Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rahul K. Keswani"'
Autor:
Gus R. Rosania, Phillip Rzeczycki, Brian Gregorka, Rahul K. Keswani, Vernon LaLone, Tehetina Woldemichael, Joel A. Swanson, Kathleen A. Stringer, Mikhail D. Murashov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Weakly basic, poorly soluble chemical agents could be exploited as building blocks for constructing sophisticated molecular devices inside the cells of living organisms. Here, using experimental and computational approaches, we probed the relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85097548aed88afc8cc600d57ef091ea
http://link.springer.com/article/10.1038/s41598-018-21271-7
http://link.springer.com/article/10.1038/s41598-018-21271-7
Autor:
Gi Sang Yoon, Cora McHugh, Yihan Sun, Gus R. Rosania, Victor Vitvitsky, Rahul K. Keswani, Sudha Sud, Larisa Yeomans, Kathleen A. Stringer, Julie Trexel, Ruma Banerjee
Publikováno v:
Journal of Pharmaceutical Sciences. 106:1162-1174
Prolonged (8 weeks) oral administration of clofazimine results in a profound pharmacodynamic response—bioaccumulation in macrophages (including Kupffer cells) as intracellular crystal-like drug inclusions (CLDIs) with an associated increase in inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4a173a4fd6ebfbf5a72e0a8772099f
https://doi.org/10.1016/j.xphs.2016.12.009
https://doi.org/10.1016/j.xphs.2016.12.009
Autor:
Zhenzhen Fan, Mikhail D. Murashov, Xiaowei Hong, Phillip Rzeczycki, Cheri X. Deng, Gus R. Rosania, Rahul K. Keswani
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c92c32f76e3c98c176bcd9e59be1584
https://doi.org/10.1038/s41598-019-42180-3
https://doi.org/10.1038/s41598-019-42180-3
Publikováno v:
Pharmaceutical Research. 33:2999-3011
siRNA may be delivered as electrostatic complexes with cationic lipids (lipoplexes) or polycations (polyplexes). The purpose of this project was to determine the effect of cellular internalization mechanism(s) on siRNA-mediated gene silencing efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e652e63829350b7e9996e07b8c2527b
https://doi.org/10.1007/s11095-016-2022-1
https://doi.org/10.1007/s11095-016-2022-1
Autor:
Theodore J. Standiford, Kathleen A. Stringer, Phillip Rzeczycki, Tony A. Koehn, Sudha Sud, Mikhail D. Murashov, Gi Sang Yoon, Rahul K. Keswani, Gus R. Rosania
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:3470-3479
Clofazimine (CFZ) is a poorly soluble antibiotic and anti-inflammatory drug indicated for the treatment of leprosy. In spite of its therapeutic value, CFZ therapy is accompanied by the formation of drug biocrystals that accumulate within resident tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266fb06670e75b298ab962498f54cc41
https://doi.org/10.1128/aac.00265-16
https://doi.org/10.1128/aac.00265-16
Autor:
Tehetina Woldemichael, Phillip Rzeczycki, Andrew R. Willmer, Mikhail D. Murashov, Rahul K. Keswani, Naír Rodríguez-Hornedo, Kathleen A. Stringer, Gus R. Rosania, Jason Baik, Gi Sang Yoon
Publikováno v:
Pharmaceutical Research. 36
PURPOSE: Clofazimine (CFZ) is an FDA-approved, poorly soluble small molecule drug that precipitates as crystal-like drug inclusions (CLDIs) which accumulate in acidic cytoplasmic organelles of macrophages. In this study, we considered CLDIs as an exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa7de0a70ed16ed3338c2d70fd9268f
https://doi.org/10.1007/s11095-018-2539-6
https://doi.org/10.1007/s11095-018-2539-6
Autor:
Rahul K. Keswani, Gi Sang Yoon, Mikhail D. Murashov, Ingrid L. Bergin, Phillip Rzeczycki, Gus R. Rosania, Kathleen A. Stringer, Jason Baik, Sudha Sud
Publikováno v:
Pharmaceutical research. 36(1)
PURPOSE: Drug-induced liver injuries (DILI) comprise a significant proportion of adverse drug reactions leading to hospitalizations and death. One frequent DILI is granulomatous inflammation from exposure to harmful metabolites that activate inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122aa933dad4e931c072e9c0f66dc9f0
https://pubmed.ncbi.nlm.nih.gov/30406478
https://pubmed.ncbi.nlm.nih.gov/30406478
Publikováno v:
Cytometry Part A. 87:855-867
Clofazimine (CFZ) is an optically active, red-colored chemotherapeutic agent that is FDA approved for the treatment of leprosy and is on the World Health Organization's list of essential medications. Interestingly, CFZ massively accumulates in macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d3bd4f0950bc92dad15a39827f25e5
https://doi.org/10.1002/cyto.a.22706
https://doi.org/10.1002/cyto.a.22706
Publikováno v:
Journal of Controlled Release. 207:120-130
Viral and non-viral gene delivery vectors are in development for human gene therapy, but both exhibit disadvantages such as inadequate efficiency, lack of cell-specific targeting or safety concerns. We have recently reported the design of hybrid deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba269466474a1df5945dd5fcd35db1b1
https://doi.org/10.1016/j.jconrel.2015.04.015
https://doi.org/10.1016/j.jconrel.2015.04.015
Autor:
Vernon LaLone, Mikhail D. Murashov, Phillip Rzeczycki, Rahul K. Keswani, Gi Sang Yoon, Scott D. Larsen, Walajapet Rajeswaran, Gus R. Rosania, Sudha Sud, Kathleen A. Stringer
Clofazimine is a weakly basic, Food and Drug Administration-approved antibiotic recommended by the World Health Organization to treat leprosy and multi-drug-resistant tuberculosis. Upon prolonged treatment, clofazimine extensively bioaccumulates and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579dc02bfebeda81e0dbcae4e24571b
https://europepmc.org/articles/PMC5828885/
https://europepmc.org/articles/PMC5828885/
