Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Rainer, Merkl"'
Autor:
Robert Esch, Rainer Merkl
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background The order of genes in bacterial genomes is not random; for example, the products of genes belonging to an operon work together in the same pathway. The cotranslational assembly of protein complexes is deemed to conserve genomic ne
Externí odkaz:
https://doaj.org/article/0dac8a3415104413a96a6e19e43d8513
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008568 (2021)
Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been tailored to address various protei
Externí odkaz:
https://doaj.org/article/c670d4ef8cf84908876a0d0db0c5af43
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256691 (2021)
Rational protein design aims at the targeted modification of existing proteins. To reach this goal, software suites like Rosetta propose sequences to introduce the desired properties. Challenging design problems necessitate the representation of a pr
Externí odkaz:
https://doaj.org/article/6796b26ee9344f37b55d5c9ec3cd23aa
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background Large enzyme families may contain functionally diverse members that give rise to clusters in a sequence similarity network (SSN). In prokaryotes, the genome neighborhood of a gene-product is indicative of its function and thus, a
Externí odkaz:
https://doaj.org/article/4333c0531144484db589b8ca8c9fc58a
Autor:
Karolina Plössl, Kristina Straub, Verena Schmid, Franziska Strunz, Jens Wild, Rainer Merkl, Bernhard H F Weber, Ulrike Friedrich
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216320 (2019)
X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy, caused by mutations in the RS1 gene which encodes the secreted protein retinoschisin. In recent years, several molecules have been proposed to interact with retinoschisin, incl
Externí odkaz:
https://doaj.org/article/665b9225cca24c098d9a9b4856de6584
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 6, p e1005600 (2017)
Computational protein design (CPD) is a powerful technique to engineer existing proteins or to design novel ones that display desired properties. Rosetta is a software suite including algorithms for computational modeling and analysis of protein stru
Externí odkaz:
https://doaj.org/article/e3ee4b9dbca547e89bb740373759321d
Autor:
David Peterhoff, Stefanie Thalhauser, Patrick Neckermann, Clara Barbey, Kristina Straub, Julian Nazet, Rainer Merkl, Gernot Laengst, Miriam Breunig, Ralf Wagner
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
Selective targeting of germline B cells with specifically designed germline-targeting HIV-1 envelope immunogens (GT-Env) is considered a feasible vaccination strategy to elicit broadly neutralizing antibodies (bnAbs). BnAbs are extremely valuable bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708e9c9985fac6104ffe7c911187873
https://pubmed.ncbi.nlm.nih.gov/36272655
https://pubmed.ncbi.nlm.nih.gov/36272655
Autor:
Leonhard Heizinger, Andreas Fuchs, Stefan Dove, Regina Groebner-Ferreira, Helen Hoffmeister, Laura Strobl, Elizabeth A. Komives, Julian Nazet, Gernot Längst, Rainer Merkl
Publikováno v:
The FEBS Journal. 288:4000-4023
Chromatin remodelers use the energy of ATP hydrolysis to regulate chromatin dynamics. Their impact for development and disease requires strict enzymatic control. Here, we address the differential regulability of the ATPase domain of hSNF2H and hCHD3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d986b534418131a9ad7695620d566ab2
https://doi.org/10.1111/febs.15699
https://doi.org/10.1111/febs.15699
Autor:
Elisabeth Silberhorn, Uwe Schwartz, Patrick Löffler, Samuel Schmitz, Anne Symelka, Tania de Koning-Ward, Rainer Merkl, Gernot Längst
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006080 (2016)
The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nuc
Externí odkaz:
https://doaj.org/article/ff1bd278a9044d38bbed43616969f964
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005836 (2016)
Modern enzymes are highly optimized biocatalysts that process their substrates with extreme efficiency. Many enzymes catalyze more than one reaction; however, the persistence of such ambiguities, their consequences and evolutionary causes are largely
Externí odkaz:
https://doaj.org/article/cb8be713e80e4c698076db6b927a6e73