Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence

Autor: Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O’Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L.M. Björkegren, Zhidong Tu, Carmen Argmann

Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113371- (2023)

Summary: Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcripto

Externí odkaz: https://doaj.org/article/1c20f6d542d54b86acc9526737df22b2

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

Autor: Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucos

Externí odkaz: https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2

Global analysis of A-to-I RNA editing reveals association with common disease variants

Autor: Oscar Franzén, Raili Ermel, Katyayani Sukhavasi, Rajeev Jain, Anamika Jain, Christer Betsholtz, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Josefin Skogsberg, Ke Hao, Eric E. Schadt, Johan L.M. Björkegren

Publikováno v: PeerJ, Vol 6, p e4466 (2018)

RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6

Externí odkaz: https://doaj.org/article/400c7a24f8b34d1b987fdf4d12315de7

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

Autor: Nicholas J. Timpson, Jackie F. Price, Henning Tiemeier, Caroline Hayward, Stephan J. L. Bakker, Christian Gieger, Tom Michoel, Catriona L. K. Barnes, Ville Karhunen, Peter K. Joshi, Katyayani Sukhavasi, Anubha Mahajan, Carol A. Wang, Igor Rudan, Maik Pietzner, Andrew P. Morris, Craig E. Pennell, Andrew A Crawford, Marjo-Riitta Järvelin, Henry Völzke, Harry Campbell, Johan L.M. Björkegren, Pim van der Harst, David W. Clark, Massimo Mangino, Claes Ohlsson, Tim D. Spector, Jari Lahti, Elisabeth Altmaier, Johan G. Eriksson, Alexander Neumann, Raili Ermel, Maria Nethander, Arno Ruusalepp, James R M Wilson, George Davey Smith, Nele Friedrich, Sean Bankier, Brian R. Walker, Stela McLachlan

Publikováno v: Journal of human genetics
Journal of Human Genetics
Crawford, A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, van der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzne, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6SERPINA1 locusalters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expressionin peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics . https://doi.org/10.1038/s10038-020-00895-6
Journal of human genetics, 66(6), 625-636. Nature Publishing Group
Journal of Human Genetics, 66(6), 625-636. Nature Publishing Group
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Bjorkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M, Mclachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J, Rudan, I, Ruusalepp, A, Spector, T, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Smith, G D & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
J. Hum. Genet. 66, 625–636 (2021)
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J R M, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6

The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning plasma cortisol. Identifying a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ad4a1427b991f093b00510444007b
http://europepmc.org/articles/PMC8144017

Integrative Prioritization of Causal Genes for Coronary Artery Disease

Autor: Ke Hao, Raili Ermel, Katyayani Sukhavasi, Haoxiang Cheng, Lijiang Ma, Ling Li, Letizia Amadori, Simon Koplev, Oscar Franzén, Valentina d’Escamard, Nirupama Chandel, Kathryn Wolhuter, Nicole S. Bryce, Vamsidhar R.M. Venkata, Clint L. Miller, Arno Ruusalepp, Heribert Schunkert, Johan L.M. Björkegren, Jason C. Kovacic

Publikováno v: Circ Genom Precis Med

Background: Hundreds of candidate genes have been associated with coronary artery disease (CAD) through genome-wide association studies. However, a systematic way to understand the causal mechanism(s) of these genes, and a means to prioritize them fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa346728c1c64736287de11f8b0eec
https://doi.org/10.1161/circgen.121.003365