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Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes

Autor: Hilary Nepon, Rahul Jayas, Brooke Lieberman, Graham G. Maddaford, Pegah Afshar, Rimpy Dhingra, Lorrie A. Kirshenbaum, Johnathan Gerstein, Victoria Margulets, Matthew Guberman, Abhinav Dhingra

Publikováno v: Free radical biologymedicine. 112

The Bcl-2 protein Bnip3 is crucial for provoking oxidative injury to mitochondria following anthracycline treatment or ischemia-reperfusion injury. Herein, we investigate the effects of the polyphenolic compound ellagic acid (EA) on Bnip3 mediated mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659af30035244a11e19875d0beb795c7
https://pubmed.ncbi.nlm.nih.gov/28838842

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Abstract 25: Polyphenolic - Ellagic Acid Suppresses Mitophagy- Induced Necrotic Cell Death During Doxorubicin Cardiotoxicity

Autor: Abhinav Dhingra, Rimpy Dhingra, Rahul Jayas, Lorrie A. Kirshenbaum

Publikováno v: Circulation Research. 117

Reactive oxygen species (ROS) play a major role in cardiac dysfunction during myocardial ischemia. ROS production has been linked to oxidative stress injury and mitochondrial perturbations including permeability transition pore opening (mPTP), loss o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ba51fa40b52b0ed8a5fbef4ca519936
https://doi.org/10.1161/res.117.suppl_1.25

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