A Genomics-Based Classification of Human Lung Tumors

Autor: Sabine Merkelbach-Bruse, Odd Terje Brustugun, Marius Lund-Iversen, Philipp A. Schnabel, Hans Hoffmann, Katharina Koenig, Kato Kambartel, Matthias Scheffler, Reinhard Buettner, Harry J.M. Groen, Jana Fassunke, C. Ligorio, Helen Kuenstlinger, Peter Nuemberg, Sylvie Lantuejoul, William Pao, Philippe Girard, Khosro Hekmat, Johannes Berg, Franziska Gabler, Winfried Randerath, Åslaug Helland, Joerg Saenger, Andreas Schlesinger, Elisabeth Brambilla, Lucia Nogova, Vito Michele Fazio, Monika Serke, Lucia Anna Muscarella, Ines Wilkening, Walburga Engel-Riedel, Sven Perner, Ilona Dahmen, Erich Stoelben, Steinar Solberg, Benjamin Solomon, Hans-Ulrich Schildhaus, Stefan Krueger, Lisa Meffert, Peter M. Schneider, Stefania Damiani, Elke Binot, Katja Schmitz, Toni-Maree Rogers, Ali-Nuri Huenerlituerkoglu, Ulrich Lang, Janine Altmueller, Hannie Sietsma, Chau Nguyen, Lynnette Fernandez-Cuesta, Pierre Validire, Federico Cappuzzo, Christian Mueller, Ulrich Gerigk, Gad Getz, Dirk Behringer, Christian Mattonet, Xin Lu, Wim Timens, Roman K. Thomas, Philippe Lorimier, Masyar Gardizi, Yuan Chen, William D. Travis, Thomas Zander, Prudence A. Russell, Danila Seidel, Marc Bos, Michaela Angelika Kleine, Egbert F. Smit, Matthias Heldwein, Corinna Ludwig, Russell Hyde, Scott L. Carter, Peter J.F. Snijders, Kerstin Albus, Roland Schnell, Alex Soltermann, Michael Hallek, Wolfgang Galetke, Eray Goekkurt, Benjamin Besse, Frauke Leenders, John K. Field, Matthew D. Wilkerson, Roopika Menon, Markus Litt-Lampe, Silvia Querings, Konrad Frank, Yon-Dschun Ko, Holger Moch, Denis Moro-Sibilot, Zoe Wainer, Erik Thunnissen, Lukas C. Heukamp, Walter Weder, Danille A. M. Heideman, Stephan Schmitz, Karin Toepelt, Rainer Kappes, Juergen Wolf, Ingelore Boessmann, Gavin M. Wright, Rainer Fricke, Thomas Muley, Martin L. Sos, Joachim H. Clement, Wolfgang Schulte, Christian Brambilla, Sascha Ansén, Viktor Achter, Jean-Charles Soria, D. Neil Hayes, Martin Peifer, Marcel Reiser, Magdalena Bogus

Publikováno v: Seidel, D, Zander, T, Heukamp, L C, Peifer, M, Bos, M, Fernandez-Cuesta, L, Leenders, F, Lu, X, Ansen, S, Gardizi, M, Nguyen, C, Berg, J, Russell, P, Wainer, Z, Schildhaus, H U, Rogers, T M, Solomon, B, Pao, W, Carter, S L, Getz, G, Hayes, D N, Wilkerson, M D, Thunnissen, E, Travis, W D, Perner, S, Wright, G, Brambilla, E, Buttner, R, Wolf, J, Gabler, F, Wilkening, I, Muller, C, Dahmen, I, Menon, R, Konig, K, Albus, K, Merkelbach-Bruse, S, Fassunke, J, Schmitz, K, Kuenstlinger, H, Kleine, M A, Binot, E, Querings, S, Altmuller, J, Bossmann, I, Numberg, P, Schneider, P M, Bogus, M, Soltermann, A, Moch, H, Brustugun, O T, Solberg, S, Lund-Iversen, M, Helland, A, Muley, T, Hoffmann, H, Schnabel, P A, Chen, Y, Groen, H, Timens, W, Sietsma, H, Clement, J H, Weder, W, Sanger, J, Stoelben, E, Ludwig, C, Engel-Riedel, W, Smit, E F, Heideman, D A M, Snijders, P J F, Nogova, L, Sos, M L, Mattonet, C, Topelt, K, Scheffler, M, Goekkurt, E, Kappes, R, Kruger, S, Kambartel, K, Behringer, D, Schulte, W, Galetke, W, Randerath, W, Heldwein, M, Schlesinger, A, Serke, M, Hekmat, K, Frank, K F, Schnell, R, Reiser, M, Hunerliturkoglu, A N, Schmitz, S, Meffert, L, Ko, Y D, Litt-Lampe, M, Gerigk, U, Fricke, R, Besse, B, Brambilla, C, Lantuejoul, S, Lorimier, P, Moro-Sibilot, D, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J K, Hyde, R, Validire, P, Girard, P, Muscarella, L A, Fazio, V M, Hallek, M, Soria, J C, Achter, V, Lang, U & Thomas, R K 2013, ' A Genomics-Based Classification of Human Lung Tumors ', Science Translational Medicine, vol. 5, no. 209, pp. 209ra153 . https://doi.org/10.1126/scitranslmed.3006802
Science Translational Medicine; Vol 5
Science Translational Medicine, 5(209). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 5(209). American Association for the Advancement of Science

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66843d0f2a6ec2231d73d891ddfa7d52
https://doi.org/10.1126/scitranslmed.3006802

Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome

Autor: Wolfgang Wintermeyer, L. Kuhn, Rainer Fricke, Marina V. Rodnina

Publikováno v: Europe PubMed Central
EMBO Journal

The mechanisms by which elongation factor Tu (EF-Tu) promotes the binding of aminoacyl-tRNA to the A site of the ribosome and, in particular, how GTP hydrolysis by EF-Tu is triggered on the ribosome, are not understood. We report steady-state and tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e609121cf991a5ff85a97d023a5b193
https://doi.org/10.1002/j.1460-2075.1995.tb07259.x

Kinetic Fluorescence Study on EF-Tu-Dependent Binding of Phe-tRNAPhe to the Ribosomal a Site

Autor: Marina V. Rodnina, Wolfgang Wintermeyer, Rainer Fricke

Publikováno v: The Translational Apparatus ISBN: 9781461360216

The elongation cycle of ribosomal protein synthesis begins with the binding of the substrate, aminoacyl-tRNA, to the A site of the ribosome. The reaction is a quite complex process which involves an enzyme, elongation factor Tu (EF-Tu), and GTP. It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e80eb23bda620ca29a8b4f3aa95aeb2
https://doi.org/10.1007/978-1-4615-2407-6_30