Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Raid B. Nisr"'
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 2310-2326 (2023)
Abstract Background Caveolins are the principal structural components of plasma membrane caveolae. Dominant pathogenic mutations in the muscle‐specific caveolin‐3 (Cav3) gene isoform, such as the limb girdle muscular dystrophy type 1C (LGMD‐1C)
Externí odkaz:
https://doaj.org/article/e035219594ad4502848bc7b29c515f6a
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101661- (2023)
Objective: Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we, demonstrate integration of metabolite and kinase-based immunometabolic control by AMP kinase. Methods:
Externí odkaz:
https://doaj.org/article/9997821d5e474d32b6b62c53f148b945
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 975-993 (2020)
Externí odkaz:
https://doaj.org/article/b32ae239c37e426eb541205bb4a80f1e
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 838-858 (2020)
Abstract Background Caveolin‐3 (Cav3) is the principal structural component of caveolae in skeletal muscle. Dominant pathogenic mutations in the Cav3 gene, such as the Limb Girdle Muscular Dystrophy‐1C (LGMD1C) P104L mutation, result in substanti
Externí odkaz:
https://doaj.org/article/333c56061fcd4028b3ac40c2fb14ab18
Autor:
Iain R. Phair, Raid B. Nisr, Andrew J.M. Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena
Publikováno v:
Molecular metabolism.
Previous mechanistic studies on immunometabolism have focused on metabolite-based paradigms of regulation, such as itaconate. Here, we combine whole cell quantitative proteomics with gene knockout of AMPKα1, to demonstrate integration of metabolite
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 838-858 (2020)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle
Background Caveolin‐3 (Cav3) is the principal structural component of caveolae in skeletal muscle. Dominant pathogenic mutations in the Cav3 gene, such as the Limb Girdle Muscular Dystrophy‐1C (LGMD1C) P104L mutation, result in substantial loss o
Publikováno v:
Cellular and Molecular Life Sciences
Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin resistance in skeletal muscle. Precisely how mitochondrial dysfunction i
Autor:
Charles Affourtit, Raid B. Nisr
Publikováno v:
Biochimica et Biophysica Acta
Insulin is essential for the regulation of fuel metabolism and triggers the uptake of glucose by skeletal muscle. The imported glucose is either stored or broken down, as insulin stimulates glycogenesis and ATP synthesis. The mechanism by which ATP p
Autor:
Charles Affourtit, Raid B. Nisr
Publikováno v:
Biochimica et biophysica acta. 1857(9)
Mitochondrial dysfunction has been associated with obesity-related muscle insulin resistance, but the causality of this association is controversial. The notion that mitochondrial oxidative capacity may be insufficient to deal appropriately with exce
Publikováno v:
FEMS Microbiology Letters. 328:93-99
Exposure to microorganisms is considered an environmental factor that can contribute to Type 1 diabetes. Insulin-binding proteins (IBPs) on microorganisms may induce production of antibodies that can react with the human insulin receptor (HIR) with p