Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Rahul V. Gopalkrishnan"'
Autor:
Devanand Sarkar, Zao-zhong Su, Irina V. Lebedeva, Moira Sauane, Rahul V. Gopalkrishnan, Paul Dent, Paul B. Fisher
Publikováno v:
BioTechniques, Vol 33, Iss 4S, Pp S30-S39 (2002)
One hallmark of neoplasia is abnormal differentiation. Induction of differentiation, by chemical or biological methods, provides a possible therapeutic intervention. “Differentiation therapy” is well documented in several model systems. These inc
Externí odkaz:
https://doaj.org/article/e145a02e01e54f3db3a567bf4afdd39d
Autor:
Irina V. Lebedeva, Rahul V. Gopalkrishnan, Paul B. Fisher, Zao Zhong Su, Devanand Sarkar, Moira Sauane, Kristoffer Valerie, Pankaj Gupta, Aaron Randolph
Publikováno v:
Cancer Research. 66:11869-11877
Biochemical and genetic mutation–based analyses confirm that the MDA-7/IL-24 protein can induce transformed cell–specific apoptosis through a mechanism involving endoplasmic reticulum (ER) stress–associated pathways. Covalent modifications by N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45716511087fadb56d89d69bfcc984ea
https://doi.org/10.1158/0008-5472.can-06-1887
https://doi.org/10.1158/0008-5472.can-06-1887
Autor:
Casey Cunningham, Devanand Sarkar, Irina V. Lebedeva, Zhao Zhong Su, Pankaj Gupta, Adly Yacoub, Paul B. Fisher, Paul Dent, John Nemunaitis, Rahul V. Gopalkrishnan, Moira Sauane
Publikováno v:
Molecular Therapy. 11(1):4-18
The mda-7/IL-24 cDNA was isolated almost a decade ago in a screen for genes differentially upregulated following growth arrest and terminal differentiation of a human melanoma cell line employed as an in vitro cell differentiation model. The underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944bbf0ffbef21c0928b27b823be95d4
Autor:
Manjula Kataram, Charles A. Leath, David T. Curiel, Hidde J. Haisma, Irina V. Lebedeva, Alexander Pereboev, Ronald D. Alvarez, Paul B. Fisher, Paul Dent, Delicia Carey, Pradeep Bhagavatula, Parameshwar J. Mahasreshti, Rahul V. Gopalkrishnan
Publikováno v:
Gynecologic Oncology, 94(2), 352-362. ACADEMIC PRESS INC ELSEVIER SCIENCE
Objective. Melanoma differentiation associated gene-7 [mda-7/interleukin (IL)-24] has been identified as a novel anti-cancer agent, which specifically induces apoptosis in cancer cells but not in normal epithelial, endothelial and fibroblast cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435de94ca030a10b8118ac0618fcf6c7
https://doi.org/10.1016/j.ygyno.2004.04.028
https://doi.org/10.1016/j.ygyno.2004.04.028
Publikováno v:
International Immunopharmacology. 4:635-647
Melanoma Differentiation Associated gene-7 (mda-7)/IL-24 has shown potent tumor cell apoptosis inducing capacity in multiple cancers, making it a strong candidate for use as a human cancer gene therapeutic. Several independent studies have currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4388e99c4bebf20c7512ac53983714
https://doi.org/10.1016/j.intimp.2004.01.015
https://doi.org/10.1016/j.intimp.2004.01.015
Autor:
Rahul V. Gopalkrishnan, David T. Curiel, Myrna R. Rosenfeld, Rajagopal Ramesh, Paul Dent, Paul B. Fisher, Elizabeth A. Grimm, Sunil Chada
Publikováno v:
Cancer Biology & Therapy. 2:22-36
An obstacle to effective gene-based cancer therapies is the limited number of cancer-specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction subtraction hybridization (DISH) approach with human melanoma cells, mela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3509c050c0847460dbaad1a6529d23e
https://doi.org/10.4161/cbt.458
https://doi.org/10.4161/cbt.458
Autor:
Zao-Zhong Su, Paul B. Fisher, Paul Dent, Carter Sigmon, Kristoffer Valerie, Rahul V. Gopalkrishnan, Irina V. Lebedeva, Adly Yacoub, Devanand Sarkar, Moira Sauane
Publikováno v:
Oncogene. 22:1164-1180
Malignant gliomas are extremely aggressive cancers currently lacking effective treatment modalities. Gene therapy represents a promising approach for this disease. A requisite component for improving gene-based therapies of brain cancer includes tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec4827cb202f5143fa18c21adfad520
https://doi.org/10.1038/sj.onc.1206062
https://doi.org/10.1038/sj.onc.1206062
Autor:
Irina V. Lebedeva, Devanand Sarkar, Moira Sauane, Rahul V. Gopalkrishnan, Zao-Zhong Su, Paul B. Fisher, Paul Dent
Publikováno v:
BioTechniques. 33:S30-S39
One hallmark of neoplasia is abnormal differentiation. Induction of differentiation, by chemical or biological methods, provides a possible therapeutic intervention. “Differentiation therapy” is well documented in several model systems. These inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2e54a1df3b3f59d084f35c510c8ebf
https://doi.org/10.2144/oct0204
https://doi.org/10.2144/oct0204
Autor:
Paul B. Fisher, Irina V. Lebedeva, Rahul V. Gopalkrishnan, Cy A. Stein, Paul Dent, John C. Reed, Neil I. Goldstein, Zao-Zhong Su
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10332-10337
Pancreatic cancer is an extremely aggressive neoplasm whose incidence equals its death rate. Despite intensive analysis, the genetic changes that mediate pancreatic cancer development and effective therapies for diminishing the morbidity associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76787b7c5ef029e707aec3dfaba90b5d
https://doi.org/10.1073/pnas.171315198
https://doi.org/10.1073/pnas.171315198
Autor:
Rahul V. Gopalkrishnan, Sandeep Tuli, Dong-Chul Kang, Terry Roberts, Keith A Christiansen, Paul B. Fisher
Publikováno v:
Oncogene. 19:4405-4416
The galectin family of proteins has been associated with several diverse cellular processes. More than 30 years since the discovery of the first member, precise biological functions for the family as a whole, or for individual members has proven elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7b55e4148bf4b4184f9d4654c9169
https://doi.org/10.1038/sj.onc.1203767
https://doi.org/10.1038/sj.onc.1203767