Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Raimund Kast"'
Autor:
Lorenz Bott-Flügel, Alexandra Bernshausen, Heike Schneider, Peter Luppa, Katja Zimmermann, Barbara Albrecht-Küpper, Raimund Kast, Karl-Ludwig Laugwitz, Heimo Ehmke, Andreas Knorr, Melchior Seyfarth
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18048 (2011)
The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would ha
Externí odkaz:
https://doaj.org/article/63555ebdf99643c99c8eb1a67af6172a
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3bcb4904153e431b637e901e8f4428
https://doi.org/10.1021/acs.jmedchem.0c00834
https://doi.org/10.1021/acs.jmedchem.0c00834
Autor:
Katja Zimmermann, Nicole Diedrichs, Walter Hübsch, Alexandros Vakalopoulos, Hans-Georg Lerchen, Thomas Kramer, Frank Süssmeier, Barbara Albrecht-Küpper, Raimund Kast, Ursula Krenz, Daniel Meibom, Peter G. Nell, Joachim Mittendorf
Publikováno v:
ChemMedChem. 12:728-737
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980d62cd9e6ae9380c0011ac41a9a756
https://doi.org/10.1002/cmdc.201700151
https://doi.org/10.1002/cmdc.201700151
Autor:
Michael, Härter, Bernd, Kalthof, Martina, Delbeck, Klemens, Lustig, Michael, Gerisch, Simone, Schulz, Raimund, Kast, Daniel, Meibom, Niels, Lindner
Publikováno v:
European journal of medicinal chemistry. 163
The A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71ef3f458da04ccb9b14f430596f21a3
https://pubmed.ncbi.nlm.nih.gov/30576906
https://pubmed.ncbi.nlm.nih.gov/30576906
Autor:
Daniel, Meibom, Barbara, Albrecht-Küpper, Nicole, Diedrichs, Walter, Hübsch, Raimund, Kast, Thomas, Krämer, Ursula, Krenz, Hans-Georg, Lerchen, Joachim, Mittendorf, Peter G, Nell, Frank, Süssmeier, Alexandros, Vakalopoulos, Katja, Zimmermann
Publikováno v:
ChemMedChem. 12(10)
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f63ae1aaa2ba4a447ae5d3791b0a6ba2
https://pubmed.ncbi.nlm.nih.gov/28488817
https://pubmed.ncbi.nlm.nih.gov/28488817
Autor:
Stefan Schäfer, Volker Laux, Katrin F. Nickel, Ralph T. Schermuly, Elisabeth Perzborn, Georges Von Degenfeld, Raimund Kast, Julia Strassburger, Martina Delbeck, Peter Ellinghaus
Publikováno v:
Cardiovascular Research. 92:159-168
Aims Anticoagulation with warfarin is recommended for the treatment of patients with pulmonary arterial hypertension (PAH). However, the therapeutic benefit of anticoagulation has not yet been demonstrated experimentally or clinically. Here, rivaroxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f63126a2d7d146b8ef500ec79f336a4
https://doi.org/10.1093/cvr/cvr168
https://doi.org/10.1093/cvr/cvr168
Autor:
Werner Seeger, Bhola K. Dahal, Johannes-Peter Stasch, Ralph T. Schermuly, Friedrich Grimminger, Norbert Weissmann, Akylbek Sydykov, Djuro Kosanovic, Hartmut Schirok, Lai Yj, P. K. Pamarthi, Raimund Kast, Hossein Ardeschir Ghofrani
Publikováno v:
European Respiratory Journal. 36:808-818
An accumulating body of evidence incriminates Rho kinase (ROCK) in the pathogenesis of pulmonary hypertension (PH). The therapeutic efficacy of azaindole-1, a novel highly selective and orally active ROCK inhibitor, has not yet been investigated in P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b5be0494166dd3e793a7937a8c058f
https://doi.org/10.1183/09031936.00140309
https://doi.org/10.1183/09031936.00140309
Autor:
Raimund Kast, H Tinel, Frank Wunder, Eva-Maria Becker, Joachim Hütter, A Geerts, Peter Kolkhof, M Härter, J Ergüden
Publikováno v:
British Journal of Pharmacology. 160:399-409
Background and purpose: Cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory and cardiovascular disorders. Their actions are mediated by CysLT1 and CysLT2 receptors. Here we report the discovery of 3-({[(1S,3S)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56ffa753badc4bb4da6372f62cbca5a
https://doi.org/10.1111/j.1476-5381.2010.00730.x
https://doi.org/10.1111/j.1476-5381.2010.00730.x
Autor:
K Zimmermann, Heimo Ehmke, Heiner Apeler, Santiago Figueroa-Pérez, Mario Lobell, Mark-Jean Gnoth, Klaus Münter, J Lenz, Joachim Dr. Hütter, K H Augstein, Johannes-Peter Stasch, Hartmut Schirok, Andreas Knorr, J K Franz, Joachim Mittendorf, Raimund Kast
Publikováno v:
British Journal of Pharmacology. 152:1070-1080
Background and purpose: Rho-kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally active ROCK inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f78bdb486662f3bfff261afb450ca8
https://doi.org/10.1038/sj.bjp.0707484
https://doi.org/10.1038/sj.bjp.0707484
Autor:
Frank Wunder, Johannes-Peter Stasch, Rupert Gerzer, Markus Hoenicka, Henning Schröder, Eva Maria Becker, Robyr Chantal, Raimund Kast
Publikováno v:
Nitric Oxide. 3:55-66
A stably transfected soluble guanylate cyclase (sGC, alpha1 and beta1 subunits of the rat lung enzyme)-overexpressing CHO cell line was generated for the characterization of different types of activators of the soluble guanylate cyclase. Polyclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44874855efb22ab54b31e0cee9dc51e6
https://doi.org/10.1006/niox.1999.0207
https://doi.org/10.1006/niox.1999.0207