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Amelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C

Autor: Vallianatos, Christina N., Raines, Brynne, Porter, Robert S., Bonefas, Katherine M., Wu, Michael C., Garay, Patricia M., Collette, Katie M., Seo, Young Ah, Dou, Yali, Keegan, Catherine E., Tronson, Natalie C., Iwase, Shigeki

Histone H3 lysine 4 methylation (H3K4me) is extensively regulated by seven writer and six eraser enzymes in mammals. Nine H3K4me enzymes are associated with neurodevelopmental disorders to date, indicating their important roles in the brain. Opposing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::5ff4d84dc9a71cefa0763b5a344ed149

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.

Autor: Haanen TJ; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Boock S; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Callahan CG; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Peris I; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Zawacki KP; University of Michigan-Ann Arbor, Ann Arbor, MI, United States., Raines B; University of Michigan-Ann Arbor, Ann Arbor, MI, United States., Nino CA; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Tran B; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Harold A; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Hodges Onishi G; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Hinderman M; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Dowdican A; University of Michigan-Ann Arbor, Ann Arbor, Michigan, United States., Huang W; Case Western Reserve University, Cleveland, Ohio, United States., Taylor DJ; Case Western Reserve University, Cleveland, OH, United States., Taylor SE; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States., Jackson MW; Comprehensive Cancer Center at Case Western Reserve University, Cleveland, OH, United States., DiFeo A; University of Michigan-Ann Arbor, Ann Arbor, MI, United States., O'Connor CM; Case Western Reserve University, Ann Arbor, MI, United States., Narla G; University of Michigan-Ann Arbor, Ann Arbor, MI, United States.

Publikováno v: Cancer research [Cancer Res] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.