Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Rainer, König"'
Autor:
Reza Gheitasi, Daniela Röll, Mario M. Müller, Mohadeseh Naseri, Rainer König, Hortense Slevogt, Mathias W. Pletz, Oliwia Makarewicz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Staphylococcus aureus is a highly successful pathogen infecting various body parts and forming biofilms on natural and artificial surfaces resulting in difficult-to-treat and chronic infections. We investigated the secreted cytokines and proteomes of
Externí odkaz:
https://doaj.org/article/1caaf566d8ca4884aa0204e4d29d5610
Autor:
Ha‐Yeun Chung, Jonathan Wickel, Marcus Oswald, Justina Dargvainiene, Jan Rupp, Gernot Rohde, Martin Witzenrath, Frank Leypoldt, Rainer König, Mathias W. Pletz, Christian Geis, CAPNETZ Study Group
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 2, Pp 204-212 (2023)
Abstract Objective Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage and has been found to be elevated in several neurological diseases with neuronal destruction. New onset of confusion is a hallmark of severity in infectio
Externí odkaz:
https://doaj.org/article/659046cae1f045549ce9000d8f49a5a3
Autor:
Doris Höflmayer, Amélie Steinhoff, Claudia Hube‐Magg, Martina Kluth, Ronald Simon, Eike Burandt, Maria Christina Tsourlakis, Sarah Minner, Guido Sauter, Franziska Büscheck, Waldemar Wilczak, Stefan Steurer, Hartwig Huland, Markus Graefen, Alexander Haese, Hans Heinzer, Thorsten Schlomm, Frank Jacobsen, Andrea Hinsch, Alexandra M. Poos, Marcus Oswald, Karsten Rippe, Rainer König, Cornelia Schroeder
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 129-138 (2020)
The chromatin‐organizing factor CCCTC‐binding factor (CTCF) is involved in transcriptional regulation, DNA‐loop formation, and telomere maintenance. To evaluate the clinical impact of CTCF in prostate cancer, we analyzed CTCF expression by immu
Externí odkaz:
https://doaj.org/article/9e4b25c2846d448eb86d06c8d43dcc1a
Autor:
Alexandra M. Poos, Theresa Kordaß, Amol Kolte, Volker Ast, Marcus Oswald, Karsten Rippe, Rainer König
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood. Results We assemb
Externí odkaz:
https://doaj.org/article/4a5a6664d6554a45a6bd2bf964c52ee0
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks
Autor:
Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 5, Pp 1-20 (2019)
Abstract In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven hi
Externí odkaz:
https://doaj.org/article/d531e1d3965044bc9b7dc0b0a7049c9a
Autor:
Amol Kolte, Rainer König
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-14 (2019)
Abstract Background The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their peripheral immune cells.
Externí odkaz:
https://doaj.org/article/7af72c871ddb4e40a405cfa40bcd92de
Autor:
Rainer König, Amol Kolte, Olaf Ahlers, Marcus Oswald, Veiko Krauss, Daniela Roell, Oliver Sommerfeld, George Dimopoulos, Iraklis Tsangaris, Eleni Antoniadou, Neeraja Jaishankar, Holger Bogatsch, Markus Löffler, Markus Rödel, Marina Garcia-Moreno, Lorena Tuchscherr, Charles L. Sprung, Mervyn Singer, Frank Brunkhorst, Michael Oppert, Herwig Gerlach, Ralf A. Claus, Sina M. Coldewey, Josef Briegel, Evangelos J. Giamarellos-Bourboulis, Didier Keh, Michael Bauer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis of the datab
Externí odkaz:
https://doaj.org/article/594408ba31f8495d97a60fd7b13728f4
Autor:
Franziska Hörhold, David Eisel, Marcus Oswald, Amol Kolte, Daniela Röll, Wolfram Osen, Stefan B Eichmüller, Rainer König
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007657 (2020)
Upon exposure to different stimuli, resting macrophages undergo classical or alternative polarization into distinct phenotypes that can cause fatal dysfunction in a large range of diseases, such as systemic infection leading to sepsis or the generati
Externí odkaz:
https://doaj.org/article/4bba50c0a81b451b884c8ed48721d89e
Autor:
Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Jule Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W. Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degener
Externí odkaz:
https://doaj.org/article/463f3bfceed14b74b71020ee1edcf215
Autor:
João Pedro Saraiva, Marcus Oswald, Antje Biering, Daniela Röll, Cora Assmann, Tilman Klassert, Markus Blaess, Kristin Czakai, Ralf Claus, Jürgen Löffler, Hortense Slevogt, Rainer König
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background The human immune system is responsible for protecting the host from infection. However, in immunocompromised individuals the risk of infection increases substantially with possible drastic consequences. In extreme, systemic infect
Externí odkaz:
https://doaj.org/article/a93697315da642be969de5a5127e280f