Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Rainer A, Böckmann"'
Autor:
Dominik Ruppelt, Marius F. W. Trollmann, Taulant Dema, Sebastian N. Wirtz, Hendrik Flegel, Sophia Mönnikes, Stephanie Grond, Rainer A. Böckmann, Claudia Steinem
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Recently, a novel cyclo-heptapeptide composed of alternating d,l-amino acids and a unique thiazolidine heterocycle, called lugdunin, was discovered, which is produced by the nasal and skin commensal Staphylococcus lugdunensis. Lugdunin displ
Externí odkaz:
https://doaj.org/article/38880531d1434ebb8518ed3032bab98c
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Biological membranes, composed mainly of phospholipids and cholesterol, play a vital role as cellular barriers. They undergo localized reshaping in response to environmental cues and protein interactions, with the energetics of deformations
Externí odkaz:
https://doaj.org/article/f1c3c6db67b14d7195e5945cf06abbb5
Autor:
Maithily S. Nanadikar, Ana M. Vergel Leon, Jia Guo, Gijsbert J. van Belle, Aline Jatho, Elvina S. Philip, Astrid F. Brandner, Rainer A. Böckmann, Runzhu Shi, Anke Zieseniss, Carla M. Siemssen, Katja Dettmer, Susanne Brodesser, Marlen Schmidtendorf, Jingyun Lee, Hanzhi Wu, Cristina M. Furdui, Sören Brandenburg, Joseph R. Burgoyne, Ivan Bogeski, Jan Riemer, Arpita Chowdhury, Peter Rehling, Tobias Bruegmann, Vsevolod V. Belousov, Dörthe M. Katschinski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, w
Externí odkaz:
https://doaj.org/article/46b0dc091943496094992a4e0a96de5f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Detailed knowledge on the formation of biomembrane domains, their structure, composition, and physical characteristics is scarce. Despite its frequently discussed importance in signaling, e.g., in obtaining localized non-homogeneous receptor composit
Externí odkaz:
https://doaj.org/article/f1b32974cf814caa91705ed1c9a3f7ad
Autor:
Jennifer J. Lühr, Nils Alex, Lukas Amon, Martin Kräter, Markéta Kubánková, Erdinc Sezgin, Christian H. K. Lehmann, Lukas Heger, Gordon F. Heidkamp, Ana-Sunčana Smith, Vasily Zaburdaev, Rainer A. Böckmann, Ilya Levental, Michael L. Dustin, Christian Eggeling, Jochen Guck, Diana Dudziak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system. Upon sensing pathogenic material in their environment, DCs start to mature, which includes cellular processes, such as antigen uptake, processing and presentation,
Externí odkaz:
https://doaj.org/article/7bd94d41531748c0a76c75f16f85c8c1
Autor:
Christine Silvia Gibhardt, Sabrina Cappello, Rajesh Bhardwaj, Romana Schober, Sonja Agnes Kirsch, Zuriñe Bonilla del Rio, Stefan Gahbauer, Anna Bochicchio, Magdalena Sumanska, Christian Ickes, Ioana Stejerean-Todoran, Miso Mitkovski, Dalia Alansary, Xin Zhang, Aram Revazian, Marc Fahrner, Victoria Lunz, Irene Frischauf, Ting Luo, Daria Ezerina, Joris Messens, Vsevolod Vadimovich Belousov, Markus Hoth, Rainer Arnold Böckmann, Matthias Albrecht Hediger, Rainer Schindl, Ivan Bogeski
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108292- (2020)
Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications. However, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/9aa210ab347a4829a53ce714c6a1e9f1
Autor:
Oskar Engberg, Anna Bochicchio, Astrid F. Brandner, Ankur Gupta, Simli Dey, Rainer A. Böckmann, Sudipta Maiti, Daniel Huster
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc. possibly modulate this lateral segregation. The small aromatic neurotransmit
Externí odkaz:
https://doaj.org/article/8fc82a15c80c4f4596127fdbc4026289
Autor:
Lisa Ebersberger, Torben Schindler, Sonja A. Kirsch, Kristyna Pluhackova, Alexandra Schambony, Tilo Seydel, Rainer A. Böckmann, Tobias Unruh
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Lipids and proteins, as essential components of biological cell membranes, exhibit a significant degree of freedom for different kinds of motions including lateral long-range mobility. Due to their interactions, they not only preserve the cellular me
Externí odkaz:
https://doaj.org/article/f84b47c878f14587901560614b27df7a
Publikováno v:
Biophysical Journal. 121:3927-3939
Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics simulations as a computational microscope, we provide an atomistic view of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cba71d58915113ecbdc696c28aada0
https://doi.org/10.1016/j.bpj.2022.08.037
https://doi.org/10.1016/j.bpj.2022.08.037
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antigen binding to B-cell antigen receptors (BCRs) followed by signaling initiates the humoral immune response. The signaling is intimately coupled to nanoclustering of BCRs and their sorting to specific membrane domains, a process that is ruled by i
Externí odkaz:
https://doaj.org/article/13c2baee772342ae9f9acc99fbd60aea