Výsledky vyhledávání - "Rainer B Lanz"

Akademický článek

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.

Autor: Yasmin M Vasquez, Xiaoqiu Wang, Margeaux Wetendorf, Heather L Franco, Qianxing Mo, Tianyuan Wang, Rainer B Lanz, Steven L Young, Bruce A Lessey, Thomas E Spencer, John P Lydon, Francesco J DeMayo

Publikováno v: PLoS Genetics, Vol 14, Iss 11, p e1007787 (2018)

Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful in vitro fertilization cycles. Here, we

Externí odkaz: https://doaj.org/article/110771854d64491491c0b8d45fe3adac

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Akademický článek

The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.

Autor: Ramakrishna Kommagani, Maria M Szwarc, Yasmin M Vasquez, Mary C Peavey, Erik C Mazur, William E Gibbons, Rainer B Lanz, Francesco J DeMayo, John P Lydon

Publikováno v: PLoS Genetics, Vol 12, Iss 4, p e1005937 (2016)

Progesterone, via the progesterone receptor (PGR), is essential for endometrial stromal cell decidualization, a cellular transformation event in which stromal fibroblasts differentiate into decidual cells. Uterine decidualization supports embryo impl

Externí odkaz: https://doaj.org/article/bc15f686e93b488fa1328e979089f2ca

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Akademický článek

A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor’s transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums f

Externí odkaz: https://doaj.org/article/116dab8ea7be413e937452d604e585f3

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Akademický článek

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.

Autor: Michael J Large, Margeaux Wetendorf, Rainer B Lanz, Sean M Hartig, Chad J Creighton, Michael A Mancini, Ertug Kovanci, Kuo-Fen Lee, David W Threadgill, John P Lydon, Jae-Wook Jeong, Francesco J DeMayo

Publikováno v: PLoS Genetics, Vol 10, Iss 6, p e1004451 (2014)

Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. Th

Externí odkaz: https://doaj.org/article/aa482490e83040538b59855dac1867be

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Akademický článek

Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes.

Autor: Amin R Mazloom, Ruth Dannenfelser, Neil R Clark, Arsen V Grigoryan, Kathryn M Linder, Timothy J Cardozo, Julia C Bond, Aislyn D W Boran, Ravi Iyengar, Anna Malovannaya, Rainer B Lanz, Avi Ma'ayan

Publikováno v: PLoS Computational Biology, Vol 7, Iss 12, p e1002319 (2011)

Coregulator proteins (CoRegs) are part of multi-protein complexes that transiently assemble with transcription factors and chromatin modifiers to regulate gene expression. In this study we analyzed data from 3,290 immuno-precipitations (IP) followed

Externí odkaz: https://doaj.org/article/0cee1b71d698463991acce0891a5005a

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SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2

Autor: Andrés Hernández-García, Katherine E Pendleton, Sangbae Kim, Yumei Li, Bum J Kim, Hitisha P Zaveri, Valerie K Jordan, Aliska M Berry, M Cecilia Ljungberg, Rui Chen, Rainer B Lanz, Daryl A Scott

Publikováno v: Human Molecular Genetics.

SOX7 is a transcription factor-encoding gene located in a region on chromosome 8p23.1 that is recurrently deleted in individuals with ventricular septal defects (VSDs). We have previously shown that Sox7−/− embryos die of heart failure around E11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::368181fa8752a662f186540cd0a9a609
https://doi.org/10.1093/hmg/ddad050

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Data from HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes

Autor: Bert W. O'Malley, Carolyn L. Smith, David M. Lonard, Susan G. Hilsenbeck, Anna Tsimelzon, Chad J. Creighton, Nicholas Mitsiades, Subhamoy Dasgupta, Brian York, Rainer B. Lanz, Bryan C. Nikolai

Approximately 20% of early-stage breast cancers display amplification or overexpression of the ErbB2/HER2 oncogene, conferring poor prognosis and resistance to endocrine therapy. Targeting HER2+ tumors with trastuzumab or the receptor tyrosine kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e349976f373062bde25db43d25a58
https://doi.org/10.1158/0008-5472.c.6507512

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