Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Rainer H Kohler"'
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Noah Enbergs, Elias A. Halabi, Anne‐Gaëlle Goubet, Kelton Schleyer, Ina R. Fredrich, Rainer H. Kohler, Christopher S. Garris, Mikaël J. Pittet, Ralph Weissleder
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Tumor‐associated macrophages (TAM) are a diverse population of myeloid cells that are often abundant and immunosuppressive in human cancers. CXCL9Hi TAM has recently been described to have an antitumor phenotype and is linked to immune che
Externí odkaz:
https://doaj.org/article/9ae6b327a4c14e03ba83a5d83d68b25c
Autor:
Anastasia Korolj, Rainer H. Kohler, Ella Scott, Elias A. Halabi, Kilean Lucas, Jonathan C.T. Carlson, Ralph Weissleder
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Intravital microscopy (IVM) allows spatial and temporal imaging of different cell types in intact live tissue microenvironments. IVM has played a critical role in understanding cancer biology, invasion, metastases, and drug development. One
Externí odkaz:
https://doaj.org/article/9d1c2c10032546648813e41d837c3f55
Autor:
Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modula
Externí odkaz:
https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a84
Autor:
Hsin-Wei Liao, Christopher Garris, Christina Pfirschke, Steffen Rickelt, Sean Arlauckas, Marie Siwicki, Rainer H. Kohler, Ralph Weissleder, Vibeke Sundvold-Gjerstad, Baldur Sveinbjørnsson, Øystein Rekdal, Mikael J. Pittet
Publikováno v:
Cell Stress, Vol 3, Iss 11, Pp 348-360 (2019)
LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of canc
Externí odkaz:
https://doaj.org/article/3c2d5b260fbe4adb94f8a76380519ac6
Autor:
Miles A. Miller, Bjorn Askevold, Hannes Mikula, Rainer H. Kohler, David Pirovich, Ralph Weissleder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Palladium (Pd) is a well-known catalyst in organic chemistry but its use in nanomedicine is limited. Here, the authors design a Pd nanoparticle that triggers the activation of an antitumour prodrugin vivo, which shows efficacy and improves toxicity c
Externí odkaz:
https://doaj.org/article/b929185b46444f18bedc3e0efd655654
Autor:
Jina Ko, Martin Wilkovitsch, Juhyun Oh, Rainer H. Kohler, Evangelia Bolli, Mikael J. Pittet, Claudio Vinegoni, David B. Sykes, Hannes Mikula, Ralph Weissleder, Jonathan C. T. Carlson
Publikováno v:
Nat Biotechnol
Cells in complex organisms undergo frequent functional changes, but few methods allow comprehensive longitudinal profiling of living cells. Here we introduce scission-accelerated fluorophore exchange (SAFE), a method for multiplexed temporospatial im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032b742d047621608767c7cfd5cbd273
https://doi.org/10.1038/s41587-022-01339-6
https://doi.org/10.1038/s41587-022-01339-6
Autor:
Mikael J. Pittet, Allon M. Klein, Ralph Weissleder, Virginia Savova, Rainer H. Kohler, Maaz S. Ahmed, Jeremy Quintana, Michael F. Cuccarese, Christopher B. Rodell, Angela N. Marquard, Melissa M. Sprachman, Jeremy Gungabeesoon, Marie Siwicki, Ruben Bill, Yunkang Lin, Nicolas A. Gort-Freitas, Steffen Rickelt, Angela E. Zou, Marius Messemaker, Camilla Engblom, Rapolas Zilionis, Christina Pfirschke
Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03be49f542113058bc6ec50af244fe65
https://doi.org/10.1158/2326-6066.22544211
https://doi.org/10.1158/2326-6066.22544211
Autor:
Mikael J. Pittet, Allon M. Klein, Ralph Weissleder, Virginia Savova, Rainer H. Kohler, Maaz S. Ahmed, Jeremy Quintana, Michael F. Cuccarese, Christopher B. Rodell, Angela N. Marquard, Melissa M. Sprachman, Jeremy Gungabeesoon, Marie Siwicki, Ruben Bill, Yunkang Lin, Nicolas A. Gort-Freitas, Steffen Rickelt, Angela E. Zou, Marius Messemaker, Camilla Engblom, Rapolas Zilionis, Christina Pfirschke
Macrophages often abound within tumors, express colony-stimulating factor 1 receptor (CSF1R), and are linked to adverse patient survival. Drugs blocking CSF1R signaling have been used to suppress tumor-promoting macrophage responses; however, their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe5dea6561f080330bae8bd2e02da5
https://doi.org/10.1158/2326-6066.c.6550572.v1
https://doi.org/10.1158/2326-6066.c.6550572.v1
The heterogeneous delivery of drugs in tumors is an established process contributing to variability in treatment outcome. Despite the general acceptance of variable delivery, the study of the underlying causes is challenging, given the complex tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c8a644487522c2f0c4ccdb12a0c604
https://doi.org/10.1158/1535-7163.c.6536340.v1
https://doi.org/10.1158/1535-7163.c.6536340.v1