Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Rahul M, Kohli"'
Autor:
Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have unders
Externí odkaz:
https://doaj.org/article/15da1f095f5e460fb87e5885ecd73cc9
Autor:
Hugo C. Medina-Munoz, Eric Kofman, Pratibha Jagannatha, Evan A. Boyle, Tao Yu, Krysten L. Jones, Jasmine R. Mueller, Grace D. Lykins, Andrew T. Doudna, Samuel S. Park, Steven M. Blue, Brodie L. Ranzau, Rahul M. Kohli, Alexis C. Komor, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editing) and STAMP (surveying targets by APOBEC
Externí odkaz:
https://doaj.org/article/8d2fba859be64189bf8bdb600ad90c27
Autor:
Iris K. Lee, Daniel A. Jacome, Joshua K. Cho, Vincent Tu, Anthony J. Young, Tiffany Dominguez, Justin D. Northrup, Jean M. Etersque, Hsiaoju S. Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J. Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M. Kohli, Robert H. Mach, David A. Mankoff, Robert K. Doot, Mark A. Sellmyer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2023)
BACKGROUND Several molecular imaging strategies can identify bacterial infections in humans. PET affords the potential for sensitive infection detection deep within the body. Among PET-based approaches, antibiotic-based radiotracers, which often targ
Externí odkaz:
https://doaj.org/article/30dd4ba430cb4828857bbc391f587035
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101314- (2022)
Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome. The canonical epigenetic mark is 5-methylcytosine (5mC), but oxidized versions of 5mC,
Externí odkaz:
https://doaj.org/article/12c6b9eaa171460caf362a365d6fa3e4
Autor:
Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt, Zhendong Cao, Elizabeth S. Freilich, Qingzhou Chen, Jun Qi, Yemin Lan, Rahul M. Kohli, Junwei Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.
Externí odkaz:
https://doaj.org/article/200dde47acd44d708c32a6bcf129cbd0
Autor:
Juan C. Serrano, Dora von Trentini, Kiara N. Berríos, Aleksia Barka, Ivan J. Dmochowski, Rahul M. Kohli
Publikováno v:
ACS Chemical Biology. 17:3379-3388
Nucleic acid structure plays a critical role in governing the selectivity of DNA- and RNA-modifying enzymes. In the case of the APOBEC3 family of cytidine deaminases, these enzymes catalyze the conversion of cytosine (C) to uracil (U) in single-stran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6923fb73a9b6842a580a31b0eea4a7
https://doi.org/10.1021/acschembio.2c00796
https://doi.org/10.1021/acschembio.2c00796
Autor:
Rahul M Kohli, Stuart N Isaacs
Publikováno v:
The Journal of Infectious Diseases. 227:828-830
The recent mpox (monkeypox) outbreak has prompted genomic studies to track global spread of the disease. These studies have also revealed unexpected patterns of mutations that implicate the action of the immune defense APOBEC3 family of enzymes, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b74e8d71c2c2e52083e563d2817628df
https://doi.org/10.1093/infdis/jiac471
https://doi.org/10.1093/infdis/jiac471
Autor:
Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Matthew J. Culyba, Zachary M. Hostetler, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response
Externí odkaz:
https://doaj.org/article/fc69e9d5be4840acbcfd56e5aaba5e04
Autor:
Zhen Zhang, Amy E. Baxter, Diqiu Ren, Kunhua Qin, Zeyu Chen, Sierra M. Collins, Hua Huang, Chad A. Komar, Peter F. Bailer, Jared B. Parker, Gerd A. Blobel, Rahul M. Kohli, E. John Wherry, Shelley L. Berger, Junwei Shi
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b217dcc415fa50f2454981cc3a9e7840
https://doi.org/10.1038/s41587-023-01756-1
https://doi.org/10.1038/s41587-023-01756-1
Autor:
Michael B. Cory, Chloe M. Jones, Kyle D. Shaffer, Yarra Venkatesh, Sam Giannakoulias, Ryann M. Perez, Marshall G. Lougee, Eshe Hummingbird, Vinayak V. Pagar, Christina M. Hurley, Allen Li, Robert H. Mach, Rahul M. Kohli, E. James Petersson
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65ca50bd4abc5c3b2113787635717179
https://doi.org/10.1002/pro.4633
https://doi.org/10.1002/pro.4633