Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Rahul N, Kanadia"'
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
The emergence of introns was a significant evolutionary leap that is a major distinguishing feature between prokaryotic and eukaryotic genomes. While historically introns were regarded merely as the sequences that are removed to produce spliced trans
Externí odkaz:
https://doaj.org/article/2af6f10554ab4d02a7589f4399b30f10
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1)) result in tissue-specific symptoms. Given that the minor spliceoso
Externí odkaz:
https://doaj.org/article/8cfe79511d0c405190aed53d5ab0e737
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
An expanded cortex is a hallmark of human neurodevelopment and endows increased cognitive capabilities. Recent work has shown that the cell cycle-related gene NDE1 is essential for proper cortical development. Patients who have mutations in NDE1 exhi
Externí odkaz:
https://doaj.org/article/4a75126648e742e2bb53f5c8e0e7f66f
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Abstract Background Splicing is crucial for proper gene expression, and is predominately executed by the major spliceosome. Conversely, 722 introns in 699 human minor intron‐containing genes (MIGs) are spliced by the minor spliceosome. Splicing of
Externí odkaz:
https://doaj.org/article/8e7a33cecb8349c89655c81db218ddd7
Autor:
Linnaea E Ostroff, Emanuela Santini, Robert Sears, Zachary Deane, Rahul N Kanadia, Joseph E LeDoux, Tenzin Lhakhang, Aristotelis Tsirigos, Adriana Heguy, Eric Klann
Publikováno v:
eLife, Vol 8 (2019)
Local translation can support memory consolidation by supplying new proteins to synapses undergoing plasticity. Translation in adult forebrain dendrites is an established mechanism of synaptic plasticity and is regulated by learning, yet there is no
Externí odkaz:
https://doaj.org/article/0842f325d6e44b5a8e50779761297646
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Minor introns constitute
Externí odkaz:
https://doaj.org/article/15bfc65baf1a4a8cadc8954b33e64d16
Autor:
Kyle D. Drake, Saren M. Springer, Kevon O. Afriyie, Tomas D. Lopes, Kaitlin N. Girardini, Rahul N. Kanadia
SummaryDevelopmental insults causing limb progenitor cell cycle defects or death tend to produce micromelic limbs with maintained segmentation. This suggests that the developing limb is plastic yet has a bias towards proximo-distal patterning. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4ade20e92a9f978171915d9de20630
https://doi.org/10.1101/2022.11.10.516037
https://doi.org/10.1101/2022.11.10.516037
Autor:
Anouk M Olthof, Charles F Schwoerer, Audrey L Weber, Iswarya Arokiadhas, Karen Doggett, Stephen Mieruszynski, Avner Cnaani, Joan K Heath, Jakob Biran, Rahul N Kanadia
Despite the high conservation of minor introns across eukaryotic supergroups, specific lineages have completely lost minor intron splicing, which has raised questions about their evolution and purpose. Addressing these questions requires identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a5635cb2c56c21d041ee3aac88e55f
https://doi.org/10.1101/2022.10.12.511939
https://doi.org/10.1101/2022.10.12.511939
Autor:
Alisa K. White, Kyle D. Drake, Alexandra E. Porczak, Gabriela Tirado-Mansilla, Madisen F. Lee, Katery C. Hyatt, Chrissy Chow, Tava DeQuattro, Laura E. Mickelsen, Natale R. Sciolino, Alexander C. Jackson, Rahul N. Kanadia
While gene regulatory networks underlying hypothalamic development are being characterized, minor intron splicing remains unexplored. Here, we used Nkx2.1-Cre to ablate Rnu11, encoding the minor spliceosome-specific U11 snRNA, in the progenitors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6d6dc67241fe0b0de0282736d93f6d
https://doi.org/10.1101/2022.10.04.510883
https://doi.org/10.1101/2022.10.04.510883
Autor:
Stefan Wuchty, Alisa K. White, Anouk M. Olthof, Kyle Drake, Adam J. Hume, Judith Olejnik, Elke Mühlberger, Vanessa Aguiar-Pulido, Rahul N. Kanadia
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed the world’s unpreparedness to deal with the emergence of novel pathogenic viruses, pointing to the urgent need to identify targets for broad-spectrum a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b8a121600a33f546ad856ca79aebf8
https://doi.org/10.1101/2022.09.30.510319
https://doi.org/10.1101/2022.09.30.510319