Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Rahul C Deo"'
Autor:
James Truslow, Angela Spillane, Huiming Lin, Katherine Cyr, Adeeti Ullal, Edith Arnold, Ron Huang, Laura Rhodes, Jennifer Block, Jamie Stark, James Kretlow, Alexis L. Beatty, Andreas Werdich, Deepali Bankar, Matt Bianchi, Ian Shapiro, Jaime Villalpando, Sharon Ravindran, Irida Mance, Adam Phillips, John Earl, Rahul C. Deo, Sumbul A. Desai, Calum A. MacRae
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Physical activity or structured exercise is beneficial in a wide range of circumstances. Nevertheless, individual-level data on differential responses to various types of activity are not yet sufficient in scale, duration or level of annotat
Externí odkaz:
https://doaj.org/article/c192414062ae4c2c91f292e042f17665
Autor:
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo
Publikováno v:
eLife, Vol 4 (2015)
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, sugges
Externí odkaz:
https://doaj.org/article/64ef752df04c4b96ab2dff639a70afb6
Autor:
Ryuichiro Yagi, Shinichi Goto, Yukihiro Himeno, Yoshinori Katsumata, Masahiro Hashimoto, Calum A. MacRae, Rahul C. Deo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of the patients undergo surveillance echocardiograms. An AI model detecting reduced le
Externí odkaz:
https://doaj.org/article/3dd4166c5df2494caeb4df921f5a2f48
Autor:
Rahul C Deo, James G Wilson, Chao Xing, Kim Lawson, W H Linda Kao, David Reich, Arti Tandon, Ermeg Akylbekova, Nick Patterson, Thomas H Mosley, Eric Boerwinkle, Herman A Taylor
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14581 (2011)
Lipoprotein(a) (Lp(a)) is an important causal cardiovascular risk factor, with serum Lp(a) levels predicting atherosclerotic heart disease and genetic determinants of Lp(a) levels showing association with myocardial infarction. Lp(a) levels vary wide
Externí odkaz:
https://doaj.org/article/21d824337bd741dfbc4ca042be1dd301
Autor:
Frank H Lau, Rahul C Deo, Gregory Mowrer, Joshua Caplin, Tim Ahfeldt, Adam Kaplan, Leon Ptaszek, Jennifer D Walker, Bruce R Rosengard, Chad A Cowan
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26092 (2011)
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United States. Recent studies suggest that pericardial adipose tissue (PCAT) secretes inflammatory factors that contribute to the development of CVD. To better c
Externí odkaz:
https://doaj.org/article/d08babaecd79469caa9afcd3fcef7d6a
Autor:
Rahul C Deo, Luke Hunter, Gregory D Lewis, Guillaume Pare, Ramachandran S Vasan, Daniel Chasman, Thomas J Wang, Robert E Gerszten, Frederick P Roth
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 2, p e1000692 (2010)
Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the underlying biologic state of indiv
Externí odkaz:
https://doaj.org/article/2c252d2893e74961a368e9755e4cb1cf
Autor:
Rahul C Deo, David Reich, Arti Tandon, Ermeg Akylbekova, Nick Patterson, Alicja Waliszewska, Sekar Kathiresan, Daniel Sarpong, Herman A Taylor, James G Wilson
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000342 (2009)
Genome-wide association analysis in populations of European descent has recently found more than a hundred genetic variants affecting risk for common disease. An open question, however, is how relevant the variants discovered in Europeans are to othe
Externí odkaz:
https://doaj.org/article/4005d2655efa4ddd9c05e36312295a92
Autor:
Rahul C Deo, Nick Patterson, Arti Tandon, Gavin J McDonald, Christopher A Haiman, Kristin Ardlie, Brian E Henderson, Sean O Henderson, David Reich
Publikováno v:
PLoS Genetics, Vol 3, Iss 11, p e196 (2007)
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a large-scale admixture scan for ge
Externí odkaz:
https://doaj.org/article/f47788c5b4df4f7292741f2ed58ace6a
Publikováno v:
Journal of the American Society of Echocardiography. 35:1238-1246
View classification is a key step toward building a fully automated system for interpretation of echocardiograms. However, compared with adult echocardiograms, creating a view classification model for pediatric echocardiograms poses additional challe
Publikováno v:
European Heart Journal - Digital Health. 3:654-657
AimLeft ventricular systolic dysfunction (LVSD) carries an increased risk for overt heart failure and mortality, yet treatable to mitigate disease progression. An artificial intelligence (AI)-enabled 12-lead electrocardiogram (ECG) model demonstrated