R Shiny App for the Automated Deconvolution of NMR Spectra to Quantify the Solid-State Forms of Pharmaceutical Mixtures

Autor: Piotr Prostko, Jeroen Pikkemaat, Philipp Selter, Michail Lukaschek, Rainer Wechselberger, Tatsiana Khamiakova, Dirk Valkenborg

Publikováno v: Metabolites, Vol 12, Iss 12, p 1248 (2022)

Bioavailability and chemical stability are important characteristics of drug products that are strongly affected by the solid-state structure of the active pharmaceutical ingredient (API). In pharmaceutical development and quality control activities,

Externí odkaz: https://doaj.org/article/7e9867c5b1c74934b00680bd261b8e67

Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products

Autor: Tom Atherton, Carl Heatherington, Ulrike Rieder, Robert Peter, Thomas De Vijlder, Rainer Wechselberger, Francis Ring, Joerg Hoernschemeyer, Jessica A. Stolee, David Benstead, Ayman Charaf, Hong Jiang, Daniel C. Capaldi, Nadim Akhtar

Publikováno v: Nucleic Acid Therapeutics. 30:249-264

A risk-based approach for routine identity testing of therapeutic oligonucleotide drug substances and drug products is described. Risk analysis of solid-phase oligonucleotide synthesis indicates that intact mass measurement is a powerful technique fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25dac9cb2bebc07dd39c91980bc3e71
https://doi.org/10.1089/nat.2020.0878

NMR studies on structure and dynamics of the monomeric derivative of BS-RNase: new insights for 3D domain swapping.

Autor: Roberta Spadaccini, Carmine Ercole, Maria A Gentile, Domenico Sanfelice, Rolf Boelens, Rainer Wechselberger, Gyula Batta, Andrea Bernini, Neri Niccolai, Delia Picone

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29076 (2012)

Three-dimensional domain swapping is a common phenomenon in pancreatic-like ribonucleases. In the aggregated state, these proteins acquire new biological functions, including selective cytotoxicity against tumour cells. RNase A is able to dislocate b

Externí odkaz: https://doaj.org/article/d88c0885ac7e46de8a51d8d34b4ea61c

Practical Synthesis of (2′R)-2′-Deoxy-2′-C-methyluridine by Highly Diastereoselective Homogeneous Hydrogenation

Autor: Ulrike Nettekoven, Jaak Langens, Tim Hugo Maria Jonckers, Ioannis N. Houpis, Haisheng Qu, Koen Vandyck, Renmao Liu, Vittorio Farina, Rainer Wechselberger, Nico Smets, Karl Magnus Nilsson, Youchu Wang, Pierre Raboisson, Tingting Xiao, Wim A. A. Vermeulen, Sébastien Lemaire

Publikováno v: The Journal of Organic Chemistry. 76:297-300

Diastereoselective hydrogenation of 2'-deoxy-2'-exo-methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfac363459d5399038157a0cc8de662
https://doi.org/10.1021/jo101822j

GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900MHz NMR analysis

Autor: C.A.G.M. Weijers, Rainer Wechselberger, Anne P. Tio-Gillen, Michel Gilbert, Bart C. Jacobs, Hubert P. Endtz, Dion E.A. Florack, Han Zuilhof, Bin Sun, Aliaksei V. Pukin, Alex van Belkum, Gerben M. Visser, Marie-France Karwaski, Barend van Lagen

Publikováno v: Carbohydrate Research : an international journal 343 (2008) 4
Carbohydrate Research : an international journal, 343(4), 636-650
Carbohydrate Research, 343(4), 636-650. Elsevier

Undee-10-enyl, undec-10-ynyl and 11-azidoundecyl glycoside analogues corresponding to the oligosaccharides of human gangliosides GM3, GM2 and GM1 were synthesized in high yields using glycosyltransferases from Campylobacter jejuni. Due to poor water

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b35ac2b0cd92eb7398da021e2af8de
https://doi.org/10.1016/j.carres.2008.01.007