miR-1468-3p promotes aging–related cardiac fibrosis

Autor: Lin, R. (Ruizhu), Rahtu-Korpela, L. (Lea), Magga, J. (Johanna), Ulvila, J. (Johanna), Swan, J. (Julia), Kemppi, A. (Anna), Pakanen, L. (Lasse), Porvari, K. (Katja), Huikuri, H. (Heikki), Junttila, J. (Juhani), Kerkelä, R. (Risto)

Non-coding microRNAs (miRNAs) are powerful regulators of gene expression and critically involved in cardiovascular pathophysiology. The aim of the current study was to identify miRNAs regulating cardiac fibrosis. Cardiac samples of age-matched contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::d07f594852869d100c67156d8fc078a7
http://urn.fi/urn:nbn:fi-fe2020070646949

MiR-185-5p regulates the development of myocardial fibrosis.

Autor: Lin R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Rahtu-Korpela L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Szabo Z; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland; Division of Cardiology, Research Unit of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland., Kemppi A; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Skarp S; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Kiviniemi AM; Division of Cardiology, Research Unit of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland., Lepojärvi ES; Division of Cardiology, Research Unit of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland., Halmetoja E; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Kilpiö T; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland., Porvari K; Department of Forensic Medicine, Research Unit of Internal Medicine, University of Oulu, Oulu, Finland., Pakanen L; Department of Forensic Medicine, Research Unit of Internal Medicine, University of Oulu, Oulu, Finland; Forensic Medicine Unit, Finnish Institute for Health and Welfare, Oulu, Finland., Tolva J; Transplantation laboratory, Department of Pathology, University of Helsinki, Finland., Paakkanen R; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Finland., Segersvärd H; Unit of Cardiovascular Research, Minerva Institute for Medical Research, Helsinki, Finland., Tikkanen I; Unit of Cardiovascular Research, Minerva Institute for Medical Research, Helsinki, Finland; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Laine M; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Finland., Sinisalo J; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Finland., Lakkisto P; Unit of Cardiovascular Research, Minerva Institute for Medical Research, Helsinki, Finland; Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital, Finland., Huikuri H; Division of Cardiology, Research Unit of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Magga J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland., Junttila J; Division of Cardiology, Research Unit of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland., Kerkelä R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland. Electronic address: Risto.Kerkela@oulu.fi.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2022 Apr; Vol. 165, pp. 130-140. Date of Electronic Publication: 2021 Dec 29.

Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.

Autor: García-Martín, Adela^1,2,3 (AUTHOR) bc2gamam@uco.es, Prados, María E.^1,2,3 (AUTHOR), Lastres-Cubillo, Isabel^1,3 (AUTHOR), Ponce-Diaz, Francisco J.^1,2,3 (AUTHOR), Cerero, Laura^1,2,3 (AUTHOR), Garrido-Rodríguez, Martin⁴ (AUTHOR), Navarrete, Carmen^1,3 (AUTHOR), Pineda, Rafael^1,2,3 (AUTHOR), Rodríguez, Ana B.^1,2,3 (AUTHOR), Muñoz, Ignacio^1,3 (AUTHOR), Moya, Javier^1,3 (AUTHOR), Medeot, Antonella^1,3 (AUTHOR), Moreno, José A.^1,3 (AUTHOR), Chacón, Antonio^1,3 (AUTHOR), García-Revillo, José^1,3 (AUTHOR), Muñoz, Eduardo^1,2,3 (AUTHOR) fi1muble@uco.es

Publikováno v: Journal of Translational Medicine. 11/6/2024, Vol. 22 Issue 1, p1-24. 24p.

Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function.

Autor: Szabó Z; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland., Vainio L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland., Lin R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Swan J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland., Hulmi JJ; Faculty of Sport and Health Sciences, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Rahtu-Korpela L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland., Serpi R; Biocenter Oulu, University of Oulu, Oulu, Finland.; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Laitinen M; Department of Medicine, University of Helsinki, Helsinki, Finland.; Department of Medicine, Helsinki University Hospital, Helsinki, Finland., Pasternack A; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Ritvos O; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kerkelä R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Magga J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Aug; Vol. 34 (8), pp. 9911-9924. Date of Electronic Publication: 2020 May 19.

Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Autor: Magga J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Biocenter Oulu, University of Oulu, 90220 Oulu, Finland. Electronic address: johanna.magga@oulu.fi., Vainio L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Kilpiö T; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Hulmi JJ; Neuromuscular Research Center, Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, 40014 Jyväskylä, Finland; Department of Physiology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Taponen S; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Lin R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland., Räsänen M; Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Szabó Z; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Gao E; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA., Rahtu-Korpela L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Alakoski T; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Ulvila J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland., Laitinen M; Department of Medicine, University of Helsinki, 00029 Helsinki, Finland; Department of Medicine, Helsinki University Hospital, 00029 Helsinki, Finland., Pasternack A; Department of Physiology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Koch WJ; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA., Alitalo K; Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Kivelä R; Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Ritvos O; Department of Physiology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland., Kerkelä R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Mar 06; Vol. 27 (3), pp. 600-610. Date of Electronic Publication: 2019 Jan 24.