Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Raimar, Löbenberg"'
Autor:
Mayara Munhoz de Assis Ramos, Fernanda Yamamoto Ricardo-da-Silva, Luiza de Oliveira Macedo, Cristiano Jesus Correia, Luiz Felipe Pinho Moreira, Raimar Löbenberg, Ana Cristina Breithaupt-Faloppa, Nadia Bou-Chacra
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)
17β-estradiol (E2) is an endogenous steroid hormone pivotal for the development of female secondary sexual characteristics and the maintenance of the female reproductive system. Its roles extend beyond these physiological functions, as E2 is employe
Externí odkaz:
https://doaj.org/article/c9ea0bbb8f964e8dab595db255a4dc7d
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1843 (2024)
The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose regimen behavior.
Externí odkaz:
https://doaj.org/article/9dbdb6e7d048440ca2da0b520c7f6a82
Autor:
Malaz Yousef, Conor O’Croinin, Tyson S. Le, Chulhun Park, Jieyu Zuo, Nadia Bou Chacra, Neal M. Davies, Raimar Löbenberg
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 768 (2024)
Drug absorption via chylomicrons holds significant implications for both pharmacokinetics and pharmacodynamics. However, a mechanistic understanding of predicting in vivo intestinal lymphatic uptake remains largely unexplored. This study aimed to del
Externí odkaz:
https://doaj.org/article/cdb4c05a933c4a4ebeea737c110a4179
Autor:
Malaz Yousef, Tyson S Le, Jieyu Zuo, Chulhun Park, Nadia Bou Chacra, Neal M Davies, Raimar Löbenberg
Publikováno v:
Research in Pharmaceutical Sciences, Vol 18, Iss 1, Pp 1-15 (2023)
Background and purpose: Lysosomal-targeted drug delivery can open a new strategy for drug therapy. However, there is currently no universally accepted simulated or artificial lysosomal fluid utilized in the pharmaceutical industry or recognized by th
Externí odkaz:
https://doaj.org/article/d19eef5e80224d24867a522c2bb716e0
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2533 (2023)
This study aimed to investigate the enhancement of cannabinoid acid solubility and stability through the formation of a cannabinoid acid/cyclodextrin (CD) inclusion complex. Two cannabinoid acids, tetrahydro-cannabinolic acid (THCA) and cannabidiolic
Externí odkaz:
https://doaj.org/article/064ca61178884da0a5b14e8fab68ff67
Development of a Novel In Vitro Model to Study Lymphatic Uptake of Drugs via Artificial Chylomicrons
Autor:
Malaz Yousef, Chulhun Park, Mirla Henostroza, Nadia Bou Chacra, Neal M. Davies, Raimar Löbenberg
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2532 (2023)
The lymphatic system plays a crucial role in the absorption of lipophilic drugs, making it an important route for drug delivery. In this study, an in vitro model using Intralipid® was developed to investigate the lymphatic uptake of drugs. The model
Externí odkaz:
https://doaj.org/article/8681fa004b43498898b059fac63b25f5
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1941 (2023)
Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with demonstrated anti-inflammatory and antio
Externí odkaz:
https://doaj.org/article/a4fd24ee81c54b929fca6b38dc40db62
Autor:
Mehri Niazi, Parvin Zakeri-Milani, Mehdi Soleymani-Goloujeh, Ali Mohammadi, Muhammad Sarfraz, Raimar Löbenberg, saeedeh Najafi-Hajivar, Javid Shahbazi Mojarrad, Masoud Farshbaf, Hadi Valizadeh
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 24, Iss 3, Pp 383-390 (2021)
Objective(s): Doxorubicin (Dox) is one of the most well-known chemotherapeutics that are commonly applied for a wide range of cancer treatments. However, in most cases, efflux pumps like P-glycoprotein (P-gp), expel the taken drugs out of the cell an
Externí odkaz:
https://doaj.org/article/1b2baeebcf194145b2497083bacb79a7
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
The uniqueness of structure and physiology of the lymphatic system make it challenging to delineate all its contributions in the maintenance of our health. However, in the past two decades, the understanding of the importance of the function of this
Externí odkaz:
https://doaj.org/article/df1426da5a1c4021ad3ffc5c2a9ad926
Autor:
Richard H. Parrish, Lisa D. Ashworth, Raimar Löbenberg, Sandra Benavides, Jeffrey J. Cies, Robert B. MacArthur
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1032 (2022)
The purpose of this work was to evaluate the suitability of recent US Food and Drug Administration (US-FDA)-approved and marketed oral liquid, powder, or granule products for children in North America, to identify the next group of Active Pharmaceuti
Externí odkaz:
https://doaj.org/article/900e831085034434b695028b0eb10908