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pro vyhledávání: '"Rainer Leben"'
Autor:
Urs Wiedemann, Prisca Boisguerin, Gerd Krause, Dietmar Leitner, Rainer Leben, Karin Moelling, Rudolf Volkmer-Engert, Hartmut Oschkinat
Publikováno v:
Journal of Molecular Biology. 343:703-718
Transient macromolecular complexes are often formed by protein-protein interaction domains (e.g. PDZ, SH2, SH3, WW) which recognize linear sequence motifs with in vitro affinities typically in the micromolar range. The analysis of the resulting inter
Autor:
Rainer Leben, Rudolf Volkmer-Engert, Karin Moelling, Prisca Boisguerin, Bernhard Ay, Gerald Radziwill, Liying Dong
Publikováno v:
Chemistry & Biology. 11:449-459
SPOT synthesis permits parallel synthesis and screening of thousands of cellulose membrane-bound peptides to study protein-protein interactions in a proteomic context. Recognition of C-terminal residues is one of the most common binding features of P
Publikováno v:
Seminars in Thrombosis and Hemostasis. 27:349-356
Hirudin, the anticoagulatory polypeptide of the leech Hirudo medicinalis, strongly inhibits thrombus formation by specifically interacting with thrombin. For diagnostic purposes, hirudin should be superior to other anticlotting compounds because it o