Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rahul Parakhia"'
Autor:
Isabelle Lee, Mihwa Na, Devin O'Brien, Rahul Parakhia, Nathalie Alépée, Walter Westerink, Irene Eurlings, Anne Marie Api
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 79
The U-SENS™ assay was developed to address the third key event of the skin sensitization adverse outcome pathway (AOP) and is described in OECD test guideline 442E, Annex II. A dataset of 68 fragrance ingredients comprised of 7 non-sensitizers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979f1ffe126875ecf854ab06ca4658e7
https://pubmed.ncbi.nlm.nih.gov/34902536
https://pubmed.ncbi.nlm.nih.gov/34902536
Autor:
Mihwa Na, Devin O'Brien, G. Frank Gerberick, Petra S. Kern, Maura Lavelle, Isabelle Lee, Rahul Parakhia, Cindy Ryan, Anne Marie Api
Publikováno v:
Regulatory Toxicology and Pharmacology. 130:105128
Potency determination of potential skin sensitizers in humans is essential for quantitative risk assessment and proper risk management. SENS-IS is an in vitro test based on a reconstructed human skin model, that was developed to predict the hazard an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a2102ee5b10027ca0897586200a027
https://doi.org/10.1016/j.yrtph.2022.105128
https://doi.org/10.1016/j.yrtph.2022.105128
Autor:
Ernst Ahlberg, Tatyana Y. Doktorova, Alexis Parenty, Thomas Exner, David Woolley, Angela White, Alessandro Brigo, Scott Miller, Jason Magby, Rahul Parakhia, David W. Roberts, Thibaud Weiler, Raymond R. Tice, David Faulkner, Eckart Krupp, Candice Y. Johnson, Amanda Giddings, Ana Theresa Paulino, Jessica Whritenour, Véronique Gervais, Barry Hardy, Ian M. Fearon, Louise Neilson, Alexandre Paulino, Sarah Campbell, Shayne C. Gad, Sol Bobst, Reinhard Stidl, Liat Lomnitski, Anna Vuorinen, Lawrence Milchak, Craig Zwickl, Harald Schlecker, Wolfgang Muster, David T. Szabo, Lisa Beilke, Mark T. D. Cronin, Daniel Urbisch, Glenn J. Myatt, Joel P. Bercu, Robert A. Jolly, Brian A. Wall, Markus Fehr, Romualdo Benigni, Lennart T. Anger, Ian Crooks, Patricia Parris, Kevin P. Cross, Joerg Wichard, David Bower, Diana Suarez-Rodrigez, Jedd Hillegass, Catrin Hasselgren, Susanne Glowienke, Jordi Mestres
Publikováno v:
Regul Toxicol Pharmacol
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc9080fa2ddd4532dad416d216a1d7b
http://hdl.handle.net/10230/45587
http://hdl.handle.net/10230/45587
Autor:
Rachael E. Tennant, Devin O'Brien, Thomas Steger-Hartmann, Jonathan D. Vessey, Steven J. Canipa, Ann De Smedt, Rachel Hemingway, Angela White, Martyn L. Chilton, Rahul Parakhia, Sylvain Etter, Jeffrey Plante, Jedd Hillegass, Janet Gould, Alun Myden, Paul Sterchele, Donna S. Macmillan, B. Smith
Publikováno v:
Journal of Applied Toxicology. 37:985-995
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2817357adcea70dfa0e1443634f86d91
https://doi.org/10.1002/jat.3448
https://doi.org/10.1002/jat.3448
Autor:
Donna S. Macmillan, B. Smith, Thomas Steger-Hartmann, Angela White, Rahul Parakhia, Milica Glogovac, Martyn L. Chilton, Paul Sterchele, Anna Vuorinen, Devin O'Brien, Susanne Glowienke, Sylvain Etter, Phillip Bellion, Jedd Hillegass, Ann De Smedt
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 95
A previously published fragmentation method for making reliable negative in silico predictions has been applied to the problem of predicting skin sensitisation in humans, making use of a dataset of over 2750 chemicals with publicly available skin sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d240d77c8aa2a9ba6e0960d9a5a9632
https://pubmed.ncbi.nlm.nih.gov/29580972
https://pubmed.ncbi.nlm.nih.gov/29580972
Autor:
Steven J, Canipa, Martyn L, Chilton, Rachel, Hemingway, Donna S, Macmillan, Alun, Myden, Jeffrey P, Plante, Rachael E, Tennant, Jonathan D, Vessey, Thomas, Steger-Hartmann, Janet, Gould, Jedd, Hillegass, Sylvain, Etter, Benjamin P C, Smith, Angela, White, Paul, Sterchele, Ann, De Smedt, Devin, O'Brien, Rahul, Parakhia
Publikováno v:
Journal of applied toxicology : JAT. 37(8)
Dermal contact with chemicals may lead to an inflammatory reaction known as allergic contact dermatitis. Consequently, it is important to assess new and existing chemicals for their skin sensitizing potential and to mitigate exposure accordingly. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb6b994eafdb2f3099447f035ba1c46c
https://pubmed.ncbi.nlm.nih.gov/28244128
https://pubmed.ncbi.nlm.nih.gov/28244128
Publikováno v:
The FASEB Journal. 29
Metformin, the most widely prescribed anti-diabetes drug, is correlated to a decreased cancer incidence in diabetes patients, and inhibits cancer cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d64cb34b3cec241746ef4eafd6a167
https://doi.org/10.1096/fasebj.29.1_supplement.725.15
https://doi.org/10.1096/fasebj.29.1_supplement.725.15
Autor:
Rahul Parakhia, Raymond S. Ochs
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb670c3eaf34931b727499c8d2b3208f
https://doi.org/10.1096/fasebj.27.1_supplement.1027.5
https://doi.org/10.1096/fasebj.27.1_supplement.1027.5