Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Raimo K Tuominen"'
Autor:
Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)
Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro
Externí odkaz:
https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1
Autor:
Tiina Leppänen, Riku Korhonen, Mirka Laavola, Riina Nieminen, Raimo K Tuominen, Eeva Moilanen
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52741 (2013)
In inflammation, pro-inflammatory cytokines and bacterial products induce the production of high amounts of NO by inducible nitric oxide synthase (iNOS) in inflammatory and tissue cells. NO is an effector molecule in innate immunity, and it also has
Externí odkaz:
https://doaj.org/article/f247c629e725479eb30c01a55d9a1338
Autor:
Milla Summanen, Niko Granqvist, Raimo K Tuominen, Marjo Yliperttula, C Theo Verrips, Johannes Boonstra, Christophe Blanchetot, Elina Ekokoski
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35630 (2012)
Dysregulation of PKCε is involved in several serious diseases such as cancer, type II diabetes and Alzheimer's disease. Therefore, specific activators and inhibitors of PKCε hold promise as future therapeutics, in addition to being useful in resear
Externí odkaz:
https://doaj.org/article/9b60389161564e70bffc909754728330
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20053 (2011)
Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore considered attractive drug targets. Our group has
Externí odkaz:
https://doaj.org/article/e3685c5f959d4ba7b7a7922827e33017
Autor:
Saara Lautala, Riccardo Provenzani, Ilari Tarvainen, Katia Sirna, S. Tuuli Karhu, Evgeni Grazhdankin, Antti K. Lehtinen, Hanan Sa’d, Artturi Koivuniemi, Henri Xhaard, Raimo K. Tuominen, Virpi Talman, Alex Bunker, Jari Yli-Kauhaluoma
Publikováno v:
Journal of Medicinal Chemistry. 66:4588-4602
Autor:
Maria H. Jäntti, Virpi Talman, Kati Räsänen, Ilari Tarvainen, Hannu Koistinen, Raimo K. Tuominen
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 817-828 (2018)
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5‐year survival rate, development of resistance to standard androgen‐deprivation therapy is a significant clinical problem. Therefore, novel therapeutic s
Externí odkaz:
https://doaj.org/article/04c1350fde84491bb7286f40dc0a2c00
Autor:
Anna-Maija Penttinen, Ilmari Parkkinen, Merja H. Voutilainen, Maryna Koskela, Susanne Bäck, Anna Their, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Raimo K. Tuominen, Liina Nevalaita, Mart Saarma, Mikko Airavaara
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-regio
Externí odkaz:
https://doaj.org/article/0e3d168a5c6044e79f9fcb0e3793f8c3
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 380:54-62
Colorectal cancer is the third most commonly occurring cancer in men and the second in women. The global burden of colorectal cancer is projected to increase to over 2 million new cases with over 1 million deaths within the next 10 years, and there i
Autor:
Merja H. Voutilainen, Yulia Sidorova, Konsta Valkonen, Raimo K. Tuominen, Mart Saarma, Mati Karelson, Tanel Visnapuu, Juho-Matti Renko, Arun Kumar Mahato
Publikováno v:
Journal of Parkinson's Disease
Background: Parkinson’s disease (PD) is a progressive neurological disorder where loss of dopamine neurons in the substantia nigra and dopamine depletion in the striatum cause characteristic motor symptoms. Currently, no treatment is able to halt t
Autor:
Riccardo Provenzani, Alex Bunker, Raimo K. Tuominen, Virpi Talman, Jari Yli-Kauhaluoma, Saara Lautala, Waldemar Kulig, Artturi Koivuniemi, Tomasz Róg
Publikováno v:
Journal of Chemical Information and Modeling. 60:5624-5633
Increasing protein kinase C (PKC) activity is of potential therapeutic value. Its activation involves an interaction between the C1 domain and diacylglycerol (DAG) at intracellular membrane surfaces; DAG mimetics hold promise as new drugs. We previou