A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies.

Autor: Mundi PS; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Dela Cruz FS; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Grunn A; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Diolaiti D; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Mauguen A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Rainey AR; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Guillan K; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Siddiquee A; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., You D; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Realubit R; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Karan C; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Ortiz MV; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Douglass EF; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Accordino M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Mistretta S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Brogan F; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York., Bruce JN; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York., Caescu CI; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Carvajal RD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Crew KD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Decastro G; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Heaney M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Henick BS; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Hershman DL; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York., Hou JY; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Iwamoto FM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Jurcic JG; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Kiran RP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Surgery, Columbia University Irving Medical Center, New York, New York., Kluger MD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Surgery, Columbia University Irving Medical Center, New York, New York., Kreisl T; Department of Otolaryngology Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York., Lamanna N; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Lassman AB; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Lim EA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Manji GA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., McKhann GM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York., McKiernan JM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Neugut AI; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York., Olive KP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Rosenblat T; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Schwartz GK; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Shu CA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York., Sisti MB; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York.; Department of Otolaryngology Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York.; Department of Radiation Oncology, Columbia University Irving Medical Center, New York, New York., Tergas A; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Vattakalam RM; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Welch M; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Neurology, Columbia University Irving Medical Center, New York, New York., Wenske S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Urology, Columbia University Irving Medical Center, New York, New York., Wright JD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York., Canoll P; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York., Hibshoosh H; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York., Kalinsky K; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Winship Cancer Institute of Emory University and Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia., Aburi M; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York., Alvarez MJ; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; DarwinHealth Inc., New York, New York., Kung AL; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Califano A; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York.; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York.; J.P. Sulzberger Columbia Genome Center, Columbia University Irving Medical Center, New York, New York.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Jun 02; Vol. 13 (6), pp. 1386-1407.

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.

Autor: Alvarez MJ; Department of Systems Biology, Columbia University, New York, NY, USA.; DarwinHealth Inc, New York, NY, USA., Subramaniam PS; Department of Systems Biology, Columbia University, New York, NY, USA., Tang LH; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grunn A; Department of Systems Biology, Columbia University, New York, NY, USA., Aburi M; Department of Systems Biology, Columbia University, New York, NY, USA., Rieckhof G; Institute for Systems Genetics, New York University Langone Medical Center, New York, NY, USA., Komissarova EV; Department of Systems Biology, Columbia University, New York, NY, USA., Hagan EA; Department of Urology, Columbia University, New York, NY, USA., Bodei L; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Division of Pathology, European Institute of Oncology, Milan, Italy., Clemons PA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dela Cruz FS; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dhall D; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Diolaiti D; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fraker DA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ghavami A; PsychoGenics Inc., Tarrytown, NY, USA., Kaemmerer D; Department of General and Visceral Surgery, Zentralklinik, Bad Berka, Germany., Karan C; Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA., Kidd M; Wren Laboratories, Branford, CT, USA., Kim KM; Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Kim HC; Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Kunju LP; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA., Langel Ü; Department of Neurochemistry, the Arrhenius Laboratories for Nat. Sci., Stockholm University, Stockholm, Sweden.; Laboratory of Molecular Biotechnology, Institute of Technology, University of Tartu, Tartu, Estonia., Li Z; Falconwood Foundation, New York, NY, USA., Lee J; Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Li H; Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA., LiVolsi V; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pfragner R; Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria., Rainey AR; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Realubit RB; Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA., Remotti H; Department of Pathology, Columbia University, New York, NY, USA., Regberg J; Department of Neurochemistry, the Arrhenius Laboratories for Nat. Sci., Stockholm University, Stockholm, Sweden., Roses R; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rustgi A; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sepulveda AR; Department of Pathology, Columbia University, New York, NY, USA., Serra S; Department of Pathology, University Health Network, University of Toronto, Toronto, Canada., Shi C; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA., Yuan X; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Barberis M; Division of Pathology, European Institute of Oncology, Milan, Italy., Bergamaschi R; Division of Colon and Rectal Surgery, State University of New York, Stony Brook, NY, USA., Chinnaiyan AM; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Urology, University of Michigan Medical School, Ann Arbor, MI, USA., Detre T; Falconwood Foundation, New York, NY, USA., Ezzat S; Department of Pathology, University Health Network, University of Toronto, Toronto, Canada., Frilling A; Imperial College London, London, UK., Hommann M; Department of General and Visceral Surgery, Zentralklinik, Bad Berka, Germany., Jaeger D; Medical Oncology, National Center for Tumor Diseases Heidelberg, University Medical Center Heidelberg, Heidelberg, Germany., Kim MK; Mount Sinai School of Medicine, New York, NY, USA., Knudsen BS; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Kung AL; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Leahy E; PsychoGenics Inc., Tarrytown, NY, USA., Metz DC; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Milsom JW; Department of Surgery, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA., Park YS; Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Reidy-Lagunes D; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schreiber S; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Washington K; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA., Wiedenmann B; Department of Internal Medicine, Division of Gastroenterology, Charite, Universitätsmedizin Berlin, Berlin, Germany., Modlin I; Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA. imodlin@irvinmodlin.com., Califano A; Department of Systems Biology, Columbia University, New York, NY, USA. califano@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University, New York, NY, USA. califano@cumc.columbia.edu.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. califano@cumc.columbia.edu.; J.P. Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA. califano@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. califano@cumc.columbia.edu.

Publikováno v: Nature genetics [Nat Genet] 2018 Jul; Vol. 50 (7), pp. 979-989. Date of Electronic Publication: 2018 Jun 18.