Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rainer Netzer"'
Publikováno v:
SLAS Discovery. 11:57-64
A functional cell-based assay was developed using a generic proprietary assay protocol, based on a membrane-potential sensitive dye, for the identification of small-molecule antagonists against the Kv1.3 potassium ion channel. A high-throughput scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f884fe5ec9122826622893930e960ea
https://doi.org/10.1177/1087057105282712
https://doi.org/10.1177/1087057105282712
Publikováno v:
Drug Discovery Today. 6:78-84
The late detection of cardiotoxic side effects, such as QT prolongation, induced by compounds of pharmacological interest can dramatically impede drug discovery and development projects, and consequently increase their cost. The launch of new drugs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3615d330f072c9d086852b83b7c9c43
https://doi.org/10.1016/s1359-6446(00)01602-0
https://doi.org/10.1016/s1359-6446(00)01602-0
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 426:206-213
The barium current through voltage-dependent calcium channels was recorded from cultured rat cortical neurons with the whole-cell configuration of the patch-clamp technique. The maximal current evoked by depolarising pulses from -80 mV to 0 mV was di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263372ae5bdccf6acf23da0b5115dedd
https://doi.org/10.1007/bf00374773
https://doi.org/10.1007/bf00374773
Publikováno v:
European Journal of Pharmacology. 238:209-216
The effect of dextromethorphan on several types of cation currents in cultured rat cortical neurons and PC12 cells was studied by using the whole-cell configuration of the patch-clamp technique. The Ba2+ current through L- and N-type Ca2+ channels wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32a3377a0471aee90312ad08f134527
https://doi.org/10.1016/0014-2999(93)90849-d
https://doi.org/10.1016/0014-2999(93)90849-d
Autor:
Rainer Netzer, Nadine Ahrens, Irene Schlobohm, Clemens Möller, Christian Kirchhoff, Heike Deisemann
Publikováno v:
Journal of cardiovascular pharmacology. 52(6)
A common over-the-counter (OTC) non-opioid antitussive drug, clobutinol, was recently withdrawn from the market due to its potential to induce cardiac arrhythmias by a blockade of the potassium channel coded by the human ether-a-go-go-related gene (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1de7275fa972a0236de6c938a0cb88
https://pubmed.ncbi.nlm.nih.gov/19034038
https://pubmed.ncbi.nlm.nih.gov/19034038
Autor:
Rainer Netzer, Clemens Möller
Publikováno v:
European journal of pharmacology. 532(1-2)
Steroids are known to exert direct and indirect effects on cardiovascular functions, and women have been found to be more susceptible to QT prolongation than men. Although many clinical studies have been performed, the effects of steroids on cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb0a4a1c68c9f119e79ee967fc8d782
https://pubmed.ncbi.nlm.nih.gov/16480714
https://pubmed.ncbi.nlm.nih.gov/16480714
Publikováno v:
Current opinion in drug discoverydevelopment. 6(4)
Within the past few years, the high-throughput screening (HTS) of compounds targeting cardiac ion channels has been primarily focused on the testing of the HERG channel, which is involved in the termination of cardiac action potential. Interaction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5539836af8ed60719a87f2470120b59f
https://pubmed.ncbi.nlm.nih.gov/12951809
https://pubmed.ncbi.nlm.nih.gov/12951809
Autor:
Rainer Netzer
Publikováno v:
Drug discovery today. 6(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9899978bd70e57ac2122008bfe0861a0
https://pubmed.ncbi.nlm.nih.gov/11677164
https://pubmed.ncbi.nlm.nih.gov/11677164
Autor:
Chris Rundfeldt, Rainer Netzer
Publikováno v:
Arzneimittel-Forschung. 50(12)
Retigabine (N-(2-amino-4-(4-fluorobenzylamino)phenyl) carbamic acid ethyl ester, CAS 150812-12-7, D-23129) is a novel anticonvulsant currently undergoing phase II clinical trials. The compound was shown to possess broad spectrum and potent anticonvul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6510ec835cfc678960229389ac3e8d
https://pubmed.ncbi.nlm.nih.gov/11190770
https://pubmed.ncbi.nlm.nih.gov/11190770
Publikováno v:
European journal of pharmacology. 406(3)
We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ba411ab45a77e1b3b23f5414f56c8
https://pubmed.ncbi.nlm.nih.gov/11040340
https://pubmed.ncbi.nlm.nih.gov/11040340