Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rainer Munschauer"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1683-1686
A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5d34c40184ac8f37749ad47353480f
https://doi.org/10.1016/s0960-894x(02)00195-6
https://doi.org/10.1016/s0960-894x(02)00195-6
Autor:
Rainer Munschauer, Gerhard Maas
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830d3c2b5a4842a7a3b6870f987b69d2
https://doi.org/10.1002/chin.199121080
https://doi.org/10.1002/chin.199121080
Autor:
Rainer Munschauer, Gerhard Maas
Publikováno v:
ChemInform. 23
(1-Diazo-2-oxoalkyl)silanes 1a–h react with cyclopropene 4 to form 2-silyl-2,3-diazabicyclo[3.1.0]hex-3-enes 5 and/or 1-silyll-1,4-dihydropyridazines 6. In most cases, a temperature- and solvent-dependent equilibrium 5 ⇄ 6 maintained by an N N′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034a86b834721a2edd18df081afcb218
https://doi.org/10.1002/chin.199235074
https://doi.org/10.1002/chin.199235074
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9872f7291e57dc88010089564a1598f3
https://doi.org/10.1002/chin.199528120
https://doi.org/10.1002/chin.199528120
Publikováno v:
ChemInform. 33
A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available lck inhibitor which inhibited T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19fb9217b0bd2e71ff6165fcf9328be
https://doi.org/10.1002/chin.200240242
https://doi.org/10.1002/chin.200240242
Autor:
Gerhard Maas, Rainer Munschauer
Publikováno v:
Chemische Berichte. 125:1227-1234
(1-Diazo-2-oxoalkyl)silanes 1a–h react with cyclopropene 4 to form 2-silyl-2,3-diazabicyclo[3.1.0]hex-3-enes 5 and/or 1-silyll-1,4-dihydropyridazines 6. In most cases, a temperature- and solvent-dependent equilibrium 5 ⇄ 6 maintained by an N N′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7316776f4c08f423ecd6fc1606014327
https://doi.org/10.1002/cber.19921250532
https://doi.org/10.1002/cber.19921250532
Autor:
Andrew F. Burchat, David J. Calderwood, Gavin C. Hirst, Nicholas J. Holman, David N. Johnston, Rainer Munschauer, Paul Rafferty, Gerald B. Tometzki
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81264efe1129dddb06c11cec1de5b8c3
https://doi.org/10.1002/chin.200052134
https://doi.org/10.1002/chin.200052134
Autor:
David J. Calderwood, Sheldon E. Ratnofsky, David N. Johnston, Rainer Munschauer, Joanne Kamens, Paul Rafferty, Richard W. Dixon, Arnold Lee D
Publikováno v:
ChemInform. 31
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f39dc429616c17c021c109c99f9cd8
https://doi.org/10.1002/chin.200052133
https://doi.org/10.1002/chin.200052133
Autor:
Richard W. Dixon, Arnold Lee D, David N. Johnston, Rainer Munschauer, Sheldon E. Ratnofsky, David J. Calderwood, Paul Rafferty, Joanne Kamens
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(19)
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9344bd3980e9804ad2572318b524616
https://pubmed.ncbi.nlm.nih.gov/11012021
https://pubmed.ncbi.nlm.nih.gov/11012021
Autor:
Gerhard Maas, Rainer Munschauer
Publikováno v:
Angewandte Chemie. 103:312-314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62f48ce0a0d08643d432e84f5b442698
https://doi.org/10.1002/ange.19911030313
https://doi.org/10.1002/ange.19911030313