Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rainer, Constien"'
Publikováno v:
genesis. 33:191-197
Summary: The versatility of the bacteriophage Cre/LoxP system is dependent on the availability of a spectrum of tissue-specific Cre transgenic mice to address a host of biological questions. In this paper, we report on the generation of an inducible
Autor:
Kevin Brady, Barbara Lenz, Niels Fisker, Michael J. Mihatsch, Bernd Altmann, Mudher Albassam, Georg Schmitt, Thomas Singer, Kamille Dumong Erichsen, Susanne Mohr, Thomas Weiser, Juergen Funk, Marco Berrera, Corinne Ploix, Franz Schuler, Robert Persson, Yann Tessier, Matthias Festag, Rainer Constien, Annamaria Braendli-Baiocco
Publikováno v:
Toxicological Sciences. :kfx025
Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safet
Autor:
Günter J. Hämmerling, Hermann Josef Gröne, Bernd Arnold, Peter P. Nawroth, Anne Forde, Rainer Constien, Birgit Liliensiek
Publikováno v:
genesis. 30:36-44
The use of the Cre/loxP system has greatly empowered the field of gene targeting. Here we describe the successful establishment of a novel knock-in EGFP reporter mouse line to monitor Cre-induced recombination in the vast majority of cell types. The
Autor:
Thomas J. Waldschmidt, Lutz Zeitlmann, Ann D. Friedman, Ping Lu, John D. Colgan, Umaima Al-Alem, Judit Knisz, Thomas F. Meyer, Johannes Grosse, Andreas Marquardt, Isaiah L. Hankel, Rainer Constien, Eric I. Elliott, Andreas Schroeder, Ming Yi Chiang, Paul B. Rothman, David K. Meyerholz
Publikováno v:
The Journal of Experimental Medicine
A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis. Transplantation experiments showed that homozygosity for Justy prevented hematopoietic progenitors from generating B c
Autor:
Jason Fuller, Valentina Busini, Naushad Hossain, Muthiah Manoharan, Andreas Zumbuehl, Timothy Racie, Rene Alvarez, Ivanka Toudjarska, Todd Borland, Kallanthottathil G. Rajeev, Jürgen Soutschek, Matthias John, Rainer Constien, Tracy Zimmermann, Dinah W.Y. Sah, Victor Koteliansky, K. Narayanannair Jayaprakash, Antonin de Fougerolles, Anna Borodovsky, Robert Langer, Akin Akinc, Elizaveta S. Leshchiner, June Qin, Denitza Raitcheva, Daniel G. Anderson, Michael S. Goldberg, Sergio Bacallado, David N. Nguyen, J. Robert Dorkin, Hans-Peter Vornlocher, Lubomir Nechev, Muthusamy Jayaraman
Publikováno v:
Nature Biotechnology, Vol. 26, No 5 (2008) pp. 561-569
Nature Biotechnology
Nature Biotechnology
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development. The diversity of current delivery materials remains limited, in part because of their slow, multi-step syntheses. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb1e02aa83371950ef1de530b3e00bc
http://hdl.handle.net/11311/513099
http://hdl.handle.net/11311/513099
Autor:
Rainer Constien, Michael S. Goldberg, Akin Akinc, Muthiah Manoharan, Daniel G. Anderson, Jürgen Soutschek, David Bumcrot, Hans-Peter Vornlocher, Martina Spranger, Philipp Hadwiger, Robert Langer, Jay D. Horton, Young Ah Moon, Matthias John, Victor Koteliansky, Markus Stoffel
Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates. Whether or not in vivo gene silencing by synthetic siRNA can disrupt the endogenous microRNA (miRNA) pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bb1cce31f52846a453be798506b108
https://europepmc.org/articles/PMC3019095/
https://europepmc.org/articles/PMC3019095/
Publikováno v:
Genesis (New York, N.Y. : 2000). 33(4)
The versatility of the bacteriophage Cre/LoxP system is dependent on the availability of a spectrum of tissue-specific Cre transgenic mice to address a host of biological questions. In this paper, we report on the generation of an inducible Tie2Cre t
Autor:
Ulrike Huffstadt, Matthias Schiemann, Helmut Fuchs, Rainer Constien, Geert C. Mudde, Michael Nehls, Martin Hrabé de Angelis, Andreas Popp, Leticia Quintanilla-Martinez, Sandra Kunder, Philipp Yu, Matilda Katan, Hermann Wagner, Andreas Marquardt, Klaus Pfeffer, Jürgen Laufs, Andreas Russ, Philipp Wabnitz, Andreas Schröder, Christian Schneider-Fresenius, Thomas Peters, Petra Hanke, Kei Yasuda, Neil P. Jones, Michelle Josephs, Johannes Grosse, Neil Dear, Tom D. Bunney, Thomas H. Meyer, Wolfgang Jagla, Carolin Schmittwolf
Publikováno v:
Immunity. (4):451-465
SummaryThe identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic heterogeneity present in human populations, an
Autor:
Olav Zilian, Ernst A. Wimmer, Gerd Vorbrüggen, Heike Taubert, Rainer Constien, Gordon Dowe, Herbert Jäckle, Markus Noll
Publikováno v:
Europe PubMed Central
Mechanisms of Development
Mechanisms of Development
We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the thir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6dd5a4c94cd8cf4abda9fdfec31ce
http://europepmc.org/abstract/med/9431811
http://europepmc.org/abstract/med/9431811