Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rainer Harhammer"'
Autor:
Heinrich Repke, Monika Boomgaarden, Reinhard Sohr, Rainer Harhammer, Ute Schäfer, Tilmann Ott, Peter Henklein
Publikováno v:
Journal of Neurochemistry. 62:1426-1431
The structural requirements for the selective binding of cholecystokinin-8 (CCK-8)-related peptides to peripheral (CCKA) receptors are not sufficiently understood. In this study, the interaction of a series of newly shortened analogues of CCK-8 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1292273647f70833b7a4f8ad72f418c
https://doi.org/10.1046/j.1471-4159.1994.62041426.x
https://doi.org/10.1046/j.1471-4159.1994.62041426.x
Autor:
Daniela Leopoldt, Rainer Harhammer, Günter Schultz, Bernd Nürnberg, Torsten Exner, Christian Harteneck
Publikováno v:
Biochemical Journal. 319:165-171
G12 and G13 are insufficiently characterized pertussis toxin-insensitive G-proteins. Here, we describe the isolation of G alpha 12 from rat brain membranes. G alpha 12 was purified to apparent homogeneity by three steps of conventional chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1bc756a04a43f44dbcf22647777bca
https://doi.org/10.1042/bj3190165
https://doi.org/10.1042/bj3190165
Publikováno v:
Biochemical Journal. 318:717-722
We previously reported that, in the membranes of HL-60 cells during activation of G-proteins, a phosphate transfer reaction occurs which involves transient G-protein beta subunit (G beta) phosphorylation [Wieland, Nürnberg, Ulibarri, Kaldenberg-Stas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83abeca991da11e121fac602be52cedf
https://doi.org/10.1042/bj3180717
https://doi.org/10.1042/bj3180717
Autor:
W Schunack, Rainer Harhammer, Roland Seifert, A. Hagelüken, Lore Grünbaum, Bernd Nürnberg, Günter Schultz, Christian Leschke, Jan F. Klinker
Publikováno v:
Biochemical Pharmacology. 49:901-914
In dibutyryl cAMP-differentiated human leukemia (HL-60) cells, the potent histamine H1-receptor agonist, 2-(3-chlorophenyl)histamine, activates pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G-proteins) of the Gi-subfamily by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9f0ec6ce2d4ab43863ab4561b7306b
https://doi.org/10.1016/0006-2952(94)00514-m
https://doi.org/10.1016/0006-2952(94)00514-m
Publikováno v:
Pharmaceutical Research. 12:366-369
Isolated heterotrimeric G-proteins exhibit full biological activity when reconstituted into liposomes. Here, we investigated the non-ionic surfactant macrogol-260-cetylstearylether (TA 6) as an efficient vehicle for the reconstitution of G-proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37fa7725f4035bf7429e626f88c80ab7
https://doi.org/10.1023/a:1016296300654
https://doi.org/10.1023/a:1016296300654
Publikováno v:
Biochemical and Biophysical Research Communications. 204:835-840
G13 belongs to the G12-subfamily of heterotrimeric regulatory G-proteins. Employing specific antibodies, we isolated G alpha 13 from bovine brain by a four-step purification protocol combining conventional and affinity chromatography. The use of ethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ca77832dfafe99cdcee2fa7aa8d6ab
https://doi.org/10.1006/bbrc.1994.2535
https://doi.org/10.1006/bbrc.1994.2535
Autor:
A. Soling, G. Schultz, Karsten Spicher, Andrea Zobel, Rainer Harhammer, Frank Kalkbrenner, Bernd Nürnberg
Publikováno v:
Biochemical and Biophysical Research Communications. 198:906-914
The cDNAs of two putatively pertussis toxin-insensitive G-protein alpha-subunits, alpha 12 and alpha 13, were recently cloned. mRNA analyses based on the reverse transcriptase polymerase chain reaction indicated a widespread distribution of both mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616dcce532f7784d34718003e140749b
https://doi.org/10.1006/bbrc.1994.1129
https://doi.org/10.1006/bbrc.1994.1129
Publikováno v:
The Journal of biological chemistry. 273(8)
Lysophosphatidic acid (LPA) utilizes a G-protein-coupled receptor to activate the small GTP-binding protein Rho and to induce rapid remodeling of the actin cytoskeleton. We studied the signal transduction from LPA receptors to Rho activation. Analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fc02d5fa4c2f54d08b008869e085d2
https://pubmed.ncbi.nlm.nih.gov/9468525
https://pubmed.ncbi.nlm.nih.gov/9468525
Publikováno v:
FEBS letters. 399(3)
Gbetagamma dimers of heterotrimeric G proteins have been shown to be important for the translocation of cytosolic proteins to membranes. The involvement of Gbetagamma in those signaling processes mediated by small GTP-binding proteins of the Rho fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0476d185a553a7097311583a05c0557
https://pubmed.ncbi.nlm.nih.gov/8985147
https://pubmed.ncbi.nlm.nih.gov/8985147
Autor:
Frank Kalkbrenner, Daniela Leopoldt, Alexander G. Obukhov, Bernd Nürnberg, Rainer Harhammer, Andrea Zobel, Christian Harteneck, Andreas Lückhoff, Günter Schultz
Publikováno v:
The EMBO journal. 15(21)
G proteins of the Gq/11 subfamily functionally couple cell surface receptors to phospholipase C beta (PLC beta) isoforms. Stimulation of PLC beta induces Ca2+ elevation by inositol 1,4,5-trisphosphate (InsP3)-mediated Ca2+ release and store-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c6c3c13e949f7f6f00be62177011de
https://pubmed.ncbi.nlm.nih.gov/8918461
https://pubmed.ncbi.nlm.nih.gov/8918461