., Posteri, H., Lupi, R., Pesenti, E., Donati, D., Moll, J., Pezzetta, D., Papeo, G.

Publikováno v: In EJC Supplements 2010 8(7):166-166

Novel insights into the roles of Cdc7 in response to replication stress.

Autor: González‐Garrido, Cristina¹ (AUTHOR), Prado, Félix¹ (AUTHOR) felix.prado@cabimer.es

Publikováno v: FEBS Journal. Jun2023, Vol. 290 Issue 12, p3076-3088. 13p.