Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Rahul Thorat"'
Autor:
Bhasker Dharavath, Ashwin Butle, Akshita Chaudhary, Ankita Pal, Sanket Desai, Aniket Chowdhury, Rahul Thorat, Pawan Upadhyay, Sudhir Nair, Amit Dutt
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes. In this study, we report the identification and funct
Externí odkaz:
https://doaj.org/article/dfd4ef55c2d44f3f860d55cc13548b6e
Autor:
Abhiram Natu, Tripti Verma, Bharat Khade, Rahul Thorat, Poonam Gera, Sangita Dhara, Sanjay Gupta
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Cisplatin is an alkylating class of chemotherapeutic drugs used to treat cancer patients. However, cisplatin fails in long-term treatment, and drug resistance is the primary reason for tumor recurrence. Hence, understanding the mechanism of
Externí odkaz:
https://doaj.org/article/fe1f6723af554c7eb2b4dd6e8d53ee73
Autor:
Bhasker Dharavath, Ashwin Butle, Ankita Pal, Sanket Desai, Pawan Upadhyay, Aishwarya Rane, Risha Khandelwal, Sujith Manavalan, Rahul Thorat, Kavita Sonawane, Richa Vaish, Poonam Gera, Munita Bal, Anil K. D’Cruz, Sudhir Nair, Amit Dutt
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
MMP10, which is upregulated in 86% of primary tongue tumors with lymph node metastases, is negatively regulated by miR-944 and promotes nodal metastasis in an orthotopic tongue cancer mouse model through the AXL signaling pathway.
Externí odkaz:
https://doaj.org/article/8b679bba12d74b7cbe272b8156ba0657
Autor:
Asim Joshi, Ashwin Butle, Supriya Hait, Rohit Mishra, Vaishakhi Trivedi, Rahul Thorat, Anuradha Choughule, Vanita Noronha, Kumar Prabhash, Amit Dutt
Publikováno v:
Translational Oncology, Vol 22, Iss , Pp 101461- (2022)
Osimertinib, a third-generation EGFR tyrosine kinase inhibitor, shows significant benefit among patients with EGFR T790M mutation at disease progression. We analyzed the whole exome sequence of 48 samples obtained from 16 lung cancer patients with a
Externí odkaz:
https://doaj.org/article/2c2d1c8322a54a0a9f90f6c33fceddfd
Autor:
Crismita Dmello, Sharada Sawant, Hunain Alam, Prakash Gangadaran, Saie Mogre, Richa Tiwari, Zinia D'Souza, Manish Narkar, Rahul Thorat, Komal Patil, Devendra Chaukar, Shubhada Kane, Milind Vaidya
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172559 (2017)
Vimentin is an intermediate filament protein, predominantly expressed in cells of mesenchymal origin, although its aberrant expression is seen in many carcinomas during epithelial mesenchymal transition. In cancer, vimentin expression is associated w
Externí odkaz:
https://doaj.org/article/61557796f9d14a6193fc1be607881edc
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123979 (2015)
Plakophilin3 (PKP3) loss results in increased transformation in multiple cell lines in vitro and increased tumor formation in vivo. A microarray analysis performed in the PKP3 knockdown clones, identified an inflammation associated gene signature in
Externí odkaz:
https://doaj.org/article/24a30669590a4892b0b2e9b24d78ae24
Autor:
Lalit Sehgal, Rahul Thorat, Nileema Khapare, Amitabha Mukhopadhaya, Mugdha Sawant, Sorab N Dalal
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21975 (2011)
This report describes a technique for the generation of transgenic mice by in vivo manipulation of spermatogonial stem cells with a high rate of success. Spermatogonial stem cells (SSCs) in pre-pubescent animals were infected in vivo with recombinant
Externí odkaz:
https://doaj.org/article/42e4d417319b43b29b56fa3965429e41
Autor:
Anagha Acharekar, Ketaki Bachal, Pallavi Shirke, Rahul Thorat, Archisman Banerjee, Nilesh Gardi, Abhijit Majumder, Shilpee Dutt
Publikováno v:
Matrix Biology. 115:107-127
Recurrent glioblastoma is highly aggressive with currently no specific treatment regime. Therefore, to identify novel therapeutic targets for recurrent GBM, we used a cellular model developed in our lab from commercially available cell line U87MG and
Autor:
Hiren Dandia, Snehal Valvi, Rahul Thorat, Arvind Ingle, Abhijit De, Shubhada Chiplunkar, Prakriti Tayalia
Publikováno v:
National Research Scholars' Meet 2021 - Abstracts.
Autor:
Chella Krishna Vadivel, Subeer S. Manjumdar, Shweta Patel, Shruti Sinha, Rahul Thorat, Nirmalya Ganguli, Milind M. Vaidya, Sayli Jamghare, Hunain Alam, Richa Tiwari, Indrajit Sahu, Sanjay M. Bane
Publikováno v:
Cell Biology International. 45:1720-1732
Keratin 8/18, the predominant keratin pair of simple epithelia, is known to be aberrantly expressed in several squamous cell carcinomas (SCCs), where its expression is often correlated with increased invasion, neoplastic progression, and poor prognos